Synaptic Systems - Tomosyn2

Cat. No.: 183 203

Amount: 50 µg

Price: $380.00

Cat. No. 183 203	50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 1000 (AP staining) gallery IP: not tested yet ICC: not tested yet IHC: not tested yet IHC-P: not tested yet
Immunogen	Recombinant protein corresponding to AA 828 to 983 from mouse Tomosyn2 (UniProt Id: Q5DQR4)
Reactivity	Reacts with: rat, mouse (Q5DQR4). Other species not tested yet.
Specificity	K.O. validated PubMed: 24744148
Data sheet	183_203.pdf

Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates.
Geerts CJ, Plomp JJ, Koopmans B, Loos M, van der Pijl EM, van der Valk MA, Verhage M, Groffen AJ
Brain structure & function (2015) 2204: 1971-82. 183 203 WB; KO verified; tested species: mouse

Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons.
Subkhangulova A, Gonzalez-Lozano MA, Groffen AJA, van Weering JRT, Smit AB, Toonen RF, Verhage M
eLife (2023) 12: . 183 203 WB; KO verified; tested species: mouse

The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology.
Saldate JJ, Shiau J, Cazares VA, Stuenkel EL
The Journal of biological chemistry (2018) 2937: 2232-2246. 183 203 WB; tested species: rat

Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains.
Geerts CJ, Mancini R, Chen N, Koopmans FTW, Li KW, Smit AB, van Weering JRT, Verhage M, Groffen AJA
PloS one (2017) 127: e0180912. 183 203 WB, ICC; tested species: mouse

Cat. No.: 183 203

Amount: 50 µg

Price: $380.00

Background

Protocols

Tomosyn2 antibody - 183 203 K.O.