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Home > Products > 183 103

Tomosyn1 antibody - 183 103 K.O.

Tomosyns are syntaxin 1 binding partners
Rabbit polyclonal purified antibody
Cat. No.: 183 103
Amount: 50 µg
Price: $380.00
Cat. No. 183 103 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 gallery  
Immunogen Recombinant protein corresponding to AA 561 to 774 from mouse Tomosyn1 (UniProt Id: Q8K400)
Reactivity Reacts with: rat (Q9WU70), mouse (Q8K400).
Other species not tested yet.
Specificity K.O. validated PubMed: 24744148
Data sheet 183_103.pdf

References for Tomosyn1 - 183 103

Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates.
Geerts CJ, Plomp JJ, Koopmans B, Loos M, van der Pijl EM, van der Valk MA, Verhage M, Groffen AJ
Brain structure & function (2015) 2204: 1971-82. 183 103 WB; KO verified
Genetic ablation of synaptotagmin-9 alters tomosyn-1 function to increase insulin secretion from pancreatic β-cells improving glucose clearance.
Rahman MM, Pathak A, Schueler KL, Alsharif H, Michl A, Alexander J, Kim JA, Bhatnagar S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2023) 378: e23075. 183 103 WB, ICC; tested species: mouse
Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons.
Subkhangulova A, Gonzalez-Lozano MA, Groffen AJA, van Weering JRT, Smit AB, Toonen RF, Verhage M
eLife (2023) 12: . 183 103 WB, ICC; KO verified; tested species: mouse
Tomosyn regulates the small RhoA GTPase to control the dendritic stability of neurons and the surface expression of AMPA receptors.
Shen W, Kilander MBC, Bridi MS, Frei JA, Niescier RF, Huang S, Lin YC
Journal of neuroscience research (2020) : . 183 103 WB, IP, ICC; tested species: mouse
Actions of Rab27B-GTPase on mammalian central excitatory synaptic transmission.
Arias-Hervert ER, Xu N, Njus M, Murphy GG, Hou Y, Williams JA, Lentz SI, Ernst SA, Stuenkel EL
Physiological reports (2020) 89: e14428. 183 103 WB; tested species: mouse
The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology.
Saldate JJ, Shiau J, Cazares VA, Stuenkel EL
The Journal of biological chemistry (2018) 2937: 2232-2246. 183 103 WB, IP, ICC; KD verified; tested species: rat
Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn.
Cazares VA, Njus MM, Manly A, Saldate JJ, Subramani A, Ben-Simon Y, Sutton MA, Ashery U, Stuenkel EL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3644: 11208-11222. 183 103 WB, ICC; KD verified; tested species: rat
Cat. No.: 183 103
Amount: 50 µg
Price: $380.00
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