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GluA2 antibody - 182 105

GluAs are ionotropic glutamate receptors involved in rapid excitatory neurotransmission
Guinea pig polyclonal purified antibody
Cat. No.: 182 105
Amount: 50 µg
Price: $465.00
Cat. No. 182 105 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 gallery  
Immunogen Recombinant protein corresponding to AA 836 to 883 from rat GluA2 (UniProt Id: P19491)
Reactivity Reacts with: rat (P19491), mouse.
Other species not tested yet.
Specificity Some cross reactivity to GluA 3.
Matching control protein/peptide 182-1P
Data sheet 182_105.pdf

References for GluA2 - 182 105

Neurons undergo pathogenic metabolic reprogramming in models of familial ALS.
Riechers SP, Mojsilovic-Petrovic J, Belton TB, Chakrabarty RP, Garjani M, Medvedeva V, Dalton C, Wong YC, Chandel NS, Dienel G, Kalb RG, et al.
Molecular metabolism (2022) 60: 101468. 182 105 ICC; tested species: rat
Hemisynapse Formation Between Target Astrocytes and Cortical Neuron Axons in vitro.
Teng Z, Gottmann K
Frontiers in molecular neuroscience (2022) 15: 829506. 182 105 ICC; tested species: mouse
Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Nature (2021) 5947863: 454-458. 182 105 ICC; tested species: rat
Differential Scaling of Synaptic Molecules within Functional Zones of an Excitatory Synapse during Homeostatic Plasticity.
Venkatesan S, Subramaniam S, Rajeev P, Chopra Y, Jose M, Nair D
eNeuro (2020) 72: . 182 105 ICC; tested species: rat
Age-related dysregulation of homeostatic control in neuronal microcircuits.
Radulescu CI, Doostdar N, Zabouri N, Melgosa-Ecenarro L, Wang X, Sadeh S, Pavlidi P, Airey J, Kopanitsa M, Clopath C, Barnes SJ, et al.
Nature neuroscience (2023) 2612: 2158-2170. 182 105 IHC; tested species: mouse
Cat. No.: 182 105
Amount: 50 µg
Price: $465.00
Neurons undergo pathogenic metabolic reprogramming in models of familial ALS.
Riechers SP, Mojsilovic-Petrovic J, Belton TB, Chakrabarty RP, Garjani M, Medvedeva V, Dalton C, Wong YC, Chandel NS, Dienel G, Kalb RG, et al.
Molecular metabolism (2022) 60: 101468. 182 105 ICC; tested species: rat
Hemisynapse Formation Between Target Astrocytes and Cortical Neuron Axons in vitro.
Teng Z, Gottmann K
Frontiers in molecular neuroscience (2022) 15: 829506. 182 105 ICC; tested species: mouse
Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Nature (2021) 5947863: 454-458. 182 105 ICC; tested species: rat
Differential Scaling of Synaptic Molecules within Functional Zones of an Excitatory Synapse during Homeostatic Plasticity.
Venkatesan S, Subramaniam S, Rajeev P, Chopra Y, Jose M, Nair D
eNeuro (2020) 72: . 182 105 ICC; tested species: rat
Age-related dysregulation of homeostatic control in neuronal microcircuits.
Radulescu CI, Doostdar N, Zabouri N, Melgosa-Ecenarro L, Wang X, Sadeh S, Pavlidi P, Airey J, Kopanitsa M, Clopath C, Barnes SJ, et al.
Nature neuroscience (2023) 2612: 2158-2170. 182 105 IHC; tested species: mouse
Background

Ionotropic glutamate receptors (iGluRs) mediate rapid excitatory neurotransmission in the mammalian CNS. They can be subdivided into three major groups, the AMPA/GluA, NMDA/GluN and kainate/GluK receptors (KARs). mRNAs coding for glutamate receptors are substrates for an adenosine deaminase acting on RNA (ADAR) that increases the diversity of these proteins.
Glutamate receptors of the AMPA subtype are monovalent cation channels and are composed of the four AMPA subunits GluA 1, GluA 2, GluA 3, and GluA 4.