P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice.Alves M, de Diego-Garcia L, Vegliante G, Moreno O, Gil B, Ramos-Cabrer P, Mitra M, Martin AF, Menéndez-Méndez A, Wang Y, Strogulski NR, et al.
Theranostics (2025) 154: 1399-1419.
177 003 WB; tested species: mouse Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse line.von Mücke-Heim IA, Oldekamp J, Metzger MW, Kläffgen S, Tang H, Walser SM, Dedic N, Rammes G, Holsboer F, Wurst W, Deussing JM, et al.
Purinergic signalling (2025) : .
177 003 WB; tested species: mouse Spatiotemporal diversity in molecular and functional abnormalities in the mdx dystrophic brain.Pomeroy J, Borczyk M, Kawalec M, Hajto J, Carlson E, Svärd S, Verma S, Bareke E, Boratyńska-Jasińska A, Dymkowska D, Mellado-Ibáñez A, et al.
Molecular medicine (Cambridge, Mass.) (2025) 311: 108.
177 003 WB; tested species: mouse P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles.Rumney RMH, Róg J, Chira N, Kao AP, Al-Khalidi R, Górecki DC
Frontiers in pharmacology (2022) 13: 935804.
177 003 WB, ICC; KO verified; tested species: mouse iTRAQ-based proteomics implies inflammasome pathway activation in the prefrontal cortex of CSDS mice may influence resilience and susceptibility.Lan T, Bai M, Chen X, Wang Y, Li Y, Tian Y, He Y, Wu Z, Yu H, Chen Z, Chen C, et al.
Life sciences (2020) 262: 118501.
177 003 WB; tested species: mouse Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody.Kaczmarek-Hajek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, Bruzzone S, Engel T, Jooss T, Krautloher A, Schuster S, et al.
eLife (2018) 7: .
177 003 WB, IHC; tested species: mouse Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition.Young CNJ, Chira N, Róg J, Al-Khalidi R, Benard M, Galas L, Chan P, Vaudry D, Zablocki K, Górecki DC
Journal of molecular cell biology (2017) : .
177 003 WB; tested species: mouse A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.Young CN, Sinadinos A, Lefebvre A, Chan P, Arkle S, Vaudry D, Gorecki DC
Autophagy (2015) 111: 113-30.
177 003 WB; KO verified P2RX7 purinoceptor: a therapeutic target for ameliorating the symptoms of duchenne muscular dystrophy.Sinadinos A, Young CN, Al-Khalidi R, Teti A, Kalinski P, Mohamad S, Floriot L, Henry T, Tozzi G, Jiang T, Wurtz O, et al.
PLoS medicine (2015) 1210: e1001888.
177 003 ICC, WB Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts.Masin M, Young C, Lim K, Barnes SJ, Xu XJ, Marschall V, Brutkowski W, Mooney ER, Gorecki DC, Murrell-Lagnado R
British journal of pharmacology (2012) 1654: 978-93.
177 003 WB P2X7 purinoceptor alterations in dystrophic mdx mouse muscles: relationship to pathology and potential target for treatment.Young CN, Brutkowski W, Lien CF, Arkle S, Lochmüller H, Zabłocki K, Górecki DC
Journal of cellular and molecular medicine (2012) 165: 1026-37.
177 003 WB 
