Synaptic Systems

Cat. No.: 174 103

Amount: 50 µg

Price: $380.00

Cat. No. 174 103	50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 1000 (AP-staining) gallery IP: not tested yet ICC: not tested yet IHC: not tested yet IHC-P: not tested yet
Immunogen	Recombinant protein corresponding to AA 38 to 119 from rat Doc2b (UniProt Id: P70610)
Reactivity	Reacts with: rat (P70610), mouse (P70169). Other species not tested yet.
Specificity	Specific for Doc 2b, no cross-reactivity to Doc 2a and Doc 2c. K.O. validated PubMed: 32347796
Data sheet	174_103.pdf

References for Doc2b - 174 103

Disease-linked mutations in Munc18-1 deplete synaptic Doc2.
Guiberson NGL, Black LS, Haller JE, Brukner A, Abramov D, Ahmad S, Xie YX, Sharma M, Burré J
Brain : a journal of neurology (2024) : . 174 103 WB; tested species: mouse

Munc13-1 is a Ca2+-phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission.
Lipstein N, Chang S, Lin KH, López-Murcia FJ, Neher E, Taschenberger H, Brose N
Neuron (2021) : . 174 103 WB; tested species: mouse

Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2.
Kreutzberger AJB, Kiessling V, Doyle CA, Schenk N, Upchurch CM, Elmer-Dixon M, Ward AE, Preobraschenski J, Hussein SS, Tomaka W, Seelheim P, et al.
eLife (2020) 9: . 174 103 WB; tested species: rat

Cat. No.: 174 103

Amount: 50 µg

Price: $380.00

Background

Protocols

Doc2b antibody - 174 103 K.O.

References for Doc2b - 174 103