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Neurofilament L antibody - 171 002

Neurofilaments are major neuronal intermediate filaments
Polyclonal rabbit antiserum
Cat. No.: 171 002
Amount: 200 µl
Price: $350.00
Cat. No. 171 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 200 gallery  
IHC-P/FFPE: 1 : 200 gallery  
Immunogen Recombinant protein corresponding to AA 1 to 376 from human Neurofilament L (UniProt Id: P07196) with AA 200-292 missing. Immunogen corresponds to AA 1 to 284 in AAH66952.1
Reactivity Reacts with: human (P07196), rat (P19527), mouse (P08551).
Other species not tested yet.
Specificity Specific for neurofilament L.
Data sheet 171_002.pdf

References for Neurofilament L - 171 002

Impaired Neurofilament Integrity and Neuronal Morphology in Different Models of Focal Cerebral Ischemia and Human Stroke Tissue.
Mages B, Aleithe S, Altmann S, Blietz A, Nitzsche B, Barthel H, Horn AKE, Hobusch C, Härtig W, Krueger M, Michalski D, et al.
Frontiers in cellular neuroscience (2018) 12: 161. 171 002 WB, IHC; tested species: human,mouse,rat
Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation.
Patzke C, Acuna C, Giam LR, Wernig M, Südhof TC
The Journal of experimental medicine (2016) 2134: 499-515. 171 002 WB, ICC; tested species: mouse
Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.
Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D'Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, et al.
The EMBO journal (2018) 371: 139-159. 171 002 ICC; tested species: mouse
Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation.
Patzke C, Acuna C, Giam LR, Wernig M, Südhof TC
The Journal of experimental medicine (2016) 2134: 499-515. 171 002 WB, ICC; tested species: mouse
Differential antiapoptotic effect of erythropoietin on undifferentiated and retinoic acid-differentiated SH-SY5Y cells.
Wenker SD, Chamorro ME, Vota DM, Callero MA, Vittori DC, Nesse AB
Journal of cellular biochemistry (2010) 1101: 151-61. 171 002 ICC
Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia.
Oury J, Zhang W, Leloup N, Koide A, Corrado AD, Ketavarapu G, Hattori T, Koide S, Burden SJ
Nature (2021) : . 171 002 IHC; tested species: mouse
Phrenic-specific transcriptional programs shape respiratory motor output.
Vagnozzi AN, Garg K, Dewitz C, Moore MT, Cregg JM, Jeannotte L, Zampieri N, Landmesser LT, Philippidou P
eLife (2020) 9: . 171 002 IHC; tested species: mouse
Neuropathological findings suggestive for a stroke in an alpaca (Vicugna pacos).
Schöniger S, Schütze E, Michalski D, Puchta J, Kaiser M, Härtig W
Acta veterinaria Scandinavica (2019) 611: 1. 171 002 IHC
MACF1 links Rapsyn to microtubule- and actin-binding proteins to maintain neuromuscular synapses.
Oury J, Liu Y, Töpf A, Todorovic S, Hoedt E, Preethish-Kumar V, Neubert TA, Lin W, Lochmüller H, Burden SJ
The Journal of cell biology (2019) : . 171 002 IHC; tested species: mouse
Vezatin is Required for the Maturation of the Neuromuscular Synapse.
Koppel N, Friese MB, Cardasis HL, Neubert TA, Burden SJ
Molecular biology of the cell (2019) : mbcE19060313. 171 002 IHC; tested species: mouse
Impaired Neurofilament Integrity and Neuronal Morphology in Different Models of Focal Cerebral Ischemia and Human Stroke Tissue.
Mages B, Aleithe S, Altmann S, Blietz A, Nitzsche B, Barthel H, Horn AKE, Hobusch C, Härtig W, Krueger M, Michalski D, et al.
Frontiers in cellular neuroscience (2018) 12: 161. 171 002 WB, IHC; tested species: human,mouse,rat
Postnatal Development and Distribution of Sympathetic Innervation in Mouse Skeletal Muscle.
Straka T, Vita V, Prokshi K, Hörner SJ, Khan MM, Pirazzini M, Williams MPI, Hafner M, Zaglia T, Rudolf R
International journal of molecular sciences (2018) 197: . 171 002 IHC; tested species: mouse
Up-regulation of neurofilament light chains is associated with diminished immunoreactivities for MAP2 and tau after ischemic stroke in rodents and in a human case.
Härtig W, Krueger M, Hofmann S, Preißler H, Märkel M, Frydrychowicz C, Mueller WC, Bechmann I, Michalski D
Journal of chemical neuroanatomy (2016) 78: 140-148. 171 002 IHC
Increasing MuSK activity delays denervation and improves motor function in ALS mice.
Pérez-García MJ, Burden SJ
Cell reports (2012) 23: 497-502. 171 002 IHC
Topoisomerase IIβ Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs.
Edmond M, Hanley O, Philippidou P
eNeuro () 46: . 171 002 IHC; tested species: mouse
Gene Dosage Dependent Aggravation of the Neurological Phenotype in the 5XFAD Mouse Model of Alzheimer's Disease.
Richard BC, Kurdakova A, Baches S, Bayer TA, Weggen S, Wirths O
Journal of Alzheimer's disease : JAD (2015) 454: 1223-36. 171 002 IHC-P
Cat. No.: 171 002
Quantity: 200 µl
Price: $350.00
Impaired Neurofilament Integrity and Neuronal Morphology in Different Models of Focal Cerebral Ischemia and Human Stroke Tissue.
Mages B, Aleithe S, Altmann S, Blietz A, Nitzsche B, Barthel H, Horn AKE, Hobusch C, Härtig W, Krueger M, Michalski D, et al.
Frontiers in cellular neuroscience (2018) 12: 161. 171 002 WB, IHC; tested species: human,mouse,rat
Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation.
Patzke C, Acuna C, Giam LR, Wernig M, Südhof TC
The Journal of experimental medicine (2016) 2134: 499-515. 171 002 WB, ICC; tested species: mouse
Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.
Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D'Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, et al.
The EMBO journal (2018) 371: 139-159. 171 002 ICC; tested species: mouse
Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation.
Patzke C, Acuna C, Giam LR, Wernig M, Südhof TC
The Journal of experimental medicine (2016) 2134: 499-515. 171 002 WB, ICC; tested species: mouse
Differential antiapoptotic effect of erythropoietin on undifferentiated and retinoic acid-differentiated SH-SY5Y cells.
Wenker SD, Chamorro ME, Vota DM, Callero MA, Vittori DC, Nesse AB
Journal of cellular biochemistry (2010) 1101: 151-61. 171 002 ICC
Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia.
Oury J, Zhang W, Leloup N, Koide A, Corrado AD, Ketavarapu G, Hattori T, Koide S, Burden SJ
Nature (2021) : . 171 002 IHC; tested species: mouse
Phrenic-specific transcriptional programs shape respiratory motor output.
Vagnozzi AN, Garg K, Dewitz C, Moore MT, Cregg JM, Jeannotte L, Zampieri N, Landmesser LT, Philippidou P
eLife (2020) 9: . 171 002 IHC; tested species: mouse
Neuropathological findings suggestive for a stroke in an alpaca (Vicugna pacos).
Schöniger S, Schütze E, Michalski D, Puchta J, Kaiser M, Härtig W
Acta veterinaria Scandinavica (2019) 611: 1. 171 002 IHC
MACF1 links Rapsyn to microtubule- and actin-binding proteins to maintain neuromuscular synapses.
Oury J, Liu Y, Töpf A, Todorovic S, Hoedt E, Preethish-Kumar V, Neubert TA, Lin W, Lochmüller H, Burden SJ
The Journal of cell biology (2019) : . 171 002 IHC; tested species: mouse
Vezatin is Required for the Maturation of the Neuromuscular Synapse.
Koppel N, Friese MB, Cardasis HL, Neubert TA, Burden SJ
Molecular biology of the cell (2019) : mbcE19060313. 171 002 IHC; tested species: mouse
Impaired Neurofilament Integrity and Neuronal Morphology in Different Models of Focal Cerebral Ischemia and Human Stroke Tissue.
Mages B, Aleithe S, Altmann S, Blietz A, Nitzsche B, Barthel H, Horn AKE, Hobusch C, Härtig W, Krueger M, Michalski D, et al.
Frontiers in cellular neuroscience (2018) 12: 161. 171 002 WB, IHC; tested species: human,mouse,rat
Postnatal Development and Distribution of Sympathetic Innervation in Mouse Skeletal Muscle.
Straka T, Vita V, Prokshi K, Hörner SJ, Khan MM, Pirazzini M, Williams MPI, Hafner M, Zaglia T, Rudolf R
International journal of molecular sciences (2018) 197: . 171 002 IHC; tested species: mouse
Up-regulation of neurofilament light chains is associated with diminished immunoreactivities for MAP2 and tau after ischemic stroke in rodents and in a human case.
Härtig W, Krueger M, Hofmann S, Preißler H, Märkel M, Frydrychowicz C, Mueller WC, Bechmann I, Michalski D
Journal of chemical neuroanatomy (2016) 78: 140-148. 171 002 IHC
Increasing MuSK activity delays denervation and improves motor function in ALS mice.
Pérez-García MJ, Burden SJ
Cell reports (2012) 23: 497-502. 171 002 IHC
Topoisomerase IIβ Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs.
Edmond M, Hanley O, Philippidou P
eNeuro () 46: . 171 002 IHC; tested species: mouse
Gene Dosage Dependent Aggravation of the Neurological Phenotype in the 5XFAD Mouse Model of Alzheimer's Disease.
Richard BC, Kurdakova A, Baches S, Bayer TA, Weggen S, Wirths O
Journal of Alzheimer's disease : JAD (2015) 454: 1223-36. 171 002 IHC-P
Background
Neurofilaments are exclusively expressed in nerve cells and are the major structural component of large-diameter myelinated axons. They are predominatly composed of three proteins, Neurofilament H, L and M and are among the most highly phosphorylated neuronal proteins.