Tailor-made Antibodies
and Tools for Life Science
quick order | cart
?
|
login
Home|||||Technical Support
Home > Products > 162 202

Shank2 antibody - 162 202 K.O.

Shanks are multidomain proteins of the postsynaptic density
Rabbit polyclonal antiserum
Cat. No.: 162 202
Amount: 200 µl
Price: $355.00
Cat. No. 162 202 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 (see remarks) gallery  
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to residues near the carboxy terminus of rat Shank2 (UniProt Id: Q9QX74)
Reactivity Reacts with: rat (Q9QX74), mouse (Q80Z38).
Other species not tested yet.
Specificity K.O. validated PubMed: 29572432
Remarks

IHC: This antibody requires mild fixation.
Data sheet 162_202.pdf

References for Shank2 - 162 202

Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring.
Mirabella F, Desiato G, Mancinelli S, Fossati G, Rasile M, Morini R, Markicevic M, Grimm C, Amegandjin C, Termanini A, Peano C, et al.
Immunity (2021) 5411: 2611-2631.e8. 162 202 WB; tested species: mouse
Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons.
Chen ST, Lai WJ, Zhang WJ, Chen QP, Zhou LB, So KF, Shi LL
Neural regeneration research (2020) 1512: 2335-2343. 162 202 WB, ICC; KD verified; tested species: human
Syndapin I Loss-of-Function in Mice Leads to Schizophrenia-Like Symptoms.
Koch N, Koch D, Krueger S, Tröger J, Sabanov V, Ahmed T, McMillan LE, Wolf D, Montag D, Kessels MM, Balschun D, et al.
Cerebral cortex (New York, N.Y. : 1991) (2020) : . 162 202 WB; tested species: mouse
The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.
Filipello F, Morini R, Corradini I, Zerbi V, Canzi A, Michalski B, Erreni M, Markicevic M, Starvaggi-Cucuzza C, Otero K, Piccio L, et al.
Immunity (2018) : . 162 202 WB; tested species: mouse
Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin.
Fossati G, Pozzi D, Canzi A, Mirabella F, Valentino S, Morini R, Ghirardini E, Filipello F, Moretti M, Gotti C, Annis DS, et al.
The EMBO journal (2018) : . 162 202 WB; tested species: mouse
Early Exposure to a High-Fat Diet Impacts on Hippocampal Plasticity: Implication of Microglia-Derived Exosome-like Extracellular Vesicles.
Vinuesa A, Bentivegna M, Calfa G, Filipello F, Pomilio C, Bonaventura MM, Lux-Lantos V, Matzkin ME, Gregosa A, Presa J, Matteoli M, et al.
Molecular neurobiology (2018) : . 162 202 WB; tested species: mouse
Cell-Type-Specific Shank2 Deletion in Mice Leads to Differential Synaptic and Behavioral Phenotypes.
Kim R, Kim J, Chung C, Ha S, Lee S, Lee E, Yoo YE, Kim W, Shin W, Kim E
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3817: 4076-4092. 162 202 WB, IHC; KO verified; tested species: mouse
Shank2 Deletion in Parvalbumin Neurons Leads to Moderate Hyperactivity, Enhanced Self-Grooming and Suppressed Seizure Susceptibility in Mice.
Lee S, Lee E, Kim R, Kim J, Lee S, Park H, Yang E, Kim H, Kim E
Frontiers in molecular neuroscience (2018) 11: 209. 162 202 WB; KO verified; tested species: mouse
Cerebellar Shank2 Regulates Excitatory Synapse Density, Motor Coordination, and Specific Repetitive and Anxiety-Like Behaviors.
Ha S, Lee D, Cho YS, Chung C, Yoo YE, Kim J, Lee J, Kim W, Kim H, Bae YC, Tanaka-Yamamoto K, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3648: 12129-12143. 162 202 WB, IHC; KO verified; tested species: mouse
REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation.
Garcia-Manteiga JM, Bonfiglio S, Folladori L, Malosio ML, Lazarevic D, Stupka E, Cittaro D, Meldolesi J
Frontiers in cellular neuroscience (2015) 9: 438. 162 202 WB
The metabolite p-cresol impairs dendritic development, synaptogenesis, and synapse function in hippocampal neurons: Implications for autism spectrum disorder.
Guzmán-Salas S, Weber A, Malci A, Lin X, Herrera-Molina R, Cerpa W, Dorador C, Signorelli J, Zamorano P
Journal of neurochemistry (2022) 1614: 335-349. 162 202 ICC; tested species: rat
Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease.
Gabrielli M, Prada I, Joshi P, Falcicchia C, D'Arrigo G, Rutigliano G, Battocchio E, Zenatelli R, Tozzi F, Radeghieri A, Arancio O, et al.
Brain : a journal of neurology (2022) : . 162 202 ICC; tested species: mouse
The histone demethylase PHF8 regulates astrocyte differentiation and function.
Iacobucci S, Padilla N, Gabrielli M, Navarro C, Lombardi M, Vicioso-Mantis M, Verderio C, de la Cruz X, Martínez-Balbás MA
Development (Cambridge, England) (2021) 14812: . 162 202 ICC; tested species: mouse
Comparison of Multiscale Imaging Methods for Brain Research.
Tröger J, Hoischen C, Perner B, Monajembashi S, Barbotin A, Löschberger A, Eggeling C, Kessels MM, Qualmann B, Hemmerich P
Cells (2020) 96: . 162 202 ICC, IHC; tested species: mouse,rat
Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons.
Chen ST, Lai WJ, Zhang WJ, Chen QP, Zhou LB, So KF, Shi LL
Neural regeneration research (2020) 1512: 2335-2343. 162 202 WB, ICC; KD verified; tested species: human
Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations.
Prada I, Gabrielli M, Turola E, Iorio A, D'Arrigo G, Parolisi R, De Luca M, Pacifici M, Bastoni M, Lombardi M, Legname G, et al.
Acta neuropathologica (2018) 1354: 529-550. 162 202 ICC; tested species: mouse
Analysis of SUMO1-conjugation at synapses.
Daniel JA, Cooper BH, Palvimo JJ, Zhang FP, Brose N, Tirard M
eLife (2017) 6: . 162 202 ICC; tested species: mouse
Comparison of Multiscale Imaging Methods for Brain Research.
Tröger J, Hoischen C, Perner B, Monajembashi S, Barbotin A, Löschberger A, Eggeling C, Kessels MM, Qualmann B, Hemmerich P
Cells (2020) 96: . 162 202 ICC, IHC; tested species: mouse,rat
Light-sheet fluorescence expansion microscopy: fast mapping of neural circuits at super resolution.
Bürgers J, Pavlova I, Rodriguez-Gatica JE, Henneberger C, Oeller M, Ruland JA, Siebrasse JP, Kubitscheck U, Schwarz MK
Neurophotonics (2019) 61: 015005. 162 202 IHC; tested species: mouse
Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization.
Roesler MK, Lombino FL, Freitag S, Schweizer M, Hermans-Borgmeyer I, Schwarz JR, Kneussel M, Wagner W
Frontiers in cellular neuroscience (2019) 13: 330. 162 202 IHC; tested species: mouse
Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses.
Klotz L, Wendler O, Frischknecht R, Shigemoto R, Schulze H, Enz R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2019) : fj201901543R. 162 202 IHC; tested species: mouse
Cell-Type-Specific Shank2 Deletion in Mice Leads to Differential Synaptic and Behavioral Phenotypes.
Kim R, Kim J, Chung C, Ha S, Lee S, Lee E, Yoo YE, Kim W, Shin W, Kim E
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3817: 4076-4092. 162 202 WB, IHC; KO verified; tested species: mouse
Cerebellar Shank2 Regulates Excitatory Synapse Density, Motor Coordination, and Specific Repetitive and Anxiety-Like Behaviors.
Ha S, Lee D, Cho YS, Chung C, Yoo YE, Kim J, Lee J, Kim W, Kim H, Bae YC, Tanaka-Yamamoto K, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3648: 12129-12143. 162 202 WB, IHC; KO verified; tested species: mouse
Cat. No.: 162 202
Amount: 200 µl
Price: $355.00
Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring.
Mirabella F, Desiato G, Mancinelli S, Fossati G, Rasile M, Morini R, Markicevic M, Grimm C, Amegandjin C, Termanini A, Peano C, et al.
Immunity (2021) 5411: 2611-2631.e8. 162 202 WB; tested species: mouse
Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons.
Chen ST, Lai WJ, Zhang WJ, Chen QP, Zhou LB, So KF, Shi LL
Neural regeneration research (2020) 1512: 2335-2343. 162 202 WB, ICC; KD verified; tested species: human
Syndapin I Loss-of-Function in Mice Leads to Schizophrenia-Like Symptoms.
Koch N, Koch D, Krueger S, Tröger J, Sabanov V, Ahmed T, McMillan LE, Wolf D, Montag D, Kessels MM, Balschun D, et al.
Cerebral cortex (New York, N.Y. : 1991) (2020) : . 162 202 WB; tested species: mouse
The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.
Filipello F, Morini R, Corradini I, Zerbi V, Canzi A, Michalski B, Erreni M, Markicevic M, Starvaggi-Cucuzza C, Otero K, Piccio L, et al.
Immunity (2018) : . 162 202 WB; tested species: mouse
Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin.
Fossati G, Pozzi D, Canzi A, Mirabella F, Valentino S, Morini R, Ghirardini E, Filipello F, Moretti M, Gotti C, Annis DS, et al.
The EMBO journal (2018) : . 162 202 WB; tested species: mouse
Early Exposure to a High-Fat Diet Impacts on Hippocampal Plasticity: Implication of Microglia-Derived Exosome-like Extracellular Vesicles.
Vinuesa A, Bentivegna M, Calfa G, Filipello F, Pomilio C, Bonaventura MM, Lux-Lantos V, Matzkin ME, Gregosa A, Presa J, Matteoli M, et al.
Molecular neurobiology (2018) : . 162 202 WB; tested species: mouse
Cell-Type-Specific Shank2 Deletion in Mice Leads to Differential Synaptic and Behavioral Phenotypes.
Kim R, Kim J, Chung C, Ha S, Lee S, Lee E, Yoo YE, Kim W, Shin W, Kim E
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3817: 4076-4092. 162 202 WB, IHC; KO verified; tested species: mouse
Shank2 Deletion in Parvalbumin Neurons Leads to Moderate Hyperactivity, Enhanced Self-Grooming and Suppressed Seizure Susceptibility in Mice.
Lee S, Lee E, Kim R, Kim J, Lee S, Park H, Yang E, Kim H, Kim E
Frontiers in molecular neuroscience (2018) 11: 209. 162 202 WB; KO verified; tested species: mouse
Cerebellar Shank2 Regulates Excitatory Synapse Density, Motor Coordination, and Specific Repetitive and Anxiety-Like Behaviors.
Ha S, Lee D, Cho YS, Chung C, Yoo YE, Kim J, Lee J, Kim W, Kim H, Bae YC, Tanaka-Yamamoto K, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3648: 12129-12143. 162 202 WB, IHC; KO verified; tested species: mouse
REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation.
Garcia-Manteiga JM, Bonfiglio S, Folladori L, Malosio ML, Lazarevic D, Stupka E, Cittaro D, Meldolesi J
Frontiers in cellular neuroscience (2015) 9: 438. 162 202 WB
The metabolite p-cresol impairs dendritic development, synaptogenesis, and synapse function in hippocampal neurons: Implications for autism spectrum disorder.
Guzmán-Salas S, Weber A, Malci A, Lin X, Herrera-Molina R, Cerpa W, Dorador C, Signorelli J, Zamorano P
Journal of neurochemistry (2022) 1614: 335-349. 162 202 ICC; tested species: rat
Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease.
Gabrielli M, Prada I, Joshi P, Falcicchia C, D'Arrigo G, Rutigliano G, Battocchio E, Zenatelli R, Tozzi F, Radeghieri A, Arancio O, et al.
Brain : a journal of neurology (2022) : . 162 202 ICC; tested species: mouse
The histone demethylase PHF8 regulates astrocyte differentiation and function.
Iacobucci S, Padilla N, Gabrielli M, Navarro C, Lombardi M, Vicioso-Mantis M, Verderio C, de la Cruz X, Martínez-Balbás MA
Development (Cambridge, England) (2021) 14812: . 162 202 ICC; tested species: mouse
Comparison of Multiscale Imaging Methods for Brain Research.
Tröger J, Hoischen C, Perner B, Monajembashi S, Barbotin A, Löschberger A, Eggeling C, Kessels MM, Qualmann B, Hemmerich P
Cells (2020) 96: . 162 202 ICC, IHC; tested species: mouse,rat
Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons.
Chen ST, Lai WJ, Zhang WJ, Chen QP, Zhou LB, So KF, Shi LL
Neural regeneration research (2020) 1512: 2335-2343. 162 202 WB, ICC; KD verified; tested species: human
Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations.
Prada I, Gabrielli M, Turola E, Iorio A, D'Arrigo G, Parolisi R, De Luca M, Pacifici M, Bastoni M, Lombardi M, Legname G, et al.
Acta neuropathologica (2018) 1354: 529-550. 162 202 ICC; tested species: mouse
Analysis of SUMO1-conjugation at synapses.
Daniel JA, Cooper BH, Palvimo JJ, Zhang FP, Brose N, Tirard M
eLife (2017) 6: . 162 202 ICC; tested species: mouse
Comparison of Multiscale Imaging Methods for Brain Research.
Tröger J, Hoischen C, Perner B, Monajembashi S, Barbotin A, Löschberger A, Eggeling C, Kessels MM, Qualmann B, Hemmerich P
Cells (2020) 96: . 162 202 ICC, IHC; tested species: mouse,rat
Light-sheet fluorescence expansion microscopy: fast mapping of neural circuits at super resolution.
Bürgers J, Pavlova I, Rodriguez-Gatica JE, Henneberger C, Oeller M, Ruland JA, Siebrasse JP, Kubitscheck U, Schwarz MK
Neurophotonics (2019) 61: 015005. 162 202 IHC; tested species: mouse
Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization.
Roesler MK, Lombino FL, Freitag S, Schweizer M, Hermans-Borgmeyer I, Schwarz JR, Kneussel M, Wagner W
Frontiers in cellular neuroscience (2019) 13: 330. 162 202 IHC; tested species: mouse
Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses.
Klotz L, Wendler O, Frischknecht R, Shigemoto R, Schulze H, Enz R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2019) : fj201901543R. 162 202 IHC; tested species: mouse
Cell-Type-Specific Shank2 Deletion in Mice Leads to Differential Synaptic and Behavioral Phenotypes.
Kim R, Kim J, Chung C, Ha S, Lee S, Lee E, Yoo YE, Kim W, Shin W, Kim E
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3817: 4076-4092. 162 202 WB, IHC; KO verified; tested species: mouse
Cerebellar Shank2 Regulates Excitatory Synapse Density, Motor Coordination, and Specific Repetitive and Anxiety-Like Behaviors.
Ha S, Lee D, Cho YS, Chung C, Yoo YE, Kim J, Lee J, Kim W, Kim H, Bae YC, Tanaka-Yamamoto K, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3648: 12129-12143. 162 202 WB, IHC; KO verified; tested species: mouse
WB
ICC
IHC
Other products for this target