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Homer1b/c antibody - 160 018

Homer1 , 2 and 3 are post synaptic density (PSD) proteins involved in the targeting of glutamate receptors
Rabbit monoclonal recombinant IgG
Cat. No.: 160 018
Amount: 50 µg
Price: $415.00
Cat. No. 160 018 50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
WB: 1 : 1000 (AP-staining) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 1000 gallery  
Clone Rb72G2
Subtype IgG1 (κ light chain)
Immunogen Recombinant protein corresponding to the C-terminal half of human Homer1b. (UniProt Id: Q86YM7-1)
Reactivity Reacts with: human (Q86YM7-1), mouse (Q9Z2Y3), rat (Q9Z214).
Other species not tested yet.
Specificity Specific for homer 1b and 1c; no cross-reactivity to homer 1a.

This antibody is a chimeric antibody based on the monoclonal mouse antibody SY-72G2. The constant regions of the heavy and light chains have been replaced with rabbit specific sequences. The antibody can therefore be used with standard anti-rabbit secondary reagents. The antibody has been expressed in mammalian cells.

Data sheet 160_018.pdf
Cat. No.: 160 018
Amount: 50 µg
Price: $415.00

Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer 1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.