Cat. No.: 160 018
Amount: 50 µg
Price:
$420.00
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| Cat. No. 160 018 |
50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | Rb72G2 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Recombinant protein corresponding to the C-terminal half of human Homer1b. (UniProt Id: Q86YM7-1) |
| Reactivity |
Reacts with: human (Q86YM7-1), mouse (Q9Z2Y3), rat (Q9Z214). Other species not tested yet. |
| Specificity | Specific for homer 1b and 1c; no cross-reactivity to homer 1a. |
| Remarks |
This antibody is a chimeric antibody based on the monoclonal mouse antibody SY-72G2. The constant regions of the heavy and light chains have been replaced with rabbit specific sequences. The antibody can therefore be used with standard anti-rabbit secondary reagents. The antibody has been expressed in mammalian cells. |
| Data sheet | 160_018.pdf |
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Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.