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Arc antibody - 156 017

Arc is a cytoskeleton-associated protein involved in neuronal plasticity
Rat monoclonal purified IgG
Cat. No.: 156 017
Amount: 100 µg
Price: $415.00
Cat. No. 156 017 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: not tested yet gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 200 gallery  
EM: not tested yet
Clone SY-150H10
Subtype IgG2a (κ light chain)
Immunogen Full length recombinant mouse Arc. (UniProt Id: Q9WV31)
Reactivity Reacts with: mouse (Q9WV31), rat (Q63053).
Other species not tested yet.
Data sheet 156_017.pdf
Cat. No.: 156 017
Amount: 100 µg
Price: $415.00
Immediate-early genes (IEGs) are rapidely induced after patterned synaptic activity. Genes that are involved in this complex response code for transcription and growth factors, metabolic and signaling enzymes, small GTP binding proteins and structural proteins. Some of these proteins may play a crucial role in long term plasticity which is important for learning processes.
The activity regulated cytoskeleton associated protein Arc or Arg 3.1 is enriched in dendrites and colocalizes with F-Actin. Direct interaction of Arc with actin has also been demonstrated by biochemical studies.