Synaptic Systems

Cat. No.: 156 017

Amount: 100 µg

Price: $415.00

Cat. No. 156 017	100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 1000 (AP staining) gallery IP: not tested yet ICC: 1 : 500 gallery IHC: 1 : 500 gallery IHC-P: 1 : 200 gallery EM: not tested yet
Clone	SY-150H10
Subtype	IgG2a (κ light chain)
Immunogen	Full length recombinant mouse Arc. (UniProt Id: Q9WV31)
Reactivity	Reacts with: mouse (Q9WV31), rat (Q63053). Other species not tested yet.
Data sheet	156_017.pdf

Cat. No.: 156 017

Amount: 100 µg

Price: $415.00

ICC

IHC

IHC-P

Background

Immediate-early genes (IEGs) are rapidely induced after patterned synaptic activity. Genes that are involved in this complex response code for transcription and growth factors, metabolic and signaling enzymes, small GTP binding proteins and structural proteins. Some of these proteins may play a crucial role in long term plasticity which is important for learning processes.
The activity regulated cytoskeleton associated protein Arc or Arg 3.1 is enriched in dendrites and colocalizes with F-Actin. Direct interaction of Arc with actin has also been demonstrated by biochemical studies.

1 ) Larsen MH et al., Brain Res. (2005)
2 ) McIntyre CK et al., Proc. Natl. Acad. Sci. U.S.A. (2005)
3 ) Chawla MK et al., Hippocampus (2005)
4 ) Vazdarjanova A et al., J. Neurosci. (2002)
5 ) Guzowski JF et al., J. Neurosci. (2000)

Protocols

ICC

IHC

IHC-P

Other products for this target

Arc antibody - 156 017