Home|||||||Technical Support|

Arc - 156 011

A cytoskeleton-associated protein involved in neuronal plasticity
Monoclonal mouse purified IgG
Cat. No.: 156 011
Amount: 100 µg
Price: $415.00
Cat. No. 156 011 100 µg purified IgG, lyophilized. Azide was added before lyophilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: not recommended
IP: yes
ICC: not tested yet
IHC: not tested yet
IHC-P/FFPE: not tested yet
ELISA: yes (see remarks)
Clone 48B2
Subtype IgG2b (κ light chain)
Immunogen Recombinant protein corresponding to AA 1 to 396 from mouse Arc (UniProt Id: Q9WV31)
Epitop Epitop: AA 1 to 214 from mouse Arc (UniProt Id: Q9WV31)
Reactivity Reacts with: rat (Q63053), mouse (Q9WV31).
Other species not tested yet.
Specificity Specific for Arc.
Matching control protein/peptide 156-0P
Remarks

ELISA: Suitable as capture antibody for sandwich-ELISA with cat. no. 156 003 as detector antibody. The ELISA-protocol for membrane proteins is recommended.

Data sheet 156_011.pdf

References for Arc - 156 011

Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 156 011 ELISA
Cat. No.: 156 011
Quantity: 100 µg
Price: $415.00
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 156 011 ELISA
Background
Immediate-early genes (IEGs) are rapidely induced after patterned synaptic activity. Genes that are involved in this complex response code for transcription and growth factors, metabolic and signaling enzymes, small GTP binding proteins and structural proteins. Some of these proteins may play a crucial role in long term plasticity which is important for learning processes.
The activity regulated cytoskeleton associated protein Arc or Arg 3.1 is enriched in dendrites and colocalizes with F-Actin. Direct interaction of Arc with actin has also been demonstrated by biochemical studies.