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Home > Products > 156 008

Arc antibody - 156 008

Arc is a cytoskeleton-associated protein involved in neuronal plasticity
Rabbit monoclonal recombinant IgG
Cat. No.: 156 008
Amount: 50 µg
Price: $415.00
Cat. No. 156 008 50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP-staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: yes gallery  
Clone Rb150H10
Subtype IgG1 (κ light chain)
Immunogen Full length recombinant mouse Arc (UniProt Id: Q9WV31)
Reactivity Reacts with: mouse (Q9WV31), rat (Q63053).
Other species not tested yet.
Remarks

This antibody is a chimeric antibody based on the monoclonal rat antibody SY-150H10. The constant regions of the heavy and light chains have been replaced with rabbit specific sequences. The antibody can therefore be used with standard anti-rabbit secondary reagents. The antibody has been expressed in mammalian cells.
Data sheet 156_008.pdf
Cat. No.: 156 008
Amount: 50 µg
Price: $415.00
WB
ICC
ICC
IHC
IHC
IHC
IHC
IHC-P
IHC-P
Background
Immediate-early genes (IEGs) are rapidely induced after patterned synaptic activity. Genes that are involved in this complex response code for transcription and growth factors, metabolic and signaling enzymes, small GTP binding proteins and structural proteins. Some of these proteins may play a crucial role in long term plasticity which is important for learning processes.
The activity regulated cytoskeleton associated protein Arc or Arg 3.1 is enriched in dendrites and colocalizes with F-Actin. Direct interaction of Arc with actin has also been demonstrated by biochemical studies.
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