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Home > Products > 156 005

Arc antibody - 156 005 K.O.

Arc is a cytoskeleton-associated protein involved in neuronal plasticity
Guinea pig polyclonal purified antibody
Cat. No.: 156 005
Amount: 100 µl
Price: $460.00
Cat. No. 156 005 100 µl specific antibody, lyophilized. Affinity purified with the immunogen. For reconstitution add 100 µl H2O. Then aliquot and store at -20°C to -80°C until use.
Applications
 
WB: 1 : 1000 (AP-staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: not tested yet
Immunogen Full-length recombinant mouse Arc (UniProt Id: Q9WV31)
Reactivity Reacts with: rat (Q63053), mouse (Q9WV31).
Other species not tested yet.
Specificity Specific for arc. K.O. validated
Data sheet 156_005.pdf

References for Arc - 156 005

Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory.
Zhao WN, Ghosh B, Tyler M, Lalonde J, Joseph NF, Kosaric N, Fass DM, Tsai LH, Mazitschek R, Haggarty SJ
ACS chemical neuroscience (2018) : . 156 005 ICC; tested species: mouse
Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells.
Parylak SL, Qiu F, Linker SB, Gallina IS, Lim CK, Preciado D, McDonald AH, Zhou X, Gage FH
Hippocampus (2023) 334: 412-423. 156 005 IHC; tested species: mouse
A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons.
Jaeger BN, Linker SB, Parylak SL, Barron JJ, Gallina IS, Saavedra CD, Fitzpatrick C, Lim CK, Schafer ST, Lacar B, Jessberger S, et al.
Nature communications (2018) 91: 3084. 156 005 IHC; tested species: mouse
Distinct synaptic and neurochemical changes to the granule cell-CA3 projection in Bassoon mutant mice.
Dieni S, Nestel S, Sibbe M, Frotscher M, Hellwig S
Frontiers in synaptic neuroscience (2015) 7: 18. 156 005 IHC; tested species: mouse
Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering.
Vukovic J, Borlikova GG, Ruitenberg MJ, Robinson GJ, Sullivan RK, Walker TL, Bartlett PF
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3315: 6603-13. 156 005 IHC; tested species: mouse
BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons.
Dieni S, Matsumoto T, Dekkers M, Rauskolb S, Ionescu MS, Deogracias R, Gundelfinger ED, Kojima M, Nestel S, Frotscher M, Barde YA, et al.
The Journal of cell biology (2012) 1966: 775-88. 156 005 IHC
Cat. No.: 156 005
Amount: 100 µl
Price: $460.00
Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory.
Zhao WN, Ghosh B, Tyler M, Lalonde J, Joseph NF, Kosaric N, Fass DM, Tsai LH, Mazitschek R, Haggarty SJ
ACS chemical neuroscience (2018) : . 156 005 ICC; tested species: mouse
Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells.
Parylak SL, Qiu F, Linker SB, Gallina IS, Lim CK, Preciado D, McDonald AH, Zhou X, Gage FH
Hippocampus (2023) 334: 412-423. 156 005 IHC; tested species: mouse
A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons.
Jaeger BN, Linker SB, Parylak SL, Barron JJ, Gallina IS, Saavedra CD, Fitzpatrick C, Lim CK, Schafer ST, Lacar B, Jessberger S, et al.
Nature communications (2018) 91: 3084. 156 005 IHC; tested species: mouse
Distinct synaptic and neurochemical changes to the granule cell-CA3 projection in Bassoon mutant mice.
Dieni S, Nestel S, Sibbe M, Frotscher M, Hellwig S
Frontiers in synaptic neuroscience (2015) 7: 18. 156 005 IHC; tested species: mouse
Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering.
Vukovic J, Borlikova GG, Ruitenberg MJ, Robinson GJ, Sullivan RK, Walker TL, Bartlett PF
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3315: 6603-13. 156 005 IHC; tested species: mouse
BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons.
Dieni S, Matsumoto T, Dekkers M, Rauskolb S, Ionescu MS, Deogracias R, Gundelfinger ED, Kojima M, Nestel S, Frotscher M, Barde YA, et al.
The Journal of cell biology (2012) 1966: 775-88. 156 005 IHC
WB
ICC
IHC
Background
Immediate-early genes (IEGs) are rapidely induced after patterned synaptic activity. Genes that are involved in this complex response code for transcription and growth factors, metabolic and signaling enzymes, small GTP binding proteins and structural proteins. Some of these proteins may play a crucial role in long term plasticity which is important for learning processes.
The activity regulated cytoskeleton associated protein Arc or Arg 3.1 is enriched in dendrites and colocalizes with F-Actin. Direct interaction of Arc with actin has also been demonstrated by biochemical studies.
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