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Arc - 156-0P

A cytoskeleton-associated protein involved in neuronal plasticity
control protein
Cat. No.: 156-0P
Amount: 100 µg
Price: $90.00
Cat. No. 156-0P 100 µg protein, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in TBS. Then aliquot and store at -20°C to -80°C until use.
Immunogen Recombinant protein corresponding to AA 1 to 396 from mouse Arc (UniProt Id: Q9WV31)
Recommended dilution Optimal concentrations should be determined by the end-user.
Matching antibodies 156 003, 156 004, 156 011
Remarks

This control protein consists of the full length recombinant protein that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of protein needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen.

Data sheet 156-0p.pdf
Cat. No.: 156-0P
Quantity: 100 µg
Price: $90.00
Background
Immediate-early genes (IEGs) are rapidely induced after patterned synaptic activity. Genes that are involved in this complex response code for transcription and growth factors, metabolic and signaling enzymes, small GTP binding proteins and structural proteins. Some of these proteins may play a crucial role in long term plasticity which is important for learning processes.
The activity regulated cytoskeleton associated protein Arc or Arg 3.1 is enriched in dendrites and colocalizes with F-Actin. Direct interaction of Arc with actin has also been demonstrated by biochemical studies.
Protocols