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Gephyrin - 147 004

A protein associated with inhibitory neurotransmitter receptors
Polyclonal Guinea pig antiserum
Cat. No.: 147 004
Amount: 100 µl
Price: 350.00 €
Cat. No. 147 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 5000 (AP staining) gallery  
IP: not tested yet
ICC: not recommended
IHC: not recommended
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 294 to 736 from rat Gephyrin (UniProt Id: Q03555)
Reactivity Reacts with: rat (Q03555), mouse (Q8BUV3).
Other species not tested yet.
Specificity Specific for gephyrin, detects all splice isoforms.
Matching control protein/peptide 147-1P
Remarks This antibody gives better results in WB than the rabbit antibody.
Data sheet 147_004.pdf

References for Gephyrin - 147 004

Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells.
Brown AM, Arancillo M, Lin T, Catt DR, Zhou J, Lackey EP, Stay TL, Zuo Z, White JJ, Sillitoe RV
Scientific reports (2019) 91: 1742. 147 004 IHC-P; tested species: mouse
Cat. No.: 147 004
Quantity: 100 µl
Price: 350.00 €
Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells.
Brown AM, Arancillo M, Lin T, Catt DR, Zhou J, Lackey EP, Stay TL, Zuo Z, White JJ, Sillitoe RV
Scientific reports (2019) 91: 1742. 147 004 IHC-P; tested species: mouse
Background

Gephyrin is a bifunctional protein which is essential for both synaptic clustering of inhibitory neurotransmitter receptors in the central nervous system and the biosynthesis of the molybdenum cofactor (MoCo) in peripheral tissues. It co-purifies with the inhibitory glycine receptor (GlyR) and is expressed abundantly in all brain areas which contain synapses.