Synaptic Systems

Cat. No.: 140 003

Amount: 50 µg

Price: $385.00

Cat. No. 140 003	50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 100 up to 1 : 1000 gallery IP: not tested yet ICC: 1 : 200 up to 1 : 500 gallery IHC: yes IHC-P: 1 : 500 gallery
Immunogen	Recombinant protein corresponding to AA 596 to 705 from rat Rim1 (UniProt Id: Q9JIR4)
Reactivity	Reacts with: human (Q86UR5), rat (Q9JIR4), mouse (Q99NE5), hamster, chicken, frog. Other species not tested yet.
Specificity	Specific for RIM 1 with weak cross reactivity to RIM 2. K.O. validated PubMed: 32521280
Data sheet	140_003.pdf

References for RIM1 - 140 003

Expression of synaptic proteins and development of dendritic spines in fetal and postnatal neocortex of the pig, the European wild boar Sus scrofa.
Sobierajski E, Czubay K, Schmidt MR, Wiedenski S, Rettschlag S, Beemelmans C, Beemelmans C, Wahle P
Brain structure & function (2025) 2302: 38. 140 003 WB; tested species: pig

Functional specificity of liquid-liquid phase separation at the synapse.
Guzikowski NJ, Kavalali ET
Nature communications (2024) 151: 10103. 140 003 WB; tested species: rat

Liprin-α proteins are master regulators of human presynapse assembly.
Marcó de la Cruz B, Campos J, Molinaro A, Xie X, Jin G, Wei Z, Acuna C, Sterky FH
Nature neuroscience (2024) : . 140 003 WB; tested species: human

Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance.
Singh N, Das B, Zhou J, Hu X, Yan R
Science advances (2022) 829: eabo3610. 140 003 WB; tested species: mouse

Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain.
Zhang MM, Geng AQ, Chen K, Wang J, Wang P, Qiu XT, Gu JX, Fan HW, Zhu DY, Yang SM, Chen QY, et al.
Neuron (2022) 11012: 1993-2008.e6. 140 003 WB; tested species: mouse

An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury.
Hilton BJ, Husch A, Schaffran B, Lin TC, Burnside ER, Dupraz S, Schelski M, Kim J, Müller JA, Schoch S, Imig C, et al.
Neuron (2021) : . 140 003 WB; KO verified; tested species: mouse

Actions of Rab27B-GTPase on mammalian central excitatory synaptic transmission.
Arias-Hervert ER, Xu N, Njus M, Murphy GG, Hou Y, Williams JA, Lentz SI, Ernst SA, Stuenkel EL
Physiological reports (2020) 89: e14428. 140 003 WB; tested species: mouse

ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Nyitrai H, Wang SSH, Kaeser PS
Cell reports (2020) 3110: 107712. 140 003 WB, ICC; KO verified; tested species: mouse

Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts.
Raja MK, Preobraschenski J, Del Olmo-Cabrera S, Martinez-Turrillas R, Jahn R, Perez-Otano I, Wesseling JF
eLife (2019) 8: . 140 003 WB; tested species: mouse

Canonical Wnt Signaling Modulates the Expression of Pre- and Postsynaptic Components in Different Temporal Patterns.
Martinez M, Torres VI, Vio CP, Inestrosa NC
Molecular neurobiology (2019) : . 140 003 WB; tested species: rat

Analysis of RIM Expression and Function at Mouse Photoreceptor Ribbon Synapses.
Löhner M, Babai N, Müller T, Gierke K, Atorf J, Joachimsthaler A, Peukert A, Martens H, Feigenspan A, Kremers J, Schoch S, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3733: 7848-7863. 140 003 WB, IHC; tested species: mouse

Analysis of SUMO1-conjugation at synapses.
Daniel JA, Cooper BH, Palvimo JJ, Zhang FP, Brose N, Tirard M
eLife (2017) 6: . 140 003 WB; tested species: mouse

Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn.
Cazares VA, Njus MM, Manly A, Saldate JJ, Subramani A, Ben-Simon Y, Sutton MA, Ashery U, Stuenkel EL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3644: 11208-11222. 140 003 WB; tested species: rat

RIM1/2-Mediated Facilitation of Cav1.4 Channel Opening Is Required for Ca2+-Stimulated Release in Mouse Rod Photoreceptors.
Grabner CP, Gandini MA, Rehak R, Le Y, Zamponi GW, Schmitz F
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3538: 13133-47. 140 003 IHC, WB

Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus.
Fernandes HB, Riordan S, Nomura T, Remmers CL, Kraniotis S, Marshall JJ, Kukreja L, Vassar R, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3516: 6544-53. 140 003 WB

Active zone protein expression changes at the key stages of cerebellar cortex neurogenesis in the rat.
Juranek JK, Mukherjee K, Siddiqui TJ, Kaplan BJ, Li JY, Ahnert-Hilger G, Jahn R, Calka J
Acta histochemica (2013) 1156: 616-25. 140 003 WB, ICC, IHC

RIM, Munc13, and Rab3A interplay in acrosomal exocytosis.
Bello OD, Zanetti MN, Mayorga LS, Michaut MA
Experimental cell research (2012) 3185: 478-88. 140 003 WB, ICC

Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site.
Limbach C, Laue MM, Wang X, Hu B, Thiede N, Hultqvist G, Kilimann MW
Proceedings of the National Academy of Sciences of the United States of America (2011) 10831: E392-401. 140 003 WB

Rab3a interacting molecule (RIM) and the tethering of pre-synaptic transmitter release site-associated CaV2.2 calcium channels.
Wong FK, Stanley EF
Journal of neurochemistry (2010) 1122: 463-73. 140 003 WB, IP; tested species: chicken

Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity.
Jüttner R, Moré MI, Das D, Babich A, Meier J, Henning M, Erdmann B, Mu Ller EC, Otto A, Grantyn R, Rathjen FG, et al.
Neuron (2005) 462: 233-45. 140 003 WB

Cat. No.: 140 003

Amount: 50 µg

Price: $385.00

ICC

IHC-P

Background

Protocols

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RIM1 antibody PDZ domain - 140 003 K.O.

References for RIM1 - 140 003