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Home > Products > 138 302

VMaT2 antibody C-terminus - 138 302

VMaT2 is a monoamine transporter in the membrane of small synaptic vesicles
Rabbit polyclonal antiserum
Cat. No.: 138 302
Amount: 200 µl
Price: $355.00
Cat. No. 138 302 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 100 up to 1 : 1000 (AP staining) (see remarks) gallery  
IP: not tested yet
ICC: 1 : 1000 (see remarks) gallery  
IHC: 1 : 500 gallery  
IHC-P: not tested yet
Immunogen Synthetic peptide corresponding to AA 496 to 515 from rat VMaT2 (UniProt Id: Q01827)
Reactivity Reacts with: rat (Q8BRU6).
Other species not tested yet.
Remarks

WB:  VMaT 2 aggregates after boiling, making it necessary to run SDS-PAGE with non-boiled samples.
ICC: Requires brief fixation with 4 % PFA for 2 min and subsequent ice cold methanol fixation for 10 min.
Data sheet 138_302.pdf

References for VMaT2 - 138 302

Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2.
Kreutzberger AJB, Kiessling V, Doyle CA, Schenk N, Upchurch CM, Elmer-Dixon M, Ward AE, Preobraschenski J, Hussein SS, Tomaka W, Seelheim P, et al.
eLife (2020) 9: . 138 302 WB; tested species: rat
Effects of sleep disruption on stress, nigrostriatal markers, and behavior in a chronic/progressive MPTP male mouse model of parkinsonism.
Xu M, Bohlen JK, Moore C, Nipper MA, Finn DA, Jones CE, Lim MM, Meshul CK
Journal of neuroscience research (2019) 9712: 1706-1719. 138 302 WB; tested species: mouse
Gender-dependent and genotype-sensitive monoaminergic changes induced by polychlorinated biphenyl 153 in the rat brain.
Dervola KS, Johansen EB, Walaas SI, Fonnum F
Neurotoxicology (2015) 50: 38-45. 138 302 WB
Amphetamine regulates NR2B expression in Go2α knockout mice and thereby sustains behavioral sensitization.
Brunk I, Sanchis-Segura C, Blex C, Perreau-Lenz S, Bilbao A, Spanagel R, Ahnert-Hilger G
Journal of neurochemistry (2010) 1151: 234-46. 138 302 WB; tested species: mouse
Chronic low-level lead exposure affects the monoaminergic system in the mouse superior olivary complex.
Fortune T, Lurie DI
The Journal of comparative neurology (2009) 5135: 542-58. 138 302 IHC, WB; tested species: mouse
Deletion of Go2alpha abolishes cocaine-induced behavioral sensitization by disturbing the striatal dopamine system.
Brunk I, Blex C, Sanchis-Segura C, Sternberg J, Perreau-Lenz S, Bilbao A, Hörtnagl H, Baron J, Juranek J, Laube G, Birnbaumer L, et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2008) 2210: 3736-46. 138 302 WB
The first luminal domain of vesicular monoamine transporters mediates G-protein-dependent regulation of transmitter uptake.
Brunk I, Blex C, Rachakonda S, Höltje M, Winter S, Pahner I, Walther DJ, Ahnert-Hilger G
The Journal of biological chemistry (2006) 28144: 33373-85. 138 302 WB, ICC
On-Site Formation of Functional Dopaminergic Presynaptic Terminals on Neuroligin-2-Modified Gold-Coated Microspheres.
Cho W, Jung M, Yoon SH, Jeon J, Oh MA, Kim JY, Park M, Kang CM, Chung TD
ACS applied materials & interfaces (2024) 163: 3082-3092. 138 302 ICC; tested species: rat
Generation of self-organized autonomic ganglion organoids from fibroblasts.
Liu S, Xiang K, Yuan F, Xiang M
iScience (2023) 263: 106241. 138 302 ICC; tested species: mouse
Conversion of Astrocytes and Fibroblasts into Functional Noradrenergic Neurons.
Li S, Shi Y, Yao X, Wang X, Shen L, Rao Z, Yuan J, Liu Y, Zhou Z, Zhang Z, Liu F, et al.
Cell reports (2019) 283: 682-697.e7. 138 302 ICC; tested species: mouse
Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons.
Martí Y, Matthaeus F, Lau T, Schloss P
Molecular and cellular neurosciences (2017) 83: 37-45. 138 302 ICC; tested species: mouse
Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line.
Schmitt M, Dehay B, Bezard E, Garcia-Ladona FJ
Synapse (New York, N.Y.) (2016) 703: 71-86. 138 302 ICC
The first luminal domain of vesicular monoamine transporters mediates G-protein-dependent regulation of transmitter uptake.
Brunk I, Blex C, Rachakonda S, Höltje M, Winter S, Pahner I, Walther DJ, Ahnert-Hilger G
The Journal of biological chemistry (2006) 28144: 33373-85. 138 302 WB, ICC
Deficiency of Perry syndrome-associated p150Glued in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities.
Yu J, Yang X, Zheng J, Sgobio C, Sun L, Cai H
NPJ Parkinson's disease (2023) 91: 35. 138 302 IHC; tested species: mouse
Characterization of Dmrt3-derived Neurons Suggest a Role within Locomotor Circuits.
Perry S, Larhammar M, Vieillard J, Nagaraja C, Hilscher MM, Tafreshiha A, Rofo F, Caixeta FV, Kullander K
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 138 302 IHC; tested species: mouse
Development of early-born γ-Aminobutyric acid hub neurons in mouse hippocampus from embryogenesis to adulthood.
Villette V, Guigue P, Picardo MA, Sousa VH, Leprince E, Lachamp P, Malvache A, Tressard T, Cossart R, Baude A
The Journal of comparative neurology (2016) 52412: 2440-61. 138 302 IHC; tested species: mouse
Distribution of VGLUT3 in highly collateralized axons from the rat dorsal raphe nucleus as revealed by single-neuron reconstructions.
Gagnon D, Parent M
PloS one (2014) 92: e87709. 138 302 IHC; tested species: mouse
Sympathetic fiber sprouting in inflamed joints and adjacent skin contributes to pain-related behavior in arthritis.
Longo G, Osikowicz M, Ribeiro-da-Silva A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3324: 10066-74. 138 302 IHC
Cytoprotective effects of growth factors: BDNF more potent than GDNF in an organotypic culture model of Parkinson's disease.
Stahl K, Mylonakou MN, Skare Ø, Amiry-Moghaddam M, Torp R
Brain research (2011) 1378: 105-18. 138 302 IHC
Chronic low-level lead exposure affects the monoaminergic system in the mouse superior olivary complex.
Fortune T, Lurie DI
The Journal of comparative neurology (2009) 5135: 542-58. 138 302 IHC, WB; tested species: mouse
GABA is localized in dopaminergic synaptic vesicles in the rodent striatum.
Stensrud MJ, Puchades M, Gundersen V
Brain structure & function (2014) 2196: 1901-12. 138 302 EM; tested species: rat
Cat. No.: 138 302
Amount: 200 µl
Price: $355.00
Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2.
Kreutzberger AJB, Kiessling V, Doyle CA, Schenk N, Upchurch CM, Elmer-Dixon M, Ward AE, Preobraschenski J, Hussein SS, Tomaka W, Seelheim P, et al.
eLife (2020) 9: . 138 302 WB; tested species: rat
Effects of sleep disruption on stress, nigrostriatal markers, and behavior in a chronic/progressive MPTP male mouse model of parkinsonism.
Xu M, Bohlen JK, Moore C, Nipper MA, Finn DA, Jones CE, Lim MM, Meshul CK
Journal of neuroscience research (2019) 9712: 1706-1719. 138 302 WB; tested species: mouse
Gender-dependent and genotype-sensitive monoaminergic changes induced by polychlorinated biphenyl 153 in the rat brain.
Dervola KS, Johansen EB, Walaas SI, Fonnum F
Neurotoxicology (2015) 50: 38-45. 138 302 WB
Amphetamine regulates NR2B expression in Go2α knockout mice and thereby sustains behavioral sensitization.
Brunk I, Sanchis-Segura C, Blex C, Perreau-Lenz S, Bilbao A, Spanagel R, Ahnert-Hilger G
Journal of neurochemistry (2010) 1151: 234-46. 138 302 WB; tested species: mouse
Chronic low-level lead exposure affects the monoaminergic system in the mouse superior olivary complex.
Fortune T, Lurie DI
The Journal of comparative neurology (2009) 5135: 542-58. 138 302 IHC, WB; tested species: mouse
Deletion of Go2alpha abolishes cocaine-induced behavioral sensitization by disturbing the striatal dopamine system.
Brunk I, Blex C, Sanchis-Segura C, Sternberg J, Perreau-Lenz S, Bilbao A, Hörtnagl H, Baron J, Juranek J, Laube G, Birnbaumer L, et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2008) 2210: 3736-46. 138 302 WB
The first luminal domain of vesicular monoamine transporters mediates G-protein-dependent regulation of transmitter uptake.
Brunk I, Blex C, Rachakonda S, Höltje M, Winter S, Pahner I, Walther DJ, Ahnert-Hilger G
The Journal of biological chemistry (2006) 28144: 33373-85. 138 302 WB, ICC
On-Site Formation of Functional Dopaminergic Presynaptic Terminals on Neuroligin-2-Modified Gold-Coated Microspheres.
Cho W, Jung M, Yoon SH, Jeon J, Oh MA, Kim JY, Park M, Kang CM, Chung TD
ACS applied materials & interfaces (2024) 163: 3082-3092. 138 302 ICC; tested species: rat
Generation of self-organized autonomic ganglion organoids from fibroblasts.
Liu S, Xiang K, Yuan F, Xiang M
iScience (2023) 263: 106241. 138 302 ICC; tested species: mouse
Conversion of Astrocytes and Fibroblasts into Functional Noradrenergic Neurons.
Li S, Shi Y, Yao X, Wang X, Shen L, Rao Z, Yuan J, Liu Y, Zhou Z, Zhang Z, Liu F, et al.
Cell reports (2019) 283: 682-697.e7. 138 302 ICC; tested species: mouse
Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons.
Martí Y, Matthaeus F, Lau T, Schloss P
Molecular and cellular neurosciences (2017) 83: 37-45. 138 302 ICC; tested species: mouse
Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line.
Schmitt M, Dehay B, Bezard E, Garcia-Ladona FJ
Synapse (New York, N.Y.) (2016) 703: 71-86. 138 302 ICC
The first luminal domain of vesicular monoamine transporters mediates G-protein-dependent regulation of transmitter uptake.
Brunk I, Blex C, Rachakonda S, Höltje M, Winter S, Pahner I, Walther DJ, Ahnert-Hilger G
The Journal of biological chemistry (2006) 28144: 33373-85. 138 302 WB, ICC
Deficiency of Perry syndrome-associated p150Glued in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities.
Yu J, Yang X, Zheng J, Sgobio C, Sun L, Cai H
NPJ Parkinson's disease (2023) 91: 35. 138 302 IHC; tested species: mouse
Characterization of Dmrt3-derived Neurons Suggest a Role within Locomotor Circuits.
Perry S, Larhammar M, Vieillard J, Nagaraja C, Hilscher MM, Tafreshiha A, Rofo F, Caixeta FV, Kullander K
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 138 302 IHC; tested species: mouse
Development of early-born γ-Aminobutyric acid hub neurons in mouse hippocampus from embryogenesis to adulthood.
Villette V, Guigue P, Picardo MA, Sousa VH, Leprince E, Lachamp P, Malvache A, Tressard T, Cossart R, Baude A
The Journal of comparative neurology (2016) 52412: 2440-61. 138 302 IHC; tested species: mouse
Distribution of VGLUT3 in highly collateralized axons from the rat dorsal raphe nucleus as revealed by single-neuron reconstructions.
Gagnon D, Parent M
PloS one (2014) 92: e87709. 138 302 IHC; tested species: mouse
Sympathetic fiber sprouting in inflamed joints and adjacent skin contributes to pain-related behavior in arthritis.
Longo G, Osikowicz M, Ribeiro-da-Silva A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3324: 10066-74. 138 302 IHC
Cytoprotective effects of growth factors: BDNF more potent than GDNF in an organotypic culture model of Parkinson's disease.
Stahl K, Mylonakou MN, Skare Ø, Amiry-Moghaddam M, Torp R
Brain research (2011) 1378: 105-18. 138 302 IHC
Chronic low-level lead exposure affects the monoaminergic system in the mouse superior olivary complex.
Fortune T, Lurie DI
The Journal of comparative neurology (2009) 5135: 542-58. 138 302 IHC, WB; tested species: mouse
GABA is localized in dopaminergic synaptic vesicles in the rodent striatum.
Stensrud MJ, Puchades M, Gundersen V
Brain structure & function (2014) 2196: 1901-12. 138 302 EM; tested species: rat
WB
ICC
IHC
Background
Vesicular monoamine transporters VMaTs mediate the translocation of monoamines (serotonin, histamine, dopamine) from the cytoplasm into secretory vesicles by using a proton electrochemical gradient.
VMaTs are integral membrane proteins with 12 putative trans-membrane domains predicted by sequence analysis. Both, the N- and C-terminus of the proteins are located on the cytoplasmic side.
Two VMaT isoforms, VMaT 1 and VMaT 2, have been described. It has been proposed that VMaT 1 transports monoamines into large dense core vesicles (LDCVs), whereas VMaT 2 is needed for the loading of small synaptic vesicles (SSVs).
In rat VMaT 1 is expressed in the adrenal gland, while VMaT 2 is expressed in brain.
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