Cat. No.: 135 316
Amount: 200 µl
Price:
$365.00
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| Cat. No. 135 316 |
200 µl antibody, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of rat VGLUT 1 (UniProt Id: Q62634) |
| Reactivity |
Reacts with: rat (Q62634), mouse (Q3TXX4). Other species not tested yet. |
| Specificity | K.O. validated |
| Matching control protein/peptide | 135-0P |
| Remarks |
This antibody is highly recommended as a marker for glutamatergic nerve terminals. |
| Data sheet | 135_316.pdf |
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The vesicular glutamate transporter 1 VGLUT 1, also referred to as BNPI and SLC17A7, was originally identified as a brain specific phosphate transporter. Like the related VGLUT 2, VGLUT 1 is both necessary and sufficient for uptake and storage of glutamate and thus comprises the sole determinant for a glutamatergic phenotype. Both VGLUTs are different from the plasma membrane transporters in that they are driven by a proton electrochemical gradient across the vesicle membrane.
VGLUT 1 and VGLUT 2 show complementary expression patterns. Together, they are currently the best markers for glutamatergic nerve terminals and glutamatergic synapses.