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Neuroligin 1 - 129 111

A postsynaptic cell adhesion molecule localized to postsynaptic densities
Monoclonal mouse purified IgG
Cat. No.: 129 111
Amount: 100 µg
Price: $415.00
Cat. No. 129 111 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: not recommended
IHC: not recommended
IHC-P/FFPE: not tested yet
Clone 4C12
Subtype IgG1 (κ light chain)
Immunogen Recombinant protein corresponding to AA 1 to 695 from rat Neuroligin1 (UniProt Id: Q62765)
Epitop Epitop: AA 1 to 695 from rat Neuroligin1 (UniProt Id: Q62765)
Reactivity Reacts with: rat (Q62765), mouse (Q99K10).
Other species not tested yet.
Specificity Epitope present in all 4 isoforms of neuroligin 1; no cross reactivity to neuroligins 2, 3, 4. K.O. PubMed: 31801062
Data sheet 129_111.pdf

References for Neuroligin 1 - 129 111

Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers.
Camporesi E, Lashley T, Gobom J, Lantero-Rodriguez J, Hansson O, Zetterberg H, Blennow K, Becker B
Acta neuropathologica communications (2021) 91: 19. 129 111 WB; tested species: human
SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.
Gan KJ, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4042: 8088-8102. 129 111 WB; KO verified; tested species: mouse
Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations.
Xu ZX, Kim GH, Tan JW, Riso AE, Sun Y, Xu EY, Liao GY, Xu H, Lee SH, Do NY, Lee CH, et al.
Nature communications (2020) 111: 1797. 129 111 WB; tested species: mouse
Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.
Paskus JD, Tian C, Fingleton E, Shen C, Chen X, Li Y, Myers SA, Badger JD, Bemben MA, Herring BE, Roche KW, et al.
Cell reports (2019) 2910: 2944-2952.e5. 129 111 WB; KO verified; tested species: rat
Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters.
Trotter JH, Hao J, Maxeiner S, Tsetsenis T, Liu Z, Zhuang X, Südhof TC
The Journal of cell biology (2019) : . 129 111 WB; tested species: mouse
The STEP61 interactome reveals subunit-specific AMPA receptor binding and synaptic regulation.
Won S, Incontro S, Li Y, Nicoll RA, Roche KW
Proceedings of the National Academy of Sciences of the United States of America (2019) : . 129 111 WB; tested species: mouse
UPR activation specifically modulates glutamate neurotransmission in the cerebellum of a mouse model of autism.
Trobiani L, Favaloro FL, Di Castro MA, Di Mattia M, Cariello M, Miranda E, Canterini S, De Stefano ME, Comoletti D, Limatola C, De Jaco A, et al.
Neurobiology of disease (2018) : . 129 111 WB; tested species: mouse
The Adhesion-GPCR BAI1 Promotes Excitatory Synaptogenesis by Coordinating Bidirectional Trans-synaptic Signaling.
Tu YK, Duman JG, Tolias KF
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3839: 8388-8406. 129 111 WB, ICC; KD verified; tested species: human,cos cells
Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations.
Prada I, Gabrielli M, Turola E, Iorio A, D'Arrigo G, Parolisi R, De Luca M, Pacifici M, Bastoni M, Lombardi M, Legname G, et al.
Acta neuropathologica (2018) 1354: 529-550. 129 111 WB; tested species: mouse
Isoform-specific cleavage of neuroligin-3 reduces synapse strength.
Bemben MA, Nguyen TA, Li Y, Wang T, Nicoll RA, Roche KW
Molecular psychiatry (2018) : . 129 111 WB; tested species: rat
Neuroligin 1, 2, and 3 Regulation at the Synapse: FMRP-Dependent Translation and Activity-Induced Proteolytic Cleavage.
Chmielewska JJ, Kuzniewska B, Milek J, Urbanska K, Dziembowska M
Molecular neurobiology (2018) : . 129 111 WB; tested species: mouse
Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties.
Chanda S, Hale WD, Zhang B, Wernig M, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3729: 6816-6836. 129 111 WB; tested species: mouse
Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development.
Li J, Han W, Pelkey KA, Duan J, Mao X, Wang YX, Craig MT, Dong L, Petralia RS, McBain CJ, Lu W, et al.
Neuron (2017) 964: 808-826.e8. 129 111 WB; tested species: mouse
Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand.
Sterky FH, Trotter JH, Lee SJ, Recktenwald CV, Du X, Zhou B, Zhou P, Schwenk J, Fakler B, Südhof TC
Proceedings of the National Academy of Sciences of the United States of America (2017) 1147: E1253-E1262. 129 111 WB
Soluble Ectodomain of Neuroligin 1 Decreases Synaptic Activity by Activating Metabotropic Glutamate Receptor 2.
Gjørlund MD, Carlsen EMM, Kønig AB, Dmytrieva O, Petersen AV, Jacobsen J, Berezin V, Perrier JF, Owczarek S
Frontiers in molecular neuroscience (2017) 10: 116. 129 111 WB; tested species: mouse
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation.
Burré J, Sharma M, Südhof TC
Proceedings of the National Academy of Sciences of the United States of America (2014) 11140: E4274-83. 129 111 WB
CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.
Bemben MA, Shipman SL, Hirai T, Herring BE, Li Y, Badger JD, Nicoll RA, Diamond JS, Roche KW
Nature neuroscience (2014) 171: 56-64. 129 111 WB; tested species: rat
Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting.
Biesemann C, Grønborg M, Luquet E, Wichert SP, Bernard V, Bungers SR, Cooper B, Varoqueaux F, Li L, Byrne JA, Urlaub H, et al.
The EMBO journal (2014) 332: 157-70. 129 111 WB; tested species: mouse
Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes.
Jovičić A, Roshan R, Moisoi N, Pradervand S, Moser R, Pillai B, Luthi-Carter R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3312: 5127-37. 129 111 WB; tested species: rat
Neuroligin1 drives synaptic and behavioral maturation through intracellular interactions.
Hoy JL, Haeger PA, Constable JR, Arias RJ, McCallum R, Kyweriga M, Davis L, Schnell E, Wehr M, Castillo PE, Washbourne P, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3322: 9364-84. 129 111 WB; tested species: mouse
Membrane-tethered monomeric neurexin LNS-domain triggers synapse formation.
Gokce O, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3336: 14617-28. 129 111 WB; tested species: mouse
Neuroligin 1 is dynamically exchanged at postsynaptic sites.
Schapitz IU, Behrend B, Pechmann Y, Lappe-Siefke C, Kneussel SJ, Wallace KE, Stempel AV, Buck F, Grant SG, Schweizer M, Schmitz D, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3038: 12733-44. 129 111 WB, IP; tested species: rat
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Tabuchi K, Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC
Science (New York, N.Y.) (2007) 3185847: 71-6. 129 111 WB; tested species: mouse
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism.
Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, Südhof TC
The Journal of biological chemistry (2005) 28023: 22365-74. 129 111 WB, ICC
Downregulation of neuroligin1 ameliorates postoperative pain through inhibiting neuroligin1/postsynaptic density 95-mediated synaptic targeting of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor GluA1 subunits in rat dorsal horns.
Guo R, Li H, Li X, Xue Z, Sun Y, Ma D, Guan Y, Li J, Tian M, Wang Y
Molecular pain () 14: 1744806918766745. 129 111 WB; KD verified; tested species: rat
Neuroligin 1 is dynamically exchanged at postsynaptic sites.
Schapitz IU, Behrend B, Pechmann Y, Lappe-Siefke C, Kneussel SJ, Wallace KE, Stempel AV, Buck F, Grant SG, Schweizer M, Schmitz D, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3038: 12733-44. 129 111 WB, IP; tested species: rat
The Adhesion-GPCR BAI1 Promotes Excitatory Synaptogenesis by Coordinating Bidirectional Trans-synaptic Signaling.
Tu YK, Duman JG, Tolias KF
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3839: 8388-8406. 129 111 WB, ICC; KD verified; tested species: human,cos cells
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism.
Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, Südhof TC
The Journal of biological chemistry (2005) 28023: 22365-74. 129 111 WB, ICC
A preformed complex of postsynaptic proteins is involved in excitatory synapse development.
Gerrow K, Romorini S, Nabi SM, Colicos MA, Sala C, El-Husseini A
Neuron (2006) 494: 547-62. 129 111
Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta.
Comoletti D, Flynn R, Jennings LL, Chubykin A, Matsumura T, Hasegawa H, Südhof TC, Taylor P
The Journal of biological chemistry (2003) 27850: 50497-505. 129 111
Cat. No.: 129 111
Quantity: 100 µg
Price: $415.00
Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers.
Camporesi E, Lashley T, Gobom J, Lantero-Rodriguez J, Hansson O, Zetterberg H, Blennow K, Becker B
Acta neuropathologica communications (2021) 91: 19. 129 111 WB; tested species: human
SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.
Gan KJ, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4042: 8088-8102. 129 111 WB; KO verified; tested species: mouse
Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations.
Xu ZX, Kim GH, Tan JW, Riso AE, Sun Y, Xu EY, Liao GY, Xu H, Lee SH, Do NY, Lee CH, et al.
Nature communications (2020) 111: 1797. 129 111 WB; tested species: mouse
Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.
Paskus JD, Tian C, Fingleton E, Shen C, Chen X, Li Y, Myers SA, Badger JD, Bemben MA, Herring BE, Roche KW, et al.
Cell reports (2019) 2910: 2944-2952.e5. 129 111 WB; KO verified; tested species: rat
Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters.
Trotter JH, Hao J, Maxeiner S, Tsetsenis T, Liu Z, Zhuang X, Südhof TC
The Journal of cell biology (2019) : . 129 111 WB; tested species: mouse
The STEP61 interactome reveals subunit-specific AMPA receptor binding and synaptic regulation.
Won S, Incontro S, Li Y, Nicoll RA, Roche KW
Proceedings of the National Academy of Sciences of the United States of America (2019) : . 129 111 WB; tested species: mouse
UPR activation specifically modulates glutamate neurotransmission in the cerebellum of a mouse model of autism.
Trobiani L, Favaloro FL, Di Castro MA, Di Mattia M, Cariello M, Miranda E, Canterini S, De Stefano ME, Comoletti D, Limatola C, De Jaco A, et al.
Neurobiology of disease (2018) : . 129 111 WB; tested species: mouse
The Adhesion-GPCR BAI1 Promotes Excitatory Synaptogenesis by Coordinating Bidirectional Trans-synaptic Signaling.
Tu YK, Duman JG, Tolias KF
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3839: 8388-8406. 129 111 WB, ICC; KD verified; tested species: human,cos cells
Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations.
Prada I, Gabrielli M, Turola E, Iorio A, D'Arrigo G, Parolisi R, De Luca M, Pacifici M, Bastoni M, Lombardi M, Legname G, et al.
Acta neuropathologica (2018) 1354: 529-550. 129 111 WB; tested species: mouse
Isoform-specific cleavage of neuroligin-3 reduces synapse strength.
Bemben MA, Nguyen TA, Li Y, Wang T, Nicoll RA, Roche KW
Molecular psychiatry (2018) : . 129 111 WB; tested species: rat
Neuroligin 1, 2, and 3 Regulation at the Synapse: FMRP-Dependent Translation and Activity-Induced Proteolytic Cleavage.
Chmielewska JJ, Kuzniewska B, Milek J, Urbanska K, Dziembowska M
Molecular neurobiology (2018) : . 129 111 WB; tested species: mouse
Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties.
Chanda S, Hale WD, Zhang B, Wernig M, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3729: 6816-6836. 129 111 WB; tested species: mouse
Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development.
Li J, Han W, Pelkey KA, Duan J, Mao X, Wang YX, Craig MT, Dong L, Petralia RS, McBain CJ, Lu W, et al.
Neuron (2017) 964: 808-826.e8. 129 111 WB; tested species: mouse
Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand.
Sterky FH, Trotter JH, Lee SJ, Recktenwald CV, Du X, Zhou B, Zhou P, Schwenk J, Fakler B, Südhof TC
Proceedings of the National Academy of Sciences of the United States of America (2017) 1147: E1253-E1262. 129 111 WB
Soluble Ectodomain of Neuroligin 1 Decreases Synaptic Activity by Activating Metabotropic Glutamate Receptor 2.
Gjørlund MD, Carlsen EMM, Kønig AB, Dmytrieva O, Petersen AV, Jacobsen J, Berezin V, Perrier JF, Owczarek S
Frontiers in molecular neuroscience (2017) 10: 116. 129 111 WB; tested species: mouse
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation.
Burré J, Sharma M, Südhof TC
Proceedings of the National Academy of Sciences of the United States of America (2014) 11140: E4274-83. 129 111 WB
CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.
Bemben MA, Shipman SL, Hirai T, Herring BE, Li Y, Badger JD, Nicoll RA, Diamond JS, Roche KW
Nature neuroscience (2014) 171: 56-64. 129 111 WB; tested species: rat
Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting.
Biesemann C, Grønborg M, Luquet E, Wichert SP, Bernard V, Bungers SR, Cooper B, Varoqueaux F, Li L, Byrne JA, Urlaub H, et al.
The EMBO journal (2014) 332: 157-70. 129 111 WB; tested species: mouse
Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes.
Jovičić A, Roshan R, Moisoi N, Pradervand S, Moser R, Pillai B, Luthi-Carter R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3312: 5127-37. 129 111 WB; tested species: rat
Neuroligin1 drives synaptic and behavioral maturation through intracellular interactions.
Hoy JL, Haeger PA, Constable JR, Arias RJ, McCallum R, Kyweriga M, Davis L, Schnell E, Wehr M, Castillo PE, Washbourne P, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3322: 9364-84. 129 111 WB; tested species: mouse
Membrane-tethered monomeric neurexin LNS-domain triggers synapse formation.
Gokce O, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3336: 14617-28. 129 111 WB; tested species: mouse
Neuroligin 1 is dynamically exchanged at postsynaptic sites.
Schapitz IU, Behrend B, Pechmann Y, Lappe-Siefke C, Kneussel SJ, Wallace KE, Stempel AV, Buck F, Grant SG, Schweizer M, Schmitz D, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3038: 12733-44. 129 111 WB, IP; tested species: rat
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Tabuchi K, Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC
Science (New York, N.Y.) (2007) 3185847: 71-6. 129 111 WB; tested species: mouse
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism.
Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, Südhof TC
The Journal of biological chemistry (2005) 28023: 22365-74. 129 111 WB, ICC
Downregulation of neuroligin1 ameliorates postoperative pain through inhibiting neuroligin1/postsynaptic density 95-mediated synaptic targeting of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor GluA1 subunits in rat dorsal horns.
Guo R, Li H, Li X, Xue Z, Sun Y, Ma D, Guan Y, Li J, Tian M, Wang Y
Molecular pain () 14: 1744806918766745. 129 111 WB; KD verified; tested species: rat
Neuroligin 1 is dynamically exchanged at postsynaptic sites.
Schapitz IU, Behrend B, Pechmann Y, Lappe-Siefke C, Kneussel SJ, Wallace KE, Stempel AV, Buck F, Grant SG, Schweizer M, Schmitz D, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3038: 12733-44. 129 111 WB, IP; tested species: rat
The Adhesion-GPCR BAI1 Promotes Excitatory Synaptogenesis by Coordinating Bidirectional Trans-synaptic Signaling.
Tu YK, Duman JG, Tolias KF
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3839: 8388-8406. 129 111 WB, ICC; KD verified; tested species: human,cos cells
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism.
Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, Südhof TC
The Journal of biological chemistry (2005) 28023: 22365-74. 129 111 WB, ICC
A preformed complex of postsynaptic proteins is involved in excitatory synapse development.
Gerrow K, Romorini S, Nabi SM, Colicos MA, Sala C, El-Husseini A
Neuron (2006) 494: 547-62. 129 111
Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta.
Comoletti D, Flynn R, Jennings LL, Chubykin A, Matsumura T, Hasegawa H, Südhof TC, Taylor P
The Journal of biological chemistry (2003) 27850: 50497-505. 129 111
Background

Neuroligins form a family of postsynaptic cell surface molecules that interact with β-neurexins. They are 110-120 kDa polypeptides with homology to acetylcholine esterase. Neuroligin 1 and neuroligin 3 are specifically localized to post-synaptic densities of excitatory synapses whereas neuroligin 2 is found exclusively on inhibitory synapses.
Mutations in neuroligin 3 and neuroligin 4 have been implicated with a rare, heritable form of autism.