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Neuroligin 1 cytoplasmic domain - 129 013

A postsynaptic cell adhesion molecule localized to postsynaptic densities
Polyclonal rabbit purified antibody
Cat. No.: 129 013
Amount: 50 µg
Price: $370.00
Cat. No. 129 013 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: not tested yet
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 737 to 754 from rat Neuroligin1 (UniProt Id: Q62765)
Reactivity Reacts with: rat (Q62765), mouse (Q99K10).
Other species not tested yet.
Specificity Specific for neuroligin 1, no cross reactivity to neuroligins 2, 3, 4. K.O.
Data sheet 129_013.pdf

References for Neuroligin 1 - 129 013

A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency.
Mastro TL, Preza A, Basu S, Chattarji S, Till SM, Kind PC, Kennedy MB
eLife (2020) 9: . 129 013 WB; tested species: rat
Prefrontal Nectin3 Reduction Mediates Adolescent Stress-Induced Deficits of Social Memory, Spatial Working Memory, and Dendritic Structure in Mice.
Wang HL, Li JT, Wang H, Sun YX, Liu R, Wang XD, Su YA, Si TM
Neuroscience bulletin (2020) : . 129 013 WB; tested species: mouse
Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation.
Letellier M, Lagardère M, Tessier B, Janovjak H, Thoumine O
eLife (2020) 9: . 129 013 WB, IP; tested species: mouse
TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering.
Moretto E, Longatti A, Murru L, Chamma I, Sessa A, Zapata J, Hosy E, Sainlos M, Saint-Pol J, Rubinstein E, Choquet D, et al.
Cell reports (2019) 295: 1130-1146.e8. 129 013 WB; tested species: mouse
Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization.
Liu A, Zhou Z, Dang R, Zhu Y, Qi J, He G, Leung C, Pak D, Jia Z, Xie W
The Journal of cell biology (2016) 2124: 449-63. 129 013 WB; tested species: mouse
Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation.
Calafate S, Buist A, Miskiewicz K, Vijayan V, Daneels G, de Strooper B, de Wit J, Verstreken P, Moechars D
Cell reports (2015) 118: 1176-83. 129 013 WB; KD verified; tested species: rat
Promoter-like sequences regulating transcriptional activity in neurexin and neuroligin genes.
Runkel F, Rohlmann A, Reissner C, Brand SM, Missler M
Journal of neurochemistry (2013) 1271: 36-47. 129 013 WB
Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation.
Letellier M, Lagardère M, Tessier B, Janovjak H, Thoumine O
eLife (2020) 9: . 129 013 WB, IP; tested species: mouse
Cat. No.: 129 013
Quantity: 50 µg
Price: $370.00
A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency.
Mastro TL, Preza A, Basu S, Chattarji S, Till SM, Kind PC, Kennedy MB
eLife (2020) 9: . 129 013 WB; tested species: rat
Prefrontal Nectin3 Reduction Mediates Adolescent Stress-Induced Deficits of Social Memory, Spatial Working Memory, and Dendritic Structure in Mice.
Wang HL, Li JT, Wang H, Sun YX, Liu R, Wang XD, Su YA, Si TM
Neuroscience bulletin (2020) : . 129 013 WB; tested species: mouse
Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation.
Letellier M, Lagardère M, Tessier B, Janovjak H, Thoumine O
eLife (2020) 9: . 129 013 WB, IP; tested species: mouse
TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering.
Moretto E, Longatti A, Murru L, Chamma I, Sessa A, Zapata J, Hosy E, Sainlos M, Saint-Pol J, Rubinstein E, Choquet D, et al.
Cell reports (2019) 295: 1130-1146.e8. 129 013 WB; tested species: mouse
Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization.
Liu A, Zhou Z, Dang R, Zhu Y, Qi J, He G, Leung C, Pak D, Jia Z, Xie W
The Journal of cell biology (2016) 2124: 449-63. 129 013 WB; tested species: mouse
Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation.
Calafate S, Buist A, Miskiewicz K, Vijayan V, Daneels G, de Strooper B, de Wit J, Verstreken P, Moechars D
Cell reports (2015) 118: 1176-83. 129 013 WB; KD verified; tested species: rat
Promoter-like sequences regulating transcriptional activity in neurexin and neuroligin genes.
Runkel F, Rohlmann A, Reissner C, Brand SM, Missler M
Journal of neurochemistry (2013) 1271: 36-47. 129 013 WB
Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation.
Letellier M, Lagardère M, Tessier B, Janovjak H, Thoumine O
eLife (2020) 9: . 129 013 WB, IP; tested species: mouse
Background

Neuroligins form a family of postsynaptic cell surface molecules that interact with β-neurexins. They are 110-120 kDa polypeptides with homology to acetylcholine esterase. Neuroligin 1 and neuroligin 3 are specifically localized to post-synaptic densities of excitatory synapses whereas neuroligin 2 is found exclusively on inhibitory synapses.
Mutations in neuroligin 3 and neuroligin 4 have been implicated with a rare, heritable form of autism.