|Cat. No. 129 011||100 µg purified IgG, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.|
WB: 1 : 1000 (AP staining) gallery
ICC: not recommended
IHC: not recommended
IHC-P/FFPE: not tested yet
ELISA: yes (see remarks)
|Subtype||IgG2a (κ light chain)|
|Immunogen||Recombinant protein corresponding to AA 1 to 695 from rat Neuroligin1 (UniProt Id: Q62765)|
Epitop: AA 1 to 695 from rat Neuroligin1 (UniProt Id: Q62765)
Reacts with: rat (Q62765, Q62888, Q62889, ), mouse (Q99K10, Q69ZK9, Q8BYM5, B0F2B4).
Other species not tested yet.
|Specificity||Recognizes rat and mouse neuroligins 1-3 and mouse neuroligin 4. K.O.|
Neuroligins form a family of postsynaptic cell surface molecules that interact with β-neurexins. They are 110-120 kDa polypeptides with homology to acetylcholine esterase. Neuroligin 1 and neuroligin 3 are specifically localized to post-synaptic densities of excitatory synapses whereas neuroligin 2 is found exclusively on inhibitory synapses.
Mutations in neuroligin 3 and neuroligin 4 have been implicated with a rare, heritable form of autism.