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Neuroligin 1/2/3/4 - 129 011

A postsynaptic cell adhesion molecule localized to postsynaptic densities
Monoclonal mouse purified IgG
Cat. No.: 129 011
Amount: 100 µg
Price: $415.00
Cat. No. 129 011 100 µg purified IgG, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: not recommended
IHC: not recommended
IHC-P/FFPE: not tested yet
ELISA: yes (see remarks)
Clone 4F9
Subtype IgG2a (κ light chain)
Immunogen Recombinant protein corresponding to AA 1 to 695 from rat Neuroligin1 (UniProt Id: Q62765)
Epitop Epitop: AA 1 to 695 from rat Neuroligin1 (UniProt Id: Q62765)
Reactivity Reacts with: rat (Q62765, Q62888, Q62889, ), mouse (Q99K10, Q69ZK9, Q8BYM5, B0F2B4).
Other species not tested yet.
Specificity Recognizes rat and mouse neuroligins 1-3 and mouse neuroligin 4. K.O.
Remarks

ELISA: Suitable as capture antibody for sandwich-ELISA with cat. no. 129 103 or 129 203 as detector antibody. The ELISA-protocol for membrane proteins is recommended.

Data sheet 129_011.pdf

References for Neuroligin 1/2/3/4 - 129 011

Truncated tau deregulates synaptic markers in rat model for human tauopathy.
Jadhav S, Katina S, Kovac A, Kazmerova Z, Novak M, Zilka N
Frontiers in cellular neuroscience (2015) 9: 24. 129 011 WB
The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis.
Fujita-Jimbo E, Tanabe Y, Yu Z, Kojima K, Mori M, Li H, Iwamoto S, Yamagata T, Momoi MY, Momoi T
Molecular autism (2015) 6: 17. 129 011 WB
Neuroligin 1 is dynamically exchanged at postsynaptic sites.
Schapitz IU, Behrend B, Pechmann Y, Lappe-Siefke C, Kneussel SJ, Wallace KE, Stempel AV, Buck F, Grant SG, Schweizer M, Schmitz D, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3038: 12733-44. 129 011 WB; tested species: rat
The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.
Bottos A, Destro E, Rissone A, Graziano S, Cordara G, Assenzio B, Cera MR, Mascia L, Bussolino F, Arese M
Proceedings of the National Academy of Sciences of the United States of America (2009) 10649: 20782-7. 129 011 WB, IP, IHC; tested species: chicken
Postsynaptic neuroligin enhances presynaptic inputs at neuronal nicotinic synapses.
Conroy WG, Nai Q, Ross B, Naughton G, Berg DK
Developmental biology (2007) 3071: 79-91. 129 011 WB
A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family.
De Jaco A, Comoletti D, Kovarik Z, Gaietta G, Radic Z, Lockridge O, Ellisman MH, Taylor P
The Journal of biological chemistry (2006) 28114: 9667-76. 129 011 WB
Control of excitatory and inhibitory synapse formation by neuroligins.
Chih B, Engelman H, Scheiffele P
Science (New York, N.Y.) (2005) 3075713: 1324-8. 129 011 WB
The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.
Bottos A, Destro E, Rissone A, Graziano S, Cordara G, Assenzio B, Cera MR, Mascia L, Bussolino F, Arese M
Proceedings of the National Academy of Sciences of the United States of America (2009) 10649: 20782-7. 129 011 WB, IP, IHC; tested species: chicken
The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.
Bottos A, Destro E, Rissone A, Graziano S, Cordara G, Assenzio B, Cera MR, Mascia L, Bussolino F, Arese M
Proceedings of the National Academy of Sciences of the United States of America (2009) 10649: 20782-7. 129 011 WB, IP, IHC; tested species: chicken
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 129 011 ELISA
Cat. No.: 129 011
Quantity: 100 µg
Price: $415.00
Truncated tau deregulates synaptic markers in rat model for human tauopathy.
Jadhav S, Katina S, Kovac A, Kazmerova Z, Novak M, Zilka N
Frontiers in cellular neuroscience (2015) 9: 24. 129 011 WB
The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis.
Fujita-Jimbo E, Tanabe Y, Yu Z, Kojima K, Mori M, Li H, Iwamoto S, Yamagata T, Momoi MY, Momoi T
Molecular autism (2015) 6: 17. 129 011 WB
Neuroligin 1 is dynamically exchanged at postsynaptic sites.
Schapitz IU, Behrend B, Pechmann Y, Lappe-Siefke C, Kneussel SJ, Wallace KE, Stempel AV, Buck F, Grant SG, Schweizer M, Schmitz D, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3038: 12733-44. 129 011 WB; tested species: rat
The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.
Bottos A, Destro E, Rissone A, Graziano S, Cordara G, Assenzio B, Cera MR, Mascia L, Bussolino F, Arese M
Proceedings of the National Academy of Sciences of the United States of America (2009) 10649: 20782-7. 129 011 WB, IP, IHC; tested species: chicken
Postsynaptic neuroligin enhances presynaptic inputs at neuronal nicotinic synapses.
Conroy WG, Nai Q, Ross B, Naughton G, Berg DK
Developmental biology (2007) 3071: 79-91. 129 011 WB
A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family.
De Jaco A, Comoletti D, Kovarik Z, Gaietta G, Radic Z, Lockridge O, Ellisman MH, Taylor P
The Journal of biological chemistry (2006) 28114: 9667-76. 129 011 WB
Control of excitatory and inhibitory synapse formation by neuroligins.
Chih B, Engelman H, Scheiffele P
Science (New York, N.Y.) (2005) 3075713: 1324-8. 129 011 WB
The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.
Bottos A, Destro E, Rissone A, Graziano S, Cordara G, Assenzio B, Cera MR, Mascia L, Bussolino F, Arese M
Proceedings of the National Academy of Sciences of the United States of America (2009) 10649: 20782-7. 129 011 WB, IP, IHC; tested species: chicken
The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.
Bottos A, Destro E, Rissone A, Graziano S, Cordara G, Assenzio B, Cera MR, Mascia L, Bussolino F, Arese M
Proceedings of the National Academy of Sciences of the United States of America (2009) 10649: 20782-7. 129 011 WB, IP, IHC; tested species: chicken
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 129 011 ELISA
Background

Neuroligins form a family of postsynaptic cell surface molecules that interact with β-neurexins. They are 110-120 kDa polypeptides with homology to acetylcholine esterase. Neuroligin 1 and neuroligin 3 are specifically localized to post-synaptic densities of excitatory synapses whereas neuroligin 2 is found exclusively on inhibitory synapses.
Mutations in neuroligin 3 and neuroligin 4 have been implicated with a rare, heritable form of autism.