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alpha/beta Synuclein - 128 111

A protein involved in Parkinson's and Alzheimer's Disease
Monoclonal mouse purified IgG
Cat. No.: 128 111
Amount: 100 µg
Price: $415.00
Cat. No. 128 111 100 µg purified IgG, lyophilized. Azide was added before lyophilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: not recommended
IP: yes (see remarks)
ICC: 1 : 500 gallery  
IHC: 1 : 200 up to 1 : 500 gallery  
IHC-P/FFPE: 1 : 500 gallery  
Clone 56F2
Subtype IgG2a (κ light chain)
Immunogen Recombinant protein corresponding to AA 1 to 140 from human α-Synuclein (UniProt Id: P37840)
Reactivity Reacts with: human (P37840, Q16143), rat (P37377, Q63754), mouse (O55042, Q91ZZ3).
Other species not tested yet.
Specificity Recognizes α- and β-synuclein.
Remarks

IP: Precipitates mainly β-synuclein.

Data sheet 128_111.pdf

References for alpha/beta Synuclein - 128 111

Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.
Sambri I, D'Alessio R, Ezhova Y, Giuliano T, Sorrentino NC, Cacace V, De Risi M, Cataldi M, Annunziato L, De Leonibus E, Fraldi A, et al.
EMBO molecular medicine (2017) 91: 112-132. 128 111 ICC; tested species: mouse
Cat. No.: 128 111
Quantity: 100 µg
Price: $415.00
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.
Sambri I, D'Alessio R, Ezhova Y, Giuliano T, Sorrentino NC, Cacace V, De Risi M, Cataldi M, Annunziato L, De Leonibus E, Fraldi A, et al.
EMBO molecular medicine (2017) 91: 112-132. 128 111 ICC; tested species: mouse
Background
Synuclein proteins are produced by three genes. They share structural resemblance to apolipoproteins, but are abundant in the neuronal cytosol and present in enriched amounts at presynaptic terminals.
Synucleins have been specifically implicated in three diseases: Alzheimer's (AD), Parkinson's (PD) and breast cancer. In AD, a peptide derived from α-synuclein forms an intrinsic component of plaque amyloid. In PD, an α-synuclein allele is genetically linked to several independent familial cases, and the protein appears to accumulate in Lewy bodies. In breast cancer, increased expression of γ-synuclein correlates with disease progression.
In songbirds, α-synuclein expression is correlated with plasticity in the developing song control system. Although the normal function of synucleins is unknown, a role in synaptic plasticity seems likely.