Tailor-made Antibodies
and Tools for Life Science
quick order | cart
?
|
login
Home|||||Technical Support
Home > Products > 124 202

SAP102 antibody - 124 202 K.O.

SAP102 is a component of postsynaptic densities
Rabbit polyclonal antiserum
Cat. No.: 124 202
Amount: 200 µl
Price: $355.00
Cat. No. 124 202 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: not recommended (see remarks)
IHC: not recommended
IHC-P: not tested yet

Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section.

Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.

Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.

Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.

Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.
Immunogen Synthetic peptide corresponding to AA 14 to 26 from rat SAP102 (UniProt Id: Q62936)
Reactivity Reacts with: human (Q92796), rat (Q62936), mouse (P70175), hamster.
No signal: zebrafish.
Other species not tested yet.
Specificity K.O. validated
Matching control protein/peptide 124-2P
Remarks

ICC: Cat. no. 124 213 is recommended.
Data sheet 124_202.pdf

References for SAP102 - 124 202

Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor.
Bach A, Clausen BH, Kristensen LK, Andersen MG, Ellman DG, Hansen PBL, Hasseldam H, Heitz M, Özcelik D, Tuck EJ, Kopanitsa MV, et al.
Neuropharmacology (2019) : . 124 202 WB; tested species: mouse
Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis.
Smalla KH, Sahin J, Putzke J, Tischmeyer W, Gundelfinger ED, Kreutz MR
Neurochemical research (2009) 348: 1405-9. 124 202 WB
Synaptic Ras GTPase activating protein regulates pattern formation in the trigeminal system of mice.
Barnett MW, Watson RF, Vitalis T, Porter K, Komiyama NH, Stoney PN, Gillingwater TH, Grant SG, Kind PC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 265: 1355-65. 124 202 WB
Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia.
Kristiansen LV, Beneyto M, Haroutunian V, Meador-Woodruff JH
Molecular psychiatry (2006) 118: 737-47, 705. 124 202 WB
Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 124 202 WB
A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation.
Ludford-Menting MJ, Oliaro J, Sacirbegovic F, Cheah ET, Pedersen N, Thomas SJ, Pasam A, Iazzolino R, Dow LE, Waterhouse NJ, Murphy A, et al.
Immunity (2005) 226: 737-48. 124 202 WB, ICC
Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.
Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2005) 956: 1732-45. 124 202 WB
Chaperone-mediated autophagy in neuronal dendrites utilizes activity-dependent lysosomal exocytosis for protein disposal.
Grochowska KM, Sperveslage M, Raman R, Failla AV, Głów D, Schulze C, Laprell L, Fehse B, Kreutz MR
Cell reports (2023) 428: 112998. 124 202 ICC; tested species: mouse,rat
A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation.
Ludford-Menting MJ, Oliaro J, Sacirbegovic F, Cheah ET, Pedersen N, Thomas SJ, Pasam A, Iazzolino R, Dow LE, Waterhouse NJ, Murphy A, et al.
Immunity (2005) 226: 737-48. 124 202 WB, ICC
Cat. No.: 124 202
Amount: 200 µl
Price: $355.00
Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor.
Bach A, Clausen BH, Kristensen LK, Andersen MG, Ellman DG, Hansen PBL, Hasseldam H, Heitz M, Özcelik D, Tuck EJ, Kopanitsa MV, et al.
Neuropharmacology (2019) : . 124 202 WB; tested species: mouse
Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis.
Smalla KH, Sahin J, Putzke J, Tischmeyer W, Gundelfinger ED, Kreutz MR
Neurochemical research (2009) 348: 1405-9. 124 202 WB
Synaptic Ras GTPase activating protein regulates pattern formation in the trigeminal system of mice.
Barnett MW, Watson RF, Vitalis T, Porter K, Komiyama NH, Stoney PN, Gillingwater TH, Grant SG, Kind PC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 265: 1355-65. 124 202 WB
Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia.
Kristiansen LV, Beneyto M, Haroutunian V, Meador-Woodruff JH
Molecular psychiatry (2006) 118: 737-47, 705. 124 202 WB
Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 124 202 WB
A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation.
Ludford-Menting MJ, Oliaro J, Sacirbegovic F, Cheah ET, Pedersen N, Thomas SJ, Pasam A, Iazzolino R, Dow LE, Waterhouse NJ, Murphy A, et al.
Immunity (2005) 226: 737-48. 124 202 WB, ICC
Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.
Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2005) 956: 1732-45. 124 202 WB
Chaperone-mediated autophagy in neuronal dendrites utilizes activity-dependent lysosomal exocytosis for protein disposal.
Grochowska KM, Sperveslage M, Raman R, Failla AV, Głów D, Schulze C, Laprell L, Fehse B, Kreutz MR
Cell reports (2023) 428: 112998. 124 202 ICC; tested species: mouse,rat
A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation.
Ludford-Menting MJ, Oliaro J, Sacirbegovic F, Cheah ET, Pedersen N, Thomas SJ, Pasam A, Iazzolino R, Dow LE, Waterhouse NJ, Murphy A, et al.
Immunity (2005) 226: 737-48. 124 202 WB, ICC
WB
Background

SAP 102 (synapse associated protein of 102 kDa, also called DLG 3) belongs to the PSD 95 family containing a modular structure with three PDZ-, one SH3- and a guanylate kinase-like domain. It is a component of postsynaptic densities in central synapses. It is involved in NMDA receptor clustering and immobilization. In vitro, all three PDZ domains in SAP 102 bind the cytoplasmic tail of NR2B.
Other products for this target