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Home > Products > 122 402

Complexin4 antibody - 122 402 K.O.

Complexin4 is a nerve-terminal syntaxin binding protein in retinal ribbon synapses
Rabbit polyclonal antiserum
Cat. No.: 122 402
Amount: 200 µl
Price: $360.00
Cat. No. 122 402 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: not tested yet
IHC: 1 : 4000 up to 1 : 40000 (see remarks) gallery  
IHC-P: 1 : 200 gallery  
Immunogen Recombinant protein corresponding to AA 1 to 160 from mouse Complexin4 (UniProt Id: Q80WM3)
Reactivity Reacts with: rat (D3ZM85), mouse (Q80WM3).
Other species not tested yet.
Specificity Specific for complexin 4, no cross reaction to other complexins. K.O. validated PubMed: 19386896
Remarks

IHC: For optimal results, mild fixation (immersion fixation with 4% PFA for 15 min) according to Gierke et al. 2023 is recommended.
Data sheet 122_402.pdf

References for Complexin4 - 122 402

Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse.
Chang S, Reim K, Pedersen M, Neher E, Brose N, Taschenberger H
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3521: 8272-90. 122 402 WB
Enrichment and differential targeting of complexins 3 and 4 in ribbon-containing sensory neurons during zebrafish development.
Zanazzi G, Matthews G
Neural development (2010) 5: 24. 122 402 IHC, WB, ICC; tested species: zebrafish
Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4.
Reim K, Regus-Leidig H, Ammermüller J, El-Kordi A, Radyushkin K, Ehrenreich H, Brandstätter JH, Brose N
Journal of cell science (2009) 122Pt 9: 1352-61. 122 402 WB, IHC; KO verified; tested species: mouse
Structurally and functionally unique complexins at retinal ribbon synapses.
Reim K, Wegmeyer H, Brandstätter JH, Xue M, Rosenmund C, Dresbach T, Hofmann K, Brose N
The Journal of cell biology (2005) 1694: 669-80. 122 402 WB, IHC
Promiscuous interaction of SNAP-25 with all plasma membrane syntaxins in a neuroendocrine cell.
Bajohrs M, Darios F, Peak-Chew SY, Davletov B
The Biochemical journal (2005) 392Pt 2: 283-9. 122 402 WB
Cat. No.: 122 402
Amount: 200 µl
Price: $360.00
WB
IHC
IHC-P
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