Cat. No.: 116 203
Amount: 50 µg
Price:
$455.00
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| Cat. No. 116 203 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: not tested yet ICC: not tested yet IHC: not tested yet IHC-P: not tested yet |
| Immunogen | Synthetic peptide corresponding to AA 575 to 593 from rat Munc18-3 (UniProt Id: Q99PV2) |
| Reactivity |
Reacts with: rat (Q99PV2). No signal: zebrafish. Other species not tested yet. |
| Specificity | Specific for Munc 18-3, no cross-reactivity to Munc 18-1 and Munc 18-2. |
| Matching control protein/peptide | 116-2P |
| Data sheet | 116_203.pdf |
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Munc 18 is an abundant neuronal protein that tightly binds to the synaptic fusion protein syntaxin 1. It is highly homologous to the C. elegans unc-18 gene product, and weakly related to the yeast sec1, sly1, and slp1 genes.
There are three munc 18 isoforms in mammals. Munc 18-1 or 18a, also referred to as rb-sec1, n-sec1, stxbp1 and p67, is primarily expressed in neurons. Munc 18-2 or 18b, also referred to as stxbp2, and Munc 18-3 or 18c are expressed ubiquitously.