GABAergic/Glycinergic and Glutamatergic Neurons Mediate Distinct Neurodevelopmental Phenotypes of STXBP1 Encephalopathy.Kim JH, Chen W, Chao ES, Rivera A, Kaku HN, Jiang K, Lee D, Chen H, Vega JM, Chin TV, Jin K, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2024) 4414: .
116 002 WB; tested species: mouse Reduced synaptic depression in human neurons carrying homozygous disease-causing STXBP1 variant L446F.Öttl M, Toonen RF, Verhage M
Human molecular genetics (2024) : .
116 002 WB; tested species: stem cells A synthetic organelle approach to probe SNARE-mediated membrane fusion in a bacterial host.Ferreras S, Singh NP, Le Borgne R, Bun P, Binz T, Parton RG, Verbavatz JM, Vannier C, Galli T
The Journal of biological chemistry (2023) 2993: 102974.
116 002 WB; tested species: mouse A novel synaptopathy-defective synaptic vesicle protein trafficking in the mutant CHMP2B mouse model of frontotemporal dementia.Clayton EL, Bonnycastle K, Isaacs AM, Cousin MA, Schorge S
Journal of neurochemistry (2022) 1603: 412-425.
116 002 WB; tested species: mouse MAFA and MAFB regulate exocytosis-related genes in human β-cells.Cataldo LR, Singh T, Achanta K, Bsharat S, Prasad RB, Luan C, Renström E, Eliasson L, Artner I
Acta physiologica (Oxford, England) (2022) 2342: e13761.
116 002 WB, IHC; tested species: mouse Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy.Chen W, Cai ZL, Chao ES, Chen H, Longley CM, Hao S, Chao HT, Kim JH, Messier JE, Zoghbi HY, Tang J, et al.
eLife (2020) 9: .
116 002 WB; KO verified; tested species: mouse Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells.Nagao M, Esguerra JLS, Asai A, Ofori JK, Edlund A, Wendt A, Sugihara H, Wollheim CB, Oikawa S, Eliasson L
Diabetes (2020) 696: 1193-1205.
116 002 WB; tested species: human Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin.Gowrisankaran S, Houy S, Del Castillo JGP, Steubler V, Gelker M, Kroll J, Pinheiro PS, Schwitters D, Halbsgut N, Pechstein A, van Weering JRT, et al.
Nature communications (2020) 111: 1266.
116 002 WB, ICC; tested species: mouse Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition.Davenport EC, Szulc BR, Drew J, Taylor J, Morgan T, Higgs NF, López-Doménech G, Kittler JT
Cell reports (2019) 268: 2037-2051.e6.
116 002 WB, ICC; tested species: mouse Tuning of glutamate, but not GABA, release by an intra-synaptic vesicles APP domain whose function can be modulated by β- or α-secretase cleavage.Yao W, Tambini MD, Liu X, D'Adamio L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : .
116 002 WB; tested species: mouse Merlin modulates process outgrowth and synaptogenesis in the cerebellum.Toledo A, Lang F, Doengi M, Morrison H, Stein V, Baader SL
Brain structure & function (2019) : .
116 002 WB; tested species: mouse Overexpression of miR-1 in the heart attenuates hippocampal synaptic vesicle exocytosis by the posttranscriptional regulation of SNAP-25 through the transportation of exosomes.Duan MJ, Yan ML, Wang Q, Mao M, Su D, Sun LL, Li KX, Qu Y, Sun Q, Zhang XY, Huang SY, et al.
Cell communication and signaling : CCS (2018) 161: 91.
116 002 WB; tested species: mouse SNAP-25a and SNAP-25b differently mediate interactions with Munc18-1 and Gβγ subunits.Daraio T, Valladolid-Acebes I, Brismar K, Bark C
Neuroscience letters (2018) 674: 75-80.
116 002 WB; tested species: mouse MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles.Salunkhe VA, Ofori JK, Gandasi NR, Salö SA, Hansson S, Andersson ME, Wendt A, Barg S, Esguerra JLS, Eliasson L
Physiological reports (2017) 521: .
116 002 WB; tested species: rat Potentiation of excitatory synaptic transmission ameliorates aggression in mice with Stxbp1 haploinsufficiency.Miyamoto H, Shimohata A, Abe M, Abe T, Mazaki E, Amano K, Suzuki T, Tatsukawa T, Itohara S, Sakimura K, Yamakawa K, et al.
Human molecular genetics (2017) 2624: 4961-4974.
116 002 WB; tested species: mouse Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8.
116 002 WB Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.Spangler SA, Schmitz SK, Kevenaar JT, de Graaff E, de Wit H, Demmers J, Toonen RF, Hoogenraad CC
The Journal of cell biology (2013) 2016: 915-28.
116 002 WB, ICC mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.Wentzel C, Sommer JE, Nair R, Stiefvater A, Sibarita JB, Scheiffele P
Neuron (2013) 786: 1012-23.
116 002 WB; tested species: mouse Role for Reelin in neurotransmitter release.Hellwig S, Hack I, Kowalski J, Brunne B, Jarowyj J, Unger A, Bock HH, Junghans D, Frotscher M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 317: 2352-60.
116 002 WB Abrogating Munc18-1-SNARE complex interaction has limited impact on exocytosis in PC12 cells.Malintan NT, Nguyen TH, Han L, Latham CF, Osborne SL, Wen PJ, Lim SJ, Sugita S, Collins BM, Meunier FA
The Journal of biological chemistry (2009) 28432: 21637-46.
116 002 WB, ICC; tested species: rat Preferential increase in the hippocampal synaptic vesicle protein 2A (SV2A) by pentylenetetrazole kindling.Ohno Y, Ishihara S, Terada R, Kikuta M, Sofue N, Kawai Y, Serikawa T, Sasa M
Biochemical and biophysical research communications (2009) 3903: 415-20.
116 002 WB Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18.Camoletto PG, Vara H, Morando L, Connell E, Marletto FP, Giustetto M, Sassoè-Pognetto M, Van Veldhoven PP, Ledesma MD
PloS one (2009) 44: e5310.
116 002 WB Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.Olsen O, Moore KA, Fukata M, Kazuta T, Trinidad JC, Kauer FW, Streuli M, Misawa H, Burlingame AL, Nicoll RA, Bredt DS, et al.
The Journal of cell biology (2005) 1707: 1127-34.
116 002 WB Granuphilin molecularly docks insulin granules to the fusion machinery.Gomi H, Mizutani S, Kasai K, Itohara S, Izumi T
The Journal of cell biology (2005) 1711: 99-109.
116 002 WB Munc18-syntaxin complexes and exocytosis in human platelets.Houng A, Polgar J, Reed GL
The Journal of biological chemistry (2003) 27822: 19627-33.
116 002 WB 
