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SNAP23 antibody - 111 202 K.O.

SNAP23 is a palmitoylated plasma membrane protein; ubiquitously expressed isoform of SNAP 25
Rabbit polyclonal antiserum
Cat. No.: 111 202
Amount: 200 µl
Price: $355.00
Cat. No. 111 202 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes (see remarks)
ICC: 1 : 50
IHC: yes
IHC-P: yes
Immunogen Synthetic peptide corresponding to AA 196 to 211 from human SNAP23 (UniProt Id: O00161)
Reactivity Reacts with: human (O00161), rat (O70377), mouse (O09044), hamster, pig, zebrafish.
Other species not tested yet.
Specificity K.O. validated PubMed: 30573565
Matching control protein/peptide 111-2P
Remarks

IP: Cat. no. 111 213 is recommended
Data sheet 111_202.pdf

References for SNAP23 - 111 202

IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis.
Lu Z, Xiao S, Chen W, Zhu R, Yang H, Steinhoff M, Li Y, Cheng W, Yan X, Li L, Xue S, et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2022) 366: e22334. 111 202 WB; tested species: mouse
SNAP23 regulates KCC2 membrane insertion and activity following mZnR/GPR39 activation in hippocampalneurons.
Asraf H, Bogdanovic M, Gottesman N, Sekler I, Aizenman E, Hershfinkel M
iScience (2022) 252: 103751. 111 202 WB; tested species: mouse
Microglia modulate gliotransmission through the regulation of VAMP2 proteins in astrocytes.
Takata-Tsuji F, Chounlamountri N, Do LD, Philippot C, Novion Ducassou J, Couté Y, Ben Achour S, Honnorat J, Place C, Pascual O
Glia (2021) 691: 61-72. 111 202 WB; tested species: mouse
Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes.
Dolai S, Takahashi T, Qin T, Liang T, Xie L, Kang F, Miao YF, Xie H, Kang Y, Manuel J, Winter E, et al.
Autophagy (2020) : 1-14. 111 202 WB, ICC; KD verified; tested species: human
Cardiac SNARE Expression in Health and Disease.
Bowman PRT, Smith GL, Gould GW
Frontiers in endocrinology (2019) 10: 881. 111 202 WB; tested species: mouse
New Engineered-Botulinum Toxins Inhibit the Release of Pain-Related Mediators.
Tang M, Meng J, Wang J
International journal of molecular sciences (2019) 211: . 111 202 WB; tested species: mouse
Invasion by activated macrophages requires delivery of nascent MT1-MMP through late endosomes/lysosomes to the cell surface.
Röhl J, West ZE, Rudolph M, Zaharia A, Van Lonkhuyzen D, Hickey DK, Semmler ABT, Murray RZ
Traffic (Copenhagen, Denmark) (2019) : . 111 202 WB, ICC; tested species: mouse
Platelet-specific deletion of SNAP23 ablates granule secretion, substantially inhibiting arterial and venous thrombosis in mice.
Williams CM, Li Y, Brown E, Poole AW
Blood advances (2018) 224: 3627-3636. 111 202 WB; KO verified; tested species: mouse
Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.
Verweij FJ, Bebelman MP, Jimenez CR, Garcia-Vallejo JJ, Janssen H, Neefjes J, Knol JC, de Goeij-de Haas R, Piersma SR, Baglio SR, Verhage M, et al.
The Journal of cell biology (2018) : . 111 202 WB, ICC; KD verified; tested species: mouse
Oxidized phagosomal NOX2 complex is replenished from lysosomes.
Dingjan I, Linders PT, van den Bekerom L, Baranov MV, Halder P, Ter Beest M, van den Bogaart G
Journal of cell science (2017) 1307: 1285-1298. 111 202 WB, ICC; KD verified; tested species: human
Selected SNARE proteins are essential for the polarized membrane insertion of igf-1 receptor and the regulation of initial axonal outgrowth in neurons.
Grassi D, Plonka FB, Oksdath M, Guil AN, Sosa LJ, Quiroga S
Cell discovery (2015) 1: 15023. 111 202 WB, ICC
The SNARE protein vti1a functions in dense-core vesicle biogenesis.
Walter AM, Kurps J, de Wit H, Schöning S, Toft-Bertelsen TL, Lauks J, Ziomkiewicz I, Weiss AN, Schulz A, Fischer von Mollard G, Verhage M, et al.
The EMBO journal (2014) 3315: 1681-97. 111 202 WB; tested species: mouse
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 111 202 WB, ICC, IHC; tested species: mouse,rat
Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking.
Sadakata T, Sekine Y, Oka M, Itakura M, Takahashi M, Furuichi T
The FEBS journal (2012) 2793: 384-94. 111 202 WB; tested species: mouse
Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress.
Liu ST, Sharon-Friling R, Ivanova P, Milne SB, Myers DS, Rabinowitz JD, Brown HA, Shenk T
Proceedings of the National Academy of Sciences of the United States of America (2011) 10831: 12869-74. 111 202 WB; tested species: human
How pig sperm prepares to fertilize: stable acrosome docking to the plasma membrane.
Tsai PS, Garcia-Gil N, van Haeften T, Gadella BM
PloS one (2010) 56: e11204. 111 202 WB, IP; tested species: pig
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells.
Sander LE, Frank SP, Bolat S, Blank U, Galli T, Bigalke H, Bischoff SC, Lorentz A
European journal of immunology (2008) 383: 855-63. 111 202 WB, IP; tested species: human,rat
Phosphorylation of SNAP-23 in activated human platelets.
Polgár J, Lane WS, Chung SH, Houng AK, Reed GL
The Journal of biological chemistry (2003) 27845: 44369-76. 111 202 IP, WB; tested species: human
How pig sperm prepares to fertilize: stable acrosome docking to the plasma membrane.
Tsai PS, Garcia-Gil N, van Haeften T, Gadella BM
PloS one (2010) 56: e11204. 111 202 WB, IP; tested species: pig
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells.
Sander LE, Frank SP, Bolat S, Blank U, Galli T, Bigalke H, Bischoff SC, Lorentz A
European journal of immunology (2008) 383: 855-63. 111 202 WB, IP; tested species: human,rat
Phosphorylation of SNAP-23 in activated human platelets.
Polgár J, Lane WS, Chung SH, Houng AK, Reed GL
The Journal of biological chemistry (2003) 27845: 44369-76. 111 202 IP, WB; tested species: human
The endothelial diapedesis synapse regulates transcellular migration of human T lymphocytes in a CX3CL1- and SNAP23-dependent manner.
Schoppmeyer R, van Steen ACI, Kempers L, Timmerman AL, Nolte MA, Hombrink P, van Buul JD
Cell reports (2022) 383: 110243. 111 202 ICC; tested species: human
Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes.
Dolai S, Takahashi T, Qin T, Liang T, Xie L, Kang F, Miao YF, Xie H, Kang Y, Manuel J, Winter E, et al.
Autophagy (2020) : 1-14. 111 202 WB, ICC; KD verified; tested species: human
Invasion by activated macrophages requires delivery of nascent MT1-MMP through late endosomes/lysosomes to the cell surface.
Röhl J, West ZE, Rudolph M, Zaharia A, Van Lonkhuyzen D, Hickey DK, Semmler ABT, Murray RZ
Traffic (Copenhagen, Denmark) (2019) : . 111 202 WB, ICC; tested species: mouse
β1-integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells.
Birkner K, Wasser B, Ruck T, Thalman C, Luchtman D, Pape K, Schmaul S, Bitar L, Krämer-Albers EM, Stroh A, Meuth SG, et al.
The Journal of clinical investigation (2019) : . 111 202 ICC; tested species: mouse
Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.
Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D'Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, et al.
The EMBO journal (2018) 371: 139-159. 111 202 ICC; tested species: mouse
Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.
Verweij FJ, Bebelman MP, Jimenez CR, Garcia-Vallejo JJ, Janssen H, Neefjes J, Knol JC, de Goeij-de Haas R, Piersma SR, Baglio SR, Verhage M, et al.
The Journal of cell biology (2018) : . 111 202 WB, ICC; KD verified; tested species: mouse
Oxidized phagosomal NOX2 complex is replenished from lysosomes.
Dingjan I, Linders PT, van den Bekerom L, Baranov MV, Halder P, Ter Beest M, van den Bogaart G
Journal of cell science (2017) 1307: 1285-1298. 111 202 WB, ICC; KD verified; tested species: human
SNAP-25 gene family members differentially support secretory vesicle fusion.
Arora S, Saarloos I, Kooistra R, van de Bospoort R, Verhage M, Toonen RF
Journal of cell science (2017) 13011: 1877-1889. 111 202 ICC; tested species: mouse
Selected SNARE proteins are essential for the polarized membrane insertion of igf-1 receptor and the regulation of initial axonal outgrowth in neurons.
Grassi D, Plonka FB, Oksdath M, Guil AN, Sosa LJ, Quiroga S
Cell discovery (2015) 1: 15023. 111 202 WB, ICC
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 111 202 WB, ICC, IHC; tested species: mouse,rat
Temporal characteristics of vesicular fusion in astrocytes: examination of synaptobrevin 2-laden vesicles at single vesicle resolution.
Malarkey EB, Parpura V
The Journal of physiology (2011) 58917: 4271-300. 111 202 ICC; tested species: rat
Immunofluorescence microscopy of SNAP23 in human skeletal muscle reveals colocalization with plasma membrane, lipid droplets, and mitochondria.
Strauss JA, Shaw CS, Bradley H, Wilson OJ, Dorval T, Pilling J, Wagenmakers AJ
Physiological reports (2016) 41: . 111 202 IHC
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 111 202 WB, ICC, IHC; tested species: mouse,rat
Choroid plexus epithelial cells express the adhesion protein P-cadherin at cell-cell contacts and syntaxin-4 in the luminal membrane domain.
Christensen IB, Mogensen EN, Damkier HH, Praetorius J
American journal of physiology. Cell physiology (2018) 3145: C519-C533. 111 202 IHC-P; tested species: mouse
SNAP23 is selectively expressed in airway secretory cells and mediates baseline and stimulated mucin secretion.
Ren B, Azzegagh Z, Jaramillo AM, Zhu Y, Pardo-Saganta A, Bagirzadeh R, Flores JR, Han W, Tang YJ, Tu J, Alanis DM, et al.
Bioscience reports (2015) 353: . 111 202 IHC-P; tested species: mouse
Cat. No.: 111 202
Amount: 200 µl
Price: $355.00
IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis.
Lu Z, Xiao S, Chen W, Zhu R, Yang H, Steinhoff M, Li Y, Cheng W, Yan X, Li L, Xue S, et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2022) 366: e22334. 111 202 WB; tested species: mouse
SNAP23 regulates KCC2 membrane insertion and activity following mZnR/GPR39 activation in hippocampalneurons.
Asraf H, Bogdanovic M, Gottesman N, Sekler I, Aizenman E, Hershfinkel M
iScience (2022) 252: 103751. 111 202 WB; tested species: mouse
Microglia modulate gliotransmission through the regulation of VAMP2 proteins in astrocytes.
Takata-Tsuji F, Chounlamountri N, Do LD, Philippot C, Novion Ducassou J, Couté Y, Ben Achour S, Honnorat J, Place C, Pascual O
Glia (2021) 691: 61-72. 111 202 WB; tested species: mouse
Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes.
Dolai S, Takahashi T, Qin T, Liang T, Xie L, Kang F, Miao YF, Xie H, Kang Y, Manuel J, Winter E, et al.
Autophagy (2020) : 1-14. 111 202 WB, ICC; KD verified; tested species: human
Cardiac SNARE Expression in Health and Disease.
Bowman PRT, Smith GL, Gould GW
Frontiers in endocrinology (2019) 10: 881. 111 202 WB; tested species: mouse
New Engineered-Botulinum Toxins Inhibit the Release of Pain-Related Mediators.
Tang M, Meng J, Wang J
International journal of molecular sciences (2019) 211: . 111 202 WB; tested species: mouse
Invasion by activated macrophages requires delivery of nascent MT1-MMP through late endosomes/lysosomes to the cell surface.
Röhl J, West ZE, Rudolph M, Zaharia A, Van Lonkhuyzen D, Hickey DK, Semmler ABT, Murray RZ
Traffic (Copenhagen, Denmark) (2019) : . 111 202 WB, ICC; tested species: mouse
Platelet-specific deletion of SNAP23 ablates granule secretion, substantially inhibiting arterial and venous thrombosis in mice.
Williams CM, Li Y, Brown E, Poole AW
Blood advances (2018) 224: 3627-3636. 111 202 WB; KO verified; tested species: mouse
Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.
Verweij FJ, Bebelman MP, Jimenez CR, Garcia-Vallejo JJ, Janssen H, Neefjes J, Knol JC, de Goeij-de Haas R, Piersma SR, Baglio SR, Verhage M, et al.
The Journal of cell biology (2018) : . 111 202 WB, ICC; KD verified; tested species: mouse
Oxidized phagosomal NOX2 complex is replenished from lysosomes.
Dingjan I, Linders PT, van den Bekerom L, Baranov MV, Halder P, Ter Beest M, van den Bogaart G
Journal of cell science (2017) 1307: 1285-1298. 111 202 WB, ICC; KD verified; tested species: human
Selected SNARE proteins are essential for the polarized membrane insertion of igf-1 receptor and the regulation of initial axonal outgrowth in neurons.
Grassi D, Plonka FB, Oksdath M, Guil AN, Sosa LJ, Quiroga S
Cell discovery (2015) 1: 15023. 111 202 WB, ICC
The SNARE protein vti1a functions in dense-core vesicle biogenesis.
Walter AM, Kurps J, de Wit H, Schöning S, Toft-Bertelsen TL, Lauks J, Ziomkiewicz I, Weiss AN, Schulz A, Fischer von Mollard G, Verhage M, et al.
The EMBO journal (2014) 3315: 1681-97. 111 202 WB; tested species: mouse
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 111 202 WB, ICC, IHC; tested species: mouse,rat
Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking.
Sadakata T, Sekine Y, Oka M, Itakura M, Takahashi M, Furuichi T
The FEBS journal (2012) 2793: 384-94. 111 202 WB; tested species: mouse
Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress.
Liu ST, Sharon-Friling R, Ivanova P, Milne SB, Myers DS, Rabinowitz JD, Brown HA, Shenk T
Proceedings of the National Academy of Sciences of the United States of America (2011) 10831: 12869-74. 111 202 WB; tested species: human
How pig sperm prepares to fertilize: stable acrosome docking to the plasma membrane.
Tsai PS, Garcia-Gil N, van Haeften T, Gadella BM
PloS one (2010) 56: e11204. 111 202 WB, IP; tested species: pig
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells.
Sander LE, Frank SP, Bolat S, Blank U, Galli T, Bigalke H, Bischoff SC, Lorentz A
European journal of immunology (2008) 383: 855-63. 111 202 WB, IP; tested species: human,rat
Phosphorylation of SNAP-23 in activated human platelets.
Polgár J, Lane WS, Chung SH, Houng AK, Reed GL
The Journal of biological chemistry (2003) 27845: 44369-76. 111 202 IP, WB; tested species: human
How pig sperm prepares to fertilize: stable acrosome docking to the plasma membrane.
Tsai PS, Garcia-Gil N, van Haeften T, Gadella BM
PloS one (2010) 56: e11204. 111 202 WB, IP; tested species: pig
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells.
Sander LE, Frank SP, Bolat S, Blank U, Galli T, Bigalke H, Bischoff SC, Lorentz A
European journal of immunology (2008) 383: 855-63. 111 202 WB, IP; tested species: human,rat
Phosphorylation of SNAP-23 in activated human platelets.
Polgár J, Lane WS, Chung SH, Houng AK, Reed GL
The Journal of biological chemistry (2003) 27845: 44369-76. 111 202 IP, WB; tested species: human
The endothelial diapedesis synapse regulates transcellular migration of human T lymphocytes in a CX3CL1- and SNAP23-dependent manner.
Schoppmeyer R, van Steen ACI, Kempers L, Timmerman AL, Nolte MA, Hombrink P, van Buul JD
Cell reports (2022) 383: 110243. 111 202 ICC; tested species: human
Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes.
Dolai S, Takahashi T, Qin T, Liang T, Xie L, Kang F, Miao YF, Xie H, Kang Y, Manuel J, Winter E, et al.
Autophagy (2020) : 1-14. 111 202 WB, ICC; KD verified; tested species: human
Invasion by activated macrophages requires delivery of nascent MT1-MMP through late endosomes/lysosomes to the cell surface.
Röhl J, West ZE, Rudolph M, Zaharia A, Van Lonkhuyzen D, Hickey DK, Semmler ABT, Murray RZ
Traffic (Copenhagen, Denmark) (2019) : . 111 202 WB, ICC; tested species: mouse
β1-integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells.
Birkner K, Wasser B, Ruck T, Thalman C, Luchtman D, Pape K, Schmaul S, Bitar L, Krämer-Albers EM, Stroh A, Meuth SG, et al.
The Journal of clinical investigation (2019) : . 111 202 ICC; tested species: mouse
Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.
Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D'Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, et al.
The EMBO journal (2018) 371: 139-159. 111 202 ICC; tested species: mouse
Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.
Verweij FJ, Bebelman MP, Jimenez CR, Garcia-Vallejo JJ, Janssen H, Neefjes J, Knol JC, de Goeij-de Haas R, Piersma SR, Baglio SR, Verhage M, et al.
The Journal of cell biology (2018) : . 111 202 WB, ICC; KD verified; tested species: mouse
Oxidized phagosomal NOX2 complex is replenished from lysosomes.
Dingjan I, Linders PT, van den Bekerom L, Baranov MV, Halder P, Ter Beest M, van den Bogaart G
Journal of cell science (2017) 1307: 1285-1298. 111 202 WB, ICC; KD verified; tested species: human
SNAP-25 gene family members differentially support secretory vesicle fusion.
Arora S, Saarloos I, Kooistra R, van de Bospoort R, Verhage M, Toonen RF
Journal of cell science (2017) 13011: 1877-1889. 111 202 ICC; tested species: mouse
Selected SNARE proteins are essential for the polarized membrane insertion of igf-1 receptor and the regulation of initial axonal outgrowth in neurons.
Grassi D, Plonka FB, Oksdath M, Guil AN, Sosa LJ, Quiroga S
Cell discovery (2015) 1: 15023. 111 202 WB, ICC
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 111 202 WB, ICC, IHC; tested species: mouse,rat
Temporal characteristics of vesicular fusion in astrocytes: examination of synaptobrevin 2-laden vesicles at single vesicle resolution.
Malarkey EB, Parpura V
The Journal of physiology (2011) 58917: 4271-300. 111 202 ICC; tested species: rat
Immunofluorescence microscopy of SNAP23 in human skeletal muscle reveals colocalization with plasma membrane, lipid droplets, and mitochondria.
Strauss JA, Shaw CS, Bradley H, Wilson OJ, Dorval T, Pilling J, Wagenmakers AJ
Physiological reports (2016) 41: . 111 202 IHC
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 111 202 WB, ICC, IHC; tested species: mouse,rat
Choroid plexus epithelial cells express the adhesion protein P-cadherin at cell-cell contacts and syntaxin-4 in the luminal membrane domain.
Christensen IB, Mogensen EN, Damkier HH, Praetorius J
American journal of physiology. Cell physiology (2018) 3145: C519-C533. 111 202 IHC-P; tested species: mouse
SNAP23 is selectively expressed in airway secretory cells and mediates baseline and stimulated mucin secretion.
Ren B, Azzegagh Z, Jaramillo AM, Zhu Y, Pardo-Saganta A, Bagirzadeh R, Flores JR, Han W, Tang YJ, Tu J, Alanis DM, et al.
Bioscience reports (2015) 353: . 111 202 IHC-P; tested species: mouse
WB
Background

SNAP 23 (synaptosome-associated protein of 23 kDa) is an ubiquitously expressed isoform and functional homologue of SNAP 25. It is resistant to cleavage by BoNT/A and E. The protein is part of the exocytotic fusion complex (v-SNARE) where it assembles with syntaxin 1 and synaptobrevin.
SNAP 23 is able to function in regulated exocytosis. Both isoforms may have their own specific binding partners and discrete, albeit mechanistically similar, functional roles within the cell.
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