Cat. No.: 105 143
Amount: 50 µg
Price:
$375.00
|
|
|
| Cat. No. 105 143 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to AA 40 to 151 from rat Synaptotagmin4 (UniProt Id: P50232) |
| Reactivity |
Reacts with: human (Q9H2B2), rat (P50232), mouse (P40749), hamster. Other species not tested yet. |
| Specificity | K.O. validated |
| Matching control protein/peptide | 105-4P |
| Remarks |
WB: Cat. no. 105 043 is recommended for this application. |
| Data sheet | 105_143.pdf |
|
|
Up to now at least 17 synaptotagmins have been identified. Synaptotagmin4 is composed of a vesicular, a transmembrane and two C2 domains. Only the C2B domain is able to bind calcium. In the C2A domain one of the calcium binding aspartates has been substituted for serine leading to a loss of its binding capabilities.
The localization of synaptotagmin4 is still under discussion. A localization to synaptic vesicles (SVs) has been postulated but more recent studies suggest that it is present in the Golgi compartment, in distal parts of neurites and on large dense core vesicles (LDCVs) of NGF differentiated PC12 cells.