|Cat. No. 104 303||50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.|
WB: 1 : 1000 (AP staining) gallery
IP: not tested yet
ICC: 1 : 100 up to 1 : 500 gallery
IHC-P/FFPE: not tested yet
|Immunogen||Recombinant protein corresponding to AA 1 to 75 from rat Endobrevin (UniProt Id: Q9WUF4)|
Reacts with: human (Q9BV40), rat (Q9WUF4), mouse (O70404).
Other species not tested yet.
|Specificity||Specific for endobrevin. K.O. PubMed: 25138214|
Endobrevin/VAMP8, a member of the SNARE family of proteins, is a relative of synaptobrevin that is involved in the fusion of early and late endosomes. Endobrevin is expressed in most mammalian cells but appears to be absent from neurons. The protein is predominantly localized to early and late endosomal membranes but is also found on other membranes and organelles involved in endocytic membrane traffic. In the fusion of late endosomes it forms SNARE complexes with syntaxin 7, syntaxin 8 and vti1b.