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Synaptoporin - 102 011

A synaptic vesicle membrane protein enriched in Mossy fibres
Monoclonal mouse purified IgG
Cat. No.: 102 011
Amount: 100 µg
Price: $415.00
Cat. No. 102 011 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 AP staining gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 1000 up to 1 : 2000 (see remarks) gallery  
IHC-P/FFPE: 1 : 1000 gallery  
Clone 44E3D12
Subtype IgG2b (κ light chain)
Immunogen Synthetic peptide corresponding to AA 250 to 263 from rat Synaptoporin (UniProt Id: P22831)
Epitop Epitop: AA 250 to 263 from rat Synaptoporin (UniProt Id: P22831)
Reactivity Reacts with: mouse (Q8BGN8), rat (P22831).
Other species not tested yet.
Specificity Specific for synaptoporin.
Matching control protein/peptide 102-1P

IHC: In addition to the expected strong mossy fibre staining, this antibody shows some weak unspecific staining of cell bodies in the cortex, striatum and cerebellum.

Data sheet 102_011.pdf
Cat. No.: 102 011
Quantity: 100 µg
Price: $415.00

Synaptoporin, also known as synaptophysin 2 and p38-2, is highly homologous to synaptophysin 1 but encoded by a different gene. Like synaptopysin 1, synaptoporin contains four transmembrane regions and a short cytoplasmic tail. Unlike synaptophysin 1, it is not glycosylated.
The distributions of synaptophysin 1 and synaptoporin are different. Synaptophysin 1 is more uniformly expressed whereas synaptoporin is particularly enriched in mossy fiber synapses in the hippocampus. It is thus an excellent marker for subsets of synapses.