Cat. No.: 101 011AbOR
Amount: 50 µg
Price:
$465.00
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| Cat. No. 101 011AbOR |
50 µg purified IgG, lyophilized, fluorescence-labeled with abberior STAR ORANGE.
abberior STAR® dyes have been especially developed for for Stimulated Emission Depletion (STED) microscopy which allows higher resolution imaging compared to confocal laser scanning microscopy. For many of the fluorescence labeled antibodies conjugated to abberior STAR® dyes established fluorescence detection systems can be used. This product or portions thereof is manufactured under license from abberior GmbH. Reconstitute immediately upon receipt! Avoid bright light when working with the antibody to minimize photo bleeching of the fluorescent dye. |
| Applications |
IP: N/A ICC: 1 : 300 (see remarks) gallery IHC: not tested yet IHC-P: not tested yet ELISA: N/A |
| Label | abberior STAR ORANGE |
| Clone | 7.2 |
| Subtype | IgG1 (λ light chain) |
| Immunogen | Full-length recombinant rat Synaptophysin1 (UniProt Id: P07825) |
| Epitop |
AA 219 to 307 from rat Synaptophysin1 (UniProt Id: P07825) corresponding to the cytoplasmic tail. |
| Reactivity |
Reacts with: human (P08247), rat (P07825), mouse (Q62277), mammals. Weaker signal: zebrafish, other vertebrates. Other species not tested yet. |
| Specificity | K.O. validated |
| Remarks |
ICC: This antibody conjugate is especially suitable for high resolution STED microscopy. |
| Data sheet | 101_011abor.pdf |
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Synaptophysin1, also referred to as p38-1, is a membrane glycoprotein of synaptic vesicles that is ubiquitously expressed in all neurons and in many endocrine cells. It is currently the most widely used marker for nerve terminals and probably the best marker for the pathologist in differentiating neuroendocrine tumors.
Synaptophysin1 has four transmembrane domains with both N- and C-terminus facing the cytoplasm. It binds to synaptobrevin1 and synaptobrevin2 in detergent extracts but its function has not been elucidated completely. It forms a complex with dynamin at high Ca2+ concentration suggesting an involvement in synaptic vesicle endocytosis. As typical for synaptic vesicle proteins, synaptophysin1 represents a small protein family with two additonal members, synaptoporin (synaptophysin2) and panthophysin. Like synaptophysin1, synaptoporin is widely expressed in neurons and colocalizes with synaptophysin1 on synaptic vesicles whereas panthophysin is expressed in all tissues.