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Synaptophysin 1 - 101 004

Major synaptic vesicle membrane protein; neuroendocrine tumor marker
Polyclonal Guinea pig antiserum
Cat. No.: 101 004
Amount: 100 µl
Price: $375.00
Cat. No. 101 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 1000 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 200 gallery  
Immunogen Synthetic peptide corresponding to AA 301 to 313 from human Synaptophysin1 (UniProt Id: P08247)
Reactivity Reacts with: human (P08247), rat (P07825), mouse (Q62277), hamster, cow, chicken, frog.
Other species not tested yet.
Specificity Specific for synaptophysin 1, no cross-reactivity to other synaptophysins.
Matching control protein/peptide 101-0P
Data sheet 101_004.pdf

References for Synaptophysin 1 - 101 004

Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.
Emperador-Melero J, de Nola G, Kaeser PS
eLife (2021) 10: . 101 004 WB, ICC; tested species: mouse
Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction.
Comer AL, Jinadasa T, Sriram B, Phadke RA, Kretsge LN, Nguyen TPH, Antognetti G, Gilbert JP, Lee J, Newmark ER, Hausmann FS, et al.
PLoS biology (2020) 181: e3000604. 101 004 WB; tested species: mouse
AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation.
Peter S, Urbanus BHA, Klaassen RV, Wu B, Boele HJ, Azizi S, Slotman JA, Houtsmuller AB, Schonewille M, Hoebeek FE, Spijker S, et al.
Cell reports (2020) 312: 107515. 101 004 WB; tested species: mouse
Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons.
Vevea JD, Chapman ER
eLife (2020) 9: . 101 004 WB, ICC; tested species: mouse
Rho-kinase inhibition by fasudil modulates pre-synaptic vesicle dynamics.
Saal KA, Warth Pérez Arias C, Roser AE, Christoph Koch J, Bähr M, Rizzoli SO, Lingor P
Journal of neurochemistry (2020) : . 101 004 WB; tested species: rat
cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis.
Ojelade SA, Lee TV, Giagtzoglou N, Yu L, Ugur B, Li Y, Duraine L, Zuo Z, Petyuk V, De Jager PL, Bennett DA, et al.
Cell reports (2019) 287: 1799-1813.e5. 101 004 WB; tested species: mouse
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, et al.
Neuron (2019) 1014: 673-689.e11. 101 004 WB, ICC; tested species: mouse
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, et al.
Neuron (2018) : . 101 004 WB; tested species: mouse
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 101 004 WB, ICC
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 101 004 WB, ICC, IHC
Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.
Emperador-Melero J, de Nola G, Kaeser PS
eLife (2021) 10: . 101 004 WB, ICC; tested species: mouse
Presynaptic activity and protein turnover are correlated at the single-synapse level.
Jähne S, Mikulasch F, Heuer HGH, Truckenbrodt S, Agüi-Gonzalez P, Grewe K, Vogts A, Rizzoli SO, Priesemann V
Cell reports (2021) 3411: 108841. 101 004 ICC; tested species: rat
The Coding and Small Non-coding Hippocampal Synaptic RNAome.
Epple R, Krüger D, Berulava T, Brehm G, Islam R, Köster S, Fischer A
Molecular neurobiology (2021) : . 101 004 ICC; tested species: mouse
Neuron-Glia Interactions in Tuberous Sclerosis Complex Affect the Synaptic Balance in 2D and Organoid Cultures.
Dooves S, van Velthoven AJH, Suciati LG, Heine VM
Cells (2021) 101: . 101 004 ICC; tested species: human
Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells.
Chen M, Maimaitili M, Habekost M, Gill KP, Mermet-Joret N, Nabavi S, Febbraro F, Denham M
Stem cell research (2020) 48: 101945. 101 004 ICC; tested species: human
A Munc18-1 mutant mimicking phosphorylation by Down Syndrome-related kinase Dyrk1a supports normal synaptic transmission and promotes recovery after intense activity.
Classen J, Saarloos I, Meijer M, Sullivan PF, Verhage M
Scientific reports (2020) 101: 3181. 101 004 ICC; tested species: mouse
Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder.
Bradberry MM, Courtney NA, Dominguez MJ, Lofquist SM, Knox AT, Sutton RB, Chapman ER
Neuron (2020) : . 101 004 ICC; tested species: mouse
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Nyitrai H, Wang SSH, Kaeser PS
Cell reports (2020) 3110: 107712. 101 004 ICC; tested species: mouse
Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons.
Vevea JD, Chapman ER
eLife (2020) 9: . 101 004 WB, ICC; tested species: mouse
Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons.
Hoogstraaten RI, van Keimpema L, Toonen RF, Verhage M
Scientific reports (2020) 101: 10913. 101 004 ICC; tested species: mouse
A comparative analysis of the mobility of 45 proteins in the synaptic bouton.
Reshetniak S, Ußling JE, Perego E, Rammner B, Schikorski T, Fornasiero EF, Truckenbrodt S, Köster S, Rizzoli SO
The EMBO journal (2020) : e104596. 101 004 ICC; tested species: rat
Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression.
Rexach JE, Polioudakis D, Yin A, Swarup V, Chang TS, Nguyen T, Sarkar A, Chen L, Huang J, Lin LC, Seeley W, et al.
Cell reports (2020) 337: 108398. 101 004 ICC; tested species: mouse
The Interaction of Munc18-1 Helix 11 and 12 with the Central Region of the VAMP2 SNARE Motif Is Essential for SNARE Templating and Synaptic Transmission.
André T, Classen J, Brenner P, Betts M, Dörr B, Kreye S, Zuidinga B, Meijer M, Russell RB, Verhage M, Söllner TH, et al.
eNeuro (2020) : . 101 004 ICC; tested species: mouse
Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain.
Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL
eLife (2020) 9: . 101 004 ICC; tested species: mouse
Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.
Held RG, Liu C, Ma K, Ramsey AM, Tarr TB, De Nola G, Wang SSH, Wang J, van den Maagdenberg AMJM, Schneider T, Sun J, et al.
Neuron (2020) 1074: 667-683.e9. 101 004 ICC; tested species: mouse
CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles.
Ivanova D, Imig C, Camacho M, Reinhold A, Guhathakurta D, Montenegro-Venegas C, Cousin MA, Gundelfinger ED, Rosenmund C, Cooper B, Fejtova A, et al.
Cell reports (2020) 307: 2444-2459.e7. 101 004 ICC; tested species: mouse
A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol.
Gerdes C, Waal N, Offner T, Fornasiero EF, Wender N, Verbarg H, Manzini I, Trenkwalder C, Mollenhauer B, Strohäker T, Zweckstetter M, et al.
Nature communications (2020) 111: 2729. 101 004 ICC; tested species: rat
MicroRNAs and Ascl1 facilitate direct conversion of porcine fibroblasts into induced neurons.
Habekost M, Jørgensen AL, Qvist P, Denham M
Stem cell research (2020) 48: 101984. 101 004 ICC; tested species: pig
SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering.
Brouwer M, Farzana F, Koopmans F, Chen N, Brunner JW, Oldani S, Li KW, van Weering JR, Smit AB, Toonen RF, Verhage M, et al.
The EMBO journal (2019) : e101289. 101 004 ICC; tested species: mouse
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, et al.
Neuron (2019) 1014: 673-689.e11. 101 004 WB, ICC; tested species: mouse
Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.
King CR, A A Quadros AR, Chazeau A, Saarloos I, van der Graaf AJ, Verhage M, Toonen RF
Scientific reports (2019) 91: 8179. 101 004 ICC; tested species: mouse
NPC1 enables cholesterol mobilization during long-term potentiation that can be restored in Niemann-Pick disease type C by CYP46A1 activation.
Mitroi DN, Pereyra-Gómez G, Soto-Huelin B, Senovilla F, Kobayashi T, Esteban JA, Ledesma MD
EMBO reports (2019) : e48143. 101 004 ICC; tested species: mouse
Fluoxetine Suppresses Glutamate- and GABA-Mediated Neurotransmission by Altering SNARE Complex.
Lazarevic V, Mantas I, Flais I, Svenningsson P
International journal of molecular sciences (2019) 2017: . 101 004 ICC; tested species: rat
Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin.
Courtney NA, Bao H, Briguglio JS, Chapman ER
Nature communications (2019) 101: 4076. 101 004 ICC; tested species: mouse
High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity.
Verschuuren M, Verstraelen P, García-Díaz Barriga G, Cilissen I, Coninx E, Verslegers M, Larsen PH, Nuydens R, De Vos WH
Acta neuropathologica communications (2019) 71: 6. 101 004 ICC; tested species: mouse
Critical role for piccolo in synaptic vesicle retrieval.
Ackermann F, Schink KO, Bruns C, Izsvák Z, Hamra FK, Rosenmund C, Garner CC
eLife (2019) 8: . 101 004 ICC; tested species: rat
Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice.
Rojek KO, Krzemień J, Doleżyczek H, Boguszewski PM, Kaczmarek L, Konopka W, Rylski M, Jaworski J, Holmgren L, Prószyński TJ
PLoS biology (2019) 175: e3000253. 101 004 ICC, IHC; tested species: mouse,rat
A practical guide to optimization in X10 expansion microscopy.
Truckenbrodt S, Sommer C, Rizzoli SO, Danzl JG
Nature protocols (2019) : . 101 004 ICC; tested species: rat
A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development.
Zhang X, McGrath PS, Salomone J, Rahal M, McCauley HA, Schweitzer J, Kovall R, Gebelein B, Wells JM
Developmental cell (2019) : . 101 004 ICC; tested species: human
Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.
Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO
The EMBO journal (2018) : . 101 004 ICC; tested species: rat
Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B.
Dominguez N, van Weering JRT, Borges R, Toonen RFG, Verhage M
Journal of neurochemistry (2018) 1443: 241-254. 101 004 ICC; tested species: mouse
Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi.
Emperador-Melero J, Huson V, van Weering J, Bollmann C, Fischer von Mollard G, Toonen RF, Verhage M
Nature communications (2018) 91: 3421. 101 004 ICC; tested species: mouse
Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines.
Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang P, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, et al.
Neuron (2018) 975: 1110-1125.e14. 101 004 ICC; tested species: mouse
The Transmembrane Domain of Synaptobrevin Influences Neurotransmitter Flux Through Synaptic Fusion Pores.
Chiang CW, Chang CW, Jackson MB
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 101 004 ICC; tested species: mouse
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 101 004 WB, ICC
BDNF/trkB Induction of Calcium Transients through Cav2.2 Calcium Channels in Motoneurons Corresponds to F-actin Assembly and Growth Cone Formation on β2-Chain Laminin (221).
Dombert B, Balk S, Lüningschrör P, Moradi M, Sivadasan R, Saal-Bauernschubert L, Jablonka S
Frontiers in molecular neuroscience (2017) 10: 346. 101 004 ICC; tested species: mouse
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 101 004 WB, ICC, IHC
In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells.
Krishtal J, Bragina O, Metsla K, Palumaa P, Tõugu V
PloS one (2017) 1210: e0186636. 101 004 ICC; tested species: human
Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.
Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Strømgaard K
Nature chemical biology (2017) 132: 153-160. 101 004 ICC; tested species: mouse
SNAP-25 gene family members differentially support secretory vesicle fusion.
Arora S, Saarloos I, Kooistra R, van de Bospoort R, Verhage M, Toonen RF
Journal of cell science (2017) 13011: 1877-1889. 101 004 ICC; tested species: mouse
Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction.
Grochowska KM, Yuanxiang P, Bär J, Raman R, Brugal G, Sahu G, Schweizer M, Bikbaev A, Schilling S, Demuth HU, Kreutz MR, et al.
EMBO reports (2017) 186: 962-981. 101 004 ICC; tested species: rat
Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion.
Chang CW, Chiang CW, Gaffaney JD, Chapman ER, Jackson MB
The Journal of biological chemistry (2016) 2916: 2848-57. 101 004 ICC; KO verified
Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking.
Wang SSH, Held RG, Wong MY, Liu C, Karakhanyan A, Kaeser PS
Neuron (2016) 914: 777-791. 101 004 ICC
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.
Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM, et al.
Frontiers in cellular neuroscience (2015) 9: 496. 101 004 ICC; tested species: rat
Structural elements that underlie Doc2β function during asynchronous synaptic transmission.
Xue R, Gaffaney JD, Chapman ER
Proceedings of the National Academy of Sciences of the United States of America (2015) 11231: E4316-25. 101 004 ICC; tested species: mouse
Plexin-B3 suppresses excitatory and promotes inhibitory synapse formation in rat hippocampal neurons.
Laht P, Tammaru E, Otsus M, Rohtla J, Tiismus L, Veske A
Experimental cell research (2015) 3352: 269-78. 101 004 ICC
Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.
Ivanova D, Dirks A, Montenegro-Venegas C, Schöne C, Altrock WD, Marini C, Frischknecht R, Schanze D, Zenker M, Gundelfinger ED, Fejtova A, et al.
The EMBO journal (2015) 348: 1056-77. 101 004 ICC
Correlated optical and isotopic nanoscopy.
Saka SK, Vogts A, Kröhnert K, Hillion F, Rizzoli SO, Wessels JT
Nature communications (2014) 5: 3664. 101 004 ICC; tested species: rat
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 101 004 ICC; tested species: rat
Regulation of presynaptic anchoring of the scaffold protein Bassoon by phosphorylation-dependent interaction with 14-3-3 adaptor proteins.
Schröder MS, Stellmacher A, Romorini S, Marini C, Montenegro-Venegas C, Altrock WD, Gundelfinger ED, Fejtova A
PloS one (2013) 83: e58814. 101 004 ICC; tested species: mouse
Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons.
Kroken AR, Karalewitz AP, Fu Z, Kim JJ, Barbieri JT
The Journal of biological chemistry (2011) 28630: 26828-37. 101 004 ICC; tested species: rat
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200. 101 004 ICC
Fragile X astrocytes induce developmental delays in dendrite maturation and synaptic protein expression.
Jacobs S, Nathwani M, Doering LC
BMC neuroscience (2010) 11: 132. 101 004 ICC
Nanobodies reveal an extra-synaptic population of SNAP-25 and Syntaxin 1A in hippocampal neurons.
Maidorn M, Olichon A, Rizzoli SO, Opazo F
mAbs () 112: 305-321. 101 004 ICC; tested species: mouse
Microglial recruitment and mechanisms involved in the disruption of afferent synaptic terminals on spinal cord motor neurons after acute peripheral nerve injury.
Salvany S, Casanovas A, Piedrafita L, Tarabal O, Hernández S, Calderó J, Esquerda JE
Glia (2021) : . 101 004 IHC; tested species: mouse
Rapid Aging in the Perforant Path Projections to the Rodent Dentate Gyrus.
Amani M, Lauterborn JC, Le AA, Cox BM, Wang W, Quintanilla J, Cox CD, Gall CM, Lynch G
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 101 004 IHC; tested species: rat
Aberrant axo-axonic synaptic reorganization in the phosphorylated L1-CAM/calcium channel subunit alpha2 delta-1-containing central terminals of injured c-fibers in the spinal cord of a neuropathic pain model.
Yamanaka H, Okubo M, Kobayashi K, Noguchi K
eNeuro (2021) : . 101 004 IHC; tested species: rat
Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models.
Marques RF, Engler JB, Küchler K, Jones RA, Lingner T, Salinas G, Gillingwater TH, Friese MA, Duncan KE
Human molecular genetics (2020) 2916: 2647-2661. 101 004 IHC; tested species: mouse
Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas.
Florkowska A, Meszka I, Zawada M, Legutko D, Proszynski TJ, Janczyk-Ilach K, Streminska W, Ciemerych MA, Grabowska I
Stem cell research & therapy (2020) 111: 238. 101 004 IHC; tested species: mouse
Different dendritic domains of the GnRH neuron underlie the pulse and surge modes of GnRH secretion in female mice.
Wang L, Guo W, Shen X, Yeo S, Long H, Wang Z, Lyu Q, Herbison AE, Kuang Y
eLife (2020) 9: . 101 004 IHC; tested species: mouse
The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice.
Gerbino V, Kaunga E, Ye J, Canzio D, O'Keeffe S, Rudnick ND, Guarnieri P, Lutz CM, Maniatis T
Neuron (2020) : . 101 004 IHC; tested species: mouse
Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy.
Simon CM, Van Alstyne M, Lotti F, Bianchetti E, Tisdale S, Watterson DM, Mentis GZ, Pellizzoni L
Cell reports (2019) 2912: 3885-3901.e5. 101 004 IHC; tested species: mouse
Microglia Regulate Pruning of Specialized Synapses in the Auditory Brainstem.
Milinkeviciute G, Henningfield CM, Muniak MA, Chokr SM, Green KN, Cramer KS
Frontiers in neural circuits (2019) 13: 55. 101 004 IHC; tested species: mouse
Disturbed prefrontal cortex activity in the absence of schizophrenia-like behavioral dysfunction in Arc/Arg3.1 deficient mice.
Gao X, Grendel J, Muhia M, Castro-Gomez S, Süsens U, Isbrandt D, Kneussel M, Kuhl D, Ohana O
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 101 004 IHC; tested species: mouse
Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging.
Beckman D, Ott S, Donis-Cox K, Janssen WG, Bliss-Moreau E, Rudebeck PH, Baxter MG, Morrison JH
Proceedings of the National Academy of Sciences of the United States of America (2019) : . 101 004 IHC; tested species: monkey
The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA.
Vukojicic A, Delestrée N, Fletcher EV, Pagiazitis JG, Sankaranarayanan S, Yednock TA, Barres BA, Mentis GZ
Cell reports (2019) 2910: 3087-3100.e7. 101 004 IHC; tested species: mouse
Arterial Baroreceptors Sense Blood Pressure through Decorated Aortic Claws.
Min S, Chang RB, Prescott SL, Beeler B, Joshi NR, Strochlic DE, Liberles SD
Cell reports (2019) 298: 2192-2201.e3. 101 004 IHC; tested species: mouse
Transfer of the Experimental Autoimmune Glaucoma Model from Rats to Mice-New Options to Study Glaucoma Disease.
Reinehr S, Reinhard J, Wiemann S, Hesse K, Voss C, Gandej M, Dick HB, Faissner A, Joachim SC
International journal of molecular sciences (2019) 2010: . 101 004 IHC; tested species: mouse
TIP60/KAT5 is required for neuronal viability in hippocampal CA1.
Urban I, Kerimoglu C, Sakib MS, Wang H, Benito E, Thaller C, Zhou X, Yan J, Fischer A, Eichele G
Scientific reports (2019) 91: 16173. 101 004 IHC; tested species: mouse
FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis.
Picchiarelli G, Demestre M, Zuko A, Been M, Higelin J, Dieterlé S, Goy MA, Mallik M, Sellier C, Scekic-Zahirovic J, Zhang L, et al.
Nature neuroscience (2019) : . 101 004 IHC; tested species: mouse
An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity.
Schwenk J, Boudkkazi S, Kocylowski MK, Brechet A, Zolles G, Bus T, Costa K, Kollewe A, Jordan J, Bank J, Bildl W, et al.
Neuron (2019) : . 101 004 IHC; tested species: human,mouse
Early pre- and postsynaptic decrease in glutamatergic and cholinergic signaling after spinalization is not modified when stimulating proprioceptive input to the ankle extensor α-motoneurons: Anatomical and neurochemical study.
Grycz K, Głowacka A, Ji B, Czarkowska-Bauch J, Gajewska-Woźniak O, Skup M
PloS one (2019) 149: e0222849. 101 004 IHC; tested species: rat
Therapeutic effects of combined cell transplantation and locomotor training in rats with brain injury.
Shimogawa T, Sakaguchi H, Kikuchi T, Tsuchimochi R, Sano N, Torikoshi S, Ito A, Aoyama T, Iihara K, Takahashi J
NPJ Regenerative medicine (2019) 4: 13. 101 004 IHC; tested species: mouse
Noncoding deletions reveal a gene that is critical for intestinal function.
Oz-Levi D, Olender T, Bar-Joseph I, Zhu Y, Marek-Yagel D, Barozzi I, Osterwalder M, Alkelai A, Ruzzo EK, Han Y, Vos ESM, et al.
Nature (2019) : . 101 004 IHC; tested species: mouse
NETO1 Regulates Postsynaptic Kainate Receptors in CA3 Interneurons During Circuit Maturation.
Orav E, Dowavic I, Huupponen J, Taira T, Lauri SE
Molecular neurobiology (2019) : . 101 004 IHC; tested species: mouse
Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice.
Rojek KO, Krzemień J, Doleżyczek H, Boguszewski PM, Kaczmarek L, Konopka W, Rylski M, Jaworski J, Holmgren L, Prószyński TJ
PLoS biology (2019) 175: e3000253. 101 004 ICC, IHC; tested species: mouse,rat
Quantifying the Heterogeneous Distribution of a Synaptic Protein in the Mouse Brain Using Immunofluorescence.
Wallrafen R, Dresbach T, Viotti JS
Journal of visualized experiments : JoVE (2019) 143: . 101 004 IHC; tested species: mouse
Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.
Merlini M, Rafalski VA, Rios Coronado PE, Gill TM, Ellisman M, Muthukumar G, Subramanian KS, Ryu JK, Syme CA, Davalos D, Seeley WW, et al.
Neuron (2019) : . 101 004 IHC; tested species: mouse
T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses.
Garber C, Soung A, Vollmer LL, Kanmogne M, Last A, Brown J, Klein RS
Nature neuroscience (2019) : . 101 004 IHC; tested species: mouse
The Presynaptic Protein Mover Is Differentially Expressed Across Brain Areas and Synapse Types.
Wallrafen R, Dresbach T
Frontiers in neuroanatomy (2018) 12: 58. 101 004 IHC; tested species: mouse
Hypoxia activates a neuropeptidergic pathway from the paraventricular nucleus of the hypothalamus to the nucleus tractus solitarii.
Ruyle BC, Klutho PJ, Baines CP, Heesch CM, Hasser EM
American journal of physiology. Regulatory, integrative and comparative physiology (2018) : . 101 004 IHC; tested species: rat
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites.
Bloss EB, Cembrowski MS, Karsh B, Colonell J, Fetter RD, Spruston N
Nature neuroscience (2018) 213: 353-363. 101 004 IHC; tested species: mouse
Macrophage depletion ameliorates peripheral neuropathy in aging mice.
Yuan X, Klein D, Kerscher S, West BL, Weis J, Katona I, Martini R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 101 004 IHC; tested species: mouse
Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1.
Garber C, Vasek MJ, Vollmer LL, Sun T, Jiang X, Klein RS
Nature immunology (2018) 192: 151-161. 101 004 IHC; tested species: mouse
APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission.
Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller UC, Kins S, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3721: 5345-5365. 101 004 IHC; tested species: mouse
Long-term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice.
Stroobants S, Damme M, Van der Jeugd A, Vermaercke B, Andersson C, Fogh J, Saftig P, Blanz J, D'Hooge R
Neurobiology of disease (2017) 106: 255-268. 101 004 IHC; tested species: mouse
Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS.
Rudnick ND, Griffey CJ, Guarnieri P, Gerbino V, Wang X, Piersaint JA, Tapia JC, Rich MM, Maniatis T
Proceedings of the National Academy of Sciences of the United States of America (2017) 11439: E8294-E8303. 101 004 IHC; tested species: mouse
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 101 004 WB, ICC, IHC
Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot-Marie-Tooth disease in mice.
Klein D, Patzkó Á, Schreiber D, van Hauwermeiren A, Baier M, Groh J, West BL, Martini R
Brain : a journal of neurology (2015) 138Pt 11: 3193-205. 101 004 IHC; tested species: mouse
GABAergic signaling in the pulmonary neuroepithelial body microenvironment: functional imaging in GAD67-GFP mice.
Schnorbusch K, Lembrechts R, Pintelon I, Timmermans JP, Brouns I, Adriaensen D
Histochemistry and cell biology (2013) 1405: 549-66. 101 004 IHC
5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii.
Austgen JR, Dantzler HA, Barger BK, Kline DD
Journal of neurophysiology (2012) 1088: 2292-305. 101 004 IHC; tested species: rat
Cat. No.: 101 004
Quantity: 100 µl
Price: $375.00
Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.
Emperador-Melero J, de Nola G, Kaeser PS
eLife (2021) 10: . 101 004 WB, ICC; tested species: mouse
Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction.
Comer AL, Jinadasa T, Sriram B, Phadke RA, Kretsge LN, Nguyen TPH, Antognetti G, Gilbert JP, Lee J, Newmark ER, Hausmann FS, et al.
PLoS biology (2020) 181: e3000604. 101 004 WB; tested species: mouse
AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation.
Peter S, Urbanus BHA, Klaassen RV, Wu B, Boele HJ, Azizi S, Slotman JA, Houtsmuller AB, Schonewille M, Hoebeek FE, Spijker S, et al.
Cell reports (2020) 312: 107515. 101 004 WB; tested species: mouse
Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons.
Vevea JD, Chapman ER
eLife (2020) 9: . 101 004 WB, ICC; tested species: mouse
Rho-kinase inhibition by fasudil modulates pre-synaptic vesicle dynamics.
Saal KA, Warth Pérez Arias C, Roser AE, Christoph Koch J, Bähr M, Rizzoli SO, Lingor P
Journal of neurochemistry (2020) : . 101 004 WB; tested species: rat
cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis.
Ojelade SA, Lee TV, Giagtzoglou N, Yu L, Ugur B, Li Y, Duraine L, Zuo Z, Petyuk V, De Jager PL, Bennett DA, et al.
Cell reports (2019) 287: 1799-1813.e5. 101 004 WB; tested species: mouse
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, et al.
Neuron (2019) 1014: 673-689.e11. 101 004 WB, ICC; tested species: mouse
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, et al.
Neuron (2018) : . 101 004 WB; tested species: mouse
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 101 004 WB, ICC
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 101 004 WB, ICC, IHC
Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.
Emperador-Melero J, de Nola G, Kaeser PS
eLife (2021) 10: . 101 004 WB, ICC; tested species: mouse
Presynaptic activity and protein turnover are correlated at the single-synapse level.
Jähne S, Mikulasch F, Heuer HGH, Truckenbrodt S, Agüi-Gonzalez P, Grewe K, Vogts A, Rizzoli SO, Priesemann V
Cell reports (2021) 3411: 108841. 101 004 ICC; tested species: rat
The Coding and Small Non-coding Hippocampal Synaptic RNAome.
Epple R, Krüger D, Berulava T, Brehm G, Islam R, Köster S, Fischer A
Molecular neurobiology (2021) : . 101 004 ICC; tested species: mouse
Neuron-Glia Interactions in Tuberous Sclerosis Complex Affect the Synaptic Balance in 2D and Organoid Cultures.
Dooves S, van Velthoven AJH, Suciati LG, Heine VM
Cells (2021) 101: . 101 004 ICC; tested species: human
Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells.
Chen M, Maimaitili M, Habekost M, Gill KP, Mermet-Joret N, Nabavi S, Febbraro F, Denham M
Stem cell research (2020) 48: 101945. 101 004 ICC; tested species: human
A Munc18-1 mutant mimicking phosphorylation by Down Syndrome-related kinase Dyrk1a supports normal synaptic transmission and promotes recovery after intense activity.
Classen J, Saarloos I, Meijer M, Sullivan PF, Verhage M
Scientific reports (2020) 101: 3181. 101 004 ICC; tested species: mouse
Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder.
Bradberry MM, Courtney NA, Dominguez MJ, Lofquist SM, Knox AT, Sutton RB, Chapman ER
Neuron (2020) : . 101 004 ICC; tested species: mouse
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Nyitrai H, Wang SSH, Kaeser PS
Cell reports (2020) 3110: 107712. 101 004 ICC; tested species: mouse
Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons.
Vevea JD, Chapman ER
eLife (2020) 9: . 101 004 WB, ICC; tested species: mouse
Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons.
Hoogstraaten RI, van Keimpema L, Toonen RF, Verhage M
Scientific reports (2020) 101: 10913. 101 004 ICC; tested species: mouse
A comparative analysis of the mobility of 45 proteins in the synaptic bouton.
Reshetniak S, Ußling JE, Perego E, Rammner B, Schikorski T, Fornasiero EF, Truckenbrodt S, Köster S, Rizzoli SO
The EMBO journal (2020) : e104596. 101 004 ICC; tested species: rat
Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression.
Rexach JE, Polioudakis D, Yin A, Swarup V, Chang TS, Nguyen T, Sarkar A, Chen L, Huang J, Lin LC, Seeley W, et al.
Cell reports (2020) 337: 108398. 101 004 ICC; tested species: mouse
The Interaction of Munc18-1 Helix 11 and 12 with the Central Region of the VAMP2 SNARE Motif Is Essential for SNARE Templating and Synaptic Transmission.
André T, Classen J, Brenner P, Betts M, Dörr B, Kreye S, Zuidinga B, Meijer M, Russell RB, Verhage M, Söllner TH, et al.
eNeuro (2020) : . 101 004 ICC; tested species: mouse
Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain.
Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL
eLife (2020) 9: . 101 004 ICC; tested species: mouse
Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.
Held RG, Liu C, Ma K, Ramsey AM, Tarr TB, De Nola G, Wang SSH, Wang J, van den Maagdenberg AMJM, Schneider T, Sun J, et al.
Neuron (2020) 1074: 667-683.e9. 101 004 ICC; tested species: mouse
CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles.
Ivanova D, Imig C, Camacho M, Reinhold A, Guhathakurta D, Montenegro-Venegas C, Cousin MA, Gundelfinger ED, Rosenmund C, Cooper B, Fejtova A, et al.
Cell reports (2020) 307: 2444-2459.e7. 101 004 ICC; tested species: mouse
A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol.
Gerdes C, Waal N, Offner T, Fornasiero EF, Wender N, Verbarg H, Manzini I, Trenkwalder C, Mollenhauer B, Strohäker T, Zweckstetter M, et al.
Nature communications (2020) 111: 2729. 101 004 ICC; tested species: rat
MicroRNAs and Ascl1 facilitate direct conversion of porcine fibroblasts into induced neurons.
Habekost M, Jørgensen AL, Qvist P, Denham M
Stem cell research (2020) 48: 101984. 101 004 ICC; tested species: pig
SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering.
Brouwer M, Farzana F, Koopmans F, Chen N, Brunner JW, Oldani S, Li KW, van Weering JR, Smit AB, Toonen RF, Verhage M, et al.
The EMBO journal (2019) : e101289. 101 004 ICC; tested species: mouse
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, et al.
Neuron (2019) 1014: 673-689.e11. 101 004 WB, ICC; tested species: mouse
Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.
King CR, A A Quadros AR, Chazeau A, Saarloos I, van der Graaf AJ, Verhage M, Toonen RF
Scientific reports (2019) 91: 8179. 101 004 ICC; tested species: mouse
NPC1 enables cholesterol mobilization during long-term potentiation that can be restored in Niemann-Pick disease type C by CYP46A1 activation.
Mitroi DN, Pereyra-Gómez G, Soto-Huelin B, Senovilla F, Kobayashi T, Esteban JA, Ledesma MD
EMBO reports (2019) : e48143. 101 004 ICC; tested species: mouse
Fluoxetine Suppresses Glutamate- and GABA-Mediated Neurotransmission by Altering SNARE Complex.
Lazarevic V, Mantas I, Flais I, Svenningsson P
International journal of molecular sciences (2019) 2017: . 101 004 ICC; tested species: rat
Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin.
Courtney NA, Bao H, Briguglio JS, Chapman ER
Nature communications (2019) 101: 4076. 101 004 ICC; tested species: mouse
High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity.
Verschuuren M, Verstraelen P, García-Díaz Barriga G, Cilissen I, Coninx E, Verslegers M, Larsen PH, Nuydens R, De Vos WH
Acta neuropathologica communications (2019) 71: 6. 101 004 ICC; tested species: mouse
Critical role for piccolo in synaptic vesicle retrieval.
Ackermann F, Schink KO, Bruns C, Izsvák Z, Hamra FK, Rosenmund C, Garner CC
eLife (2019) 8: . 101 004 ICC; tested species: rat
Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice.
Rojek KO, Krzemień J, Doleżyczek H, Boguszewski PM, Kaczmarek L, Konopka W, Rylski M, Jaworski J, Holmgren L, Prószyński TJ
PLoS biology (2019) 175: e3000253. 101 004 ICC, IHC; tested species: mouse,rat
A practical guide to optimization in X10 expansion microscopy.
Truckenbrodt S, Sommer C, Rizzoli SO, Danzl JG
Nature protocols (2019) : . 101 004 ICC; tested species: rat
A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development.
Zhang X, McGrath PS, Salomone J, Rahal M, McCauley HA, Schweitzer J, Kovall R, Gebelein B, Wells JM
Developmental cell (2019) : . 101 004 ICC; tested species: human
Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.
Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO
The EMBO journal (2018) : . 101 004 ICC; tested species: rat
Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B.
Dominguez N, van Weering JRT, Borges R, Toonen RFG, Verhage M
Journal of neurochemistry (2018) 1443: 241-254. 101 004 ICC; tested species: mouse
Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi.
Emperador-Melero J, Huson V, van Weering J, Bollmann C, Fischer von Mollard G, Toonen RF, Verhage M
Nature communications (2018) 91: 3421. 101 004 ICC; tested species: mouse
Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines.
Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang P, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, et al.
Neuron (2018) 975: 1110-1125.e14. 101 004 ICC; tested species: mouse
The Transmembrane Domain of Synaptobrevin Influences Neurotransmitter Flux Through Synaptic Fusion Pores.
Chiang CW, Chang CW, Jackson MB
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 101 004 ICC; tested species: mouse
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 101 004 WB, ICC
BDNF/trkB Induction of Calcium Transients through Cav2.2 Calcium Channels in Motoneurons Corresponds to F-actin Assembly and Growth Cone Formation on β2-Chain Laminin (221).
Dombert B, Balk S, Lüningschrör P, Moradi M, Sivadasan R, Saal-Bauernschubert L, Jablonka S
Frontiers in molecular neuroscience (2017) 10: 346. 101 004 ICC; tested species: mouse
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 101 004 WB, ICC, IHC
In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells.
Krishtal J, Bragina O, Metsla K, Palumaa P, Tõugu V
PloS one (2017) 1210: e0186636. 101 004 ICC; tested species: human
Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.
Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Strømgaard K
Nature chemical biology (2017) 132: 153-160. 101 004 ICC; tested species: mouse
SNAP-25 gene family members differentially support secretory vesicle fusion.
Arora S, Saarloos I, Kooistra R, van de Bospoort R, Verhage M, Toonen RF
Journal of cell science (2017) 13011: 1877-1889. 101 004 ICC; tested species: mouse
Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction.
Grochowska KM, Yuanxiang P, Bär J, Raman R, Brugal G, Sahu G, Schweizer M, Bikbaev A, Schilling S, Demuth HU, Kreutz MR, et al.
EMBO reports (2017) 186: 962-981. 101 004 ICC; tested species: rat
Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion.
Chang CW, Chiang CW, Gaffaney JD, Chapman ER, Jackson MB
The Journal of biological chemistry (2016) 2916: 2848-57. 101 004 ICC; KO verified
Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking.
Wang SSH, Held RG, Wong MY, Liu C, Karakhanyan A, Kaeser PS
Neuron (2016) 914: 777-791. 101 004 ICC
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.
Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM, et al.
Frontiers in cellular neuroscience (2015) 9: 496. 101 004 ICC; tested species: rat
Structural elements that underlie Doc2β function during asynchronous synaptic transmission.
Xue R, Gaffaney JD, Chapman ER
Proceedings of the National Academy of Sciences of the United States of America (2015) 11231: E4316-25. 101 004 ICC; tested species: mouse
Plexin-B3 suppresses excitatory and promotes inhibitory synapse formation in rat hippocampal neurons.
Laht P, Tammaru E, Otsus M, Rohtla J, Tiismus L, Veske A
Experimental cell research (2015) 3352: 269-78. 101 004 ICC
Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.
Ivanova D, Dirks A, Montenegro-Venegas C, Schöne C, Altrock WD, Marini C, Frischknecht R, Schanze D, Zenker M, Gundelfinger ED, Fejtova A, et al.
The EMBO journal (2015) 348: 1056-77. 101 004 ICC
Correlated optical and isotopic nanoscopy.
Saka SK, Vogts A, Kröhnert K, Hillion F, Rizzoli SO, Wessels JT
Nature communications (2014) 5: 3664. 101 004 ICC; tested species: rat
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 101 004 ICC; tested species: rat
Regulation of presynaptic anchoring of the scaffold protein Bassoon by phosphorylation-dependent interaction with 14-3-3 adaptor proteins.
Schröder MS, Stellmacher A, Romorini S, Marini C, Montenegro-Venegas C, Altrock WD, Gundelfinger ED, Fejtova A
PloS one (2013) 83: e58814. 101 004 ICC; tested species: mouse
Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons.
Kroken AR, Karalewitz AP, Fu Z, Kim JJ, Barbieri JT
The Journal of biological chemistry (2011) 28630: 26828-37. 101 004 ICC; tested species: rat
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200. 101 004 ICC
Fragile X astrocytes induce developmental delays in dendrite maturation and synaptic protein expression.
Jacobs S, Nathwani M, Doering LC
BMC neuroscience (2010) 11: 132. 101 004 ICC
Nanobodies reveal an extra-synaptic population of SNAP-25 and Syntaxin 1A in hippocampal neurons.
Maidorn M, Olichon A, Rizzoli SO, Opazo F
mAbs () 112: 305-321. 101 004 ICC; tested species: mouse
Microglial recruitment and mechanisms involved in the disruption of afferent synaptic terminals on spinal cord motor neurons after acute peripheral nerve injury.
Salvany S, Casanovas A, Piedrafita L, Tarabal O, Hernández S, Calderó J, Esquerda JE
Glia (2021) : . 101 004 IHC; tested species: mouse
Rapid Aging in the Perforant Path Projections to the Rodent Dentate Gyrus.
Amani M, Lauterborn JC, Le AA, Cox BM, Wang W, Quintanilla J, Cox CD, Gall CM, Lynch G
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 101 004 IHC; tested species: rat
Aberrant axo-axonic synaptic reorganization in the phosphorylated L1-CAM/calcium channel subunit alpha2 delta-1-containing central terminals of injured c-fibers in the spinal cord of a neuropathic pain model.
Yamanaka H, Okubo M, Kobayashi K, Noguchi K
eNeuro (2021) : . 101 004 IHC; tested species: rat
Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models.
Marques RF, Engler JB, Küchler K, Jones RA, Lingner T, Salinas G, Gillingwater TH, Friese MA, Duncan KE
Human molecular genetics (2020) 2916: 2647-2661. 101 004 IHC; tested species: mouse
Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas.
Florkowska A, Meszka I, Zawada M, Legutko D, Proszynski TJ, Janczyk-Ilach K, Streminska W, Ciemerych MA, Grabowska I
Stem cell research & therapy (2020) 111: 238. 101 004 IHC; tested species: mouse
Different dendritic domains of the GnRH neuron underlie the pulse and surge modes of GnRH secretion in female mice.
Wang L, Guo W, Shen X, Yeo S, Long H, Wang Z, Lyu Q, Herbison AE, Kuang Y
eLife (2020) 9: . 101 004 IHC; tested species: mouse
The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice.
Gerbino V, Kaunga E, Ye J, Canzio D, O'Keeffe S, Rudnick ND, Guarnieri P, Lutz CM, Maniatis T
Neuron (2020) : . 101 004 IHC; tested species: mouse
Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy.
Simon CM, Van Alstyne M, Lotti F, Bianchetti E, Tisdale S, Watterson DM, Mentis GZ, Pellizzoni L
Cell reports (2019) 2912: 3885-3901.e5. 101 004 IHC; tested species: mouse
Microglia Regulate Pruning of Specialized Synapses in the Auditory Brainstem.
Milinkeviciute G, Henningfield CM, Muniak MA, Chokr SM, Green KN, Cramer KS
Frontiers in neural circuits (2019) 13: 55. 101 004 IHC; tested species: mouse
Disturbed prefrontal cortex activity in the absence of schizophrenia-like behavioral dysfunction in Arc/Arg3.1 deficient mice.
Gao X, Grendel J, Muhia M, Castro-Gomez S, Süsens U, Isbrandt D, Kneussel M, Kuhl D, Ohana O
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 101 004 IHC; tested species: mouse
Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging.
Beckman D, Ott S, Donis-Cox K, Janssen WG, Bliss-Moreau E, Rudebeck PH, Baxter MG, Morrison JH
Proceedings of the National Academy of Sciences of the United States of America (2019) : . 101 004 IHC; tested species: monkey
The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA.
Vukojicic A, Delestrée N, Fletcher EV, Pagiazitis JG, Sankaranarayanan S, Yednock TA, Barres BA, Mentis GZ
Cell reports (2019) 2910: 3087-3100.e7. 101 004 IHC; tested species: mouse
Arterial Baroreceptors Sense Blood Pressure through Decorated Aortic Claws.
Min S, Chang RB, Prescott SL, Beeler B, Joshi NR, Strochlic DE, Liberles SD
Cell reports (2019) 298: 2192-2201.e3. 101 004 IHC; tested species: mouse
Transfer of the Experimental Autoimmune Glaucoma Model from Rats to Mice-New Options to Study Glaucoma Disease.
Reinehr S, Reinhard J, Wiemann S, Hesse K, Voss C, Gandej M, Dick HB, Faissner A, Joachim SC
International journal of molecular sciences (2019) 2010: . 101 004 IHC; tested species: mouse
TIP60/KAT5 is required for neuronal viability in hippocampal CA1.
Urban I, Kerimoglu C, Sakib MS, Wang H, Benito E, Thaller C, Zhou X, Yan J, Fischer A, Eichele G
Scientific reports (2019) 91: 16173. 101 004 IHC; tested species: mouse
FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis.
Picchiarelli G, Demestre M, Zuko A, Been M, Higelin J, Dieterlé S, Goy MA, Mallik M, Sellier C, Scekic-Zahirovic J, Zhang L, et al.
Nature neuroscience (2019) : . 101 004 IHC; tested species: mouse
An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity.
Schwenk J, Boudkkazi S, Kocylowski MK, Brechet A, Zolles G, Bus T, Costa K, Kollewe A, Jordan J, Bank J, Bildl W, et al.
Neuron (2019) : . 101 004 IHC; tested species: human,mouse
Early pre- and postsynaptic decrease in glutamatergic and cholinergic signaling after spinalization is not modified when stimulating proprioceptive input to the ankle extensor α-motoneurons: Anatomical and neurochemical study.
Grycz K, Głowacka A, Ji B, Czarkowska-Bauch J, Gajewska-Woźniak O, Skup M
PloS one (2019) 149: e0222849. 101 004 IHC; tested species: rat
Therapeutic effects of combined cell transplantation and locomotor training in rats with brain injury.
Shimogawa T, Sakaguchi H, Kikuchi T, Tsuchimochi R, Sano N, Torikoshi S, Ito A, Aoyama T, Iihara K, Takahashi J
NPJ Regenerative medicine (2019) 4: 13. 101 004 IHC; tested species: mouse
Noncoding deletions reveal a gene that is critical for intestinal function.
Oz-Levi D, Olender T, Bar-Joseph I, Zhu Y, Marek-Yagel D, Barozzi I, Osterwalder M, Alkelai A, Ruzzo EK, Han Y, Vos ESM, et al.
Nature (2019) : . 101 004 IHC; tested species: mouse
NETO1 Regulates Postsynaptic Kainate Receptors in CA3 Interneurons During Circuit Maturation.
Orav E, Dowavic I, Huupponen J, Taira T, Lauri SE
Molecular neurobiology (2019) : . 101 004 IHC; tested species: mouse
Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice.
Rojek KO, Krzemień J, Doleżyczek H, Boguszewski PM, Kaczmarek L, Konopka W, Rylski M, Jaworski J, Holmgren L, Prószyński TJ
PLoS biology (2019) 175: e3000253. 101 004 ICC, IHC; tested species: mouse,rat
Quantifying the Heterogeneous Distribution of a Synaptic Protein in the Mouse Brain Using Immunofluorescence.
Wallrafen R, Dresbach T, Viotti JS
Journal of visualized experiments : JoVE (2019) 143: . 101 004 IHC; tested species: mouse
Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.
Merlini M, Rafalski VA, Rios Coronado PE, Gill TM, Ellisman M, Muthukumar G, Subramanian KS, Ryu JK, Syme CA, Davalos D, Seeley WW, et al.
Neuron (2019) : . 101 004 IHC; tested species: mouse
T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses.
Garber C, Soung A, Vollmer LL, Kanmogne M, Last A, Brown J, Klein RS
Nature neuroscience (2019) : . 101 004 IHC; tested species: mouse
The Presynaptic Protein Mover Is Differentially Expressed Across Brain Areas and Synapse Types.
Wallrafen R, Dresbach T
Frontiers in neuroanatomy (2018) 12: 58. 101 004 IHC; tested species: mouse
Hypoxia activates a neuropeptidergic pathway from the paraventricular nucleus of the hypothalamus to the nucleus tractus solitarii.
Ruyle BC, Klutho PJ, Baines CP, Heesch CM, Hasser EM
American journal of physiology. Regulatory, integrative and comparative physiology (2018) : . 101 004 IHC; tested species: rat
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites.
Bloss EB, Cembrowski MS, Karsh B, Colonell J, Fetter RD, Spruston N
Nature neuroscience (2018) 213: 353-363. 101 004 IHC; tested species: mouse
Macrophage depletion ameliorates peripheral neuropathy in aging mice.
Yuan X, Klein D, Kerscher S, West BL, Weis J, Katona I, Martini R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 101 004 IHC; tested species: mouse
Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1.
Garber C, Vasek MJ, Vollmer LL, Sun T, Jiang X, Klein RS
Nature immunology (2018) 192: 151-161. 101 004 IHC; tested species: mouse
APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission.
Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller UC, Kins S, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3721: 5345-5365. 101 004 IHC; tested species: mouse
Long-term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice.
Stroobants S, Damme M, Van der Jeugd A, Vermaercke B, Andersson C, Fogh J, Saftig P, Blanz J, D'Hooge R
Neurobiology of disease (2017) 106: 255-268. 101 004 IHC; tested species: mouse
Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS.
Rudnick ND, Griffey CJ, Guarnieri P, Gerbino V, Wang X, Piersaint JA, Tapia JC, Rich MM, Maniatis T
Proceedings of the National Academy of Sciences of the United States of America (2017) 11439: E8294-E8303. 101 004 IHC; tested species: mouse
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 101 004 WB, ICC, IHC
Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot-Marie-Tooth disease in mice.
Klein D, Patzkó Á, Schreiber D, van Hauwermeiren A, Baier M, Groh J, West BL, Martini R
Brain : a journal of neurology (2015) 138Pt 11: 3193-205. 101 004 IHC; tested species: mouse
GABAergic signaling in the pulmonary neuroepithelial body microenvironment: functional imaging in GAD67-GFP mice.
Schnorbusch K, Lembrechts R, Pintelon I, Timmermans JP, Brouns I, Adriaensen D
Histochemistry and cell biology (2013) 1405: 549-66. 101 004 IHC
5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii.
Austgen JR, Dantzler HA, Barger BK, Kline DD
Journal of neurophysiology (2012) 1088: 2292-305. 101 004 IHC; tested species: rat
Background

Synaptophysin 1, also referred to as p38-1, is a membrane glycoprotein of synaptic vesicles that is ubiquitously expressed in all neurons and in many endocrine cells. It is currently the most widely used marker for nerve terminals and probably the best marker for the pathologist in differentiating neuroendocrine tumors.
Synaptophysin 1 has four transmembrane domains with both N- and C-terminus facing the cytoplasm. It binds to synaptobrevin 1 and synaptobrevin 2 in detergent extracts but its function has not been elucidated completely. It forms a complex with dynamin at high Ca2+ concentration suggesting an involvement in synaptic vesicle endocytosis. As typical for synaptic vesicle proteins, synaptophysin 1 represents a small protein family with two additonal members, synaptoporin (synaptophysin 2) and panthophysin. Like synaptophysin 1, synaptoporin is widely expressed in neurons and colocalizes with synaptophysin 1 on synaptic vesicles whereas panthophysin is expressed in all tissues.