Home|||||||Technical Support|

IBA1 - 234 004

Marker for macrophages and microglia
Polyclonal Guinea pig antiserum
Cat. No.: 234 004
Amount: 100 µl
Price: $375.00
Cat. No. 234 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 500 (see remarks) gallery  
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 134 to 147 from rat IBA1 (UniProt Id: P55009)
Reactivity Reacts with: human (P55008), rat (P55009), mouse (O70200), sheep, ape.
No signal: zebrafish.
Other species not tested yet.
Specificity Specific for IBA 1. K.O.
Matching control protein/peptide 234-0P
Remarks

IHC: Does not work with Acetone fixed tissue.

Data sheet 234_004.pdf

References for IBA1 - 234 004

Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF.
Buffolo F, Petrosino V, Albini M, Moschetta M, Carlini F, Floss T, Kerlero de Rosbo N, Cesca F, Rocchi A, Uccelli A, Benfenati F, et al.
Cell death & disease (2021) 122: 180. 234 004 ICC; tested species: mouse
Aging and sex: Impact on microglia phagocytosis.
Yanguas-Casás N, Crespo-Castrillo A, Arevalo MA, Garcia-Segura LM
Aging cell (2020) : e13182. 234 004 ICC; tested species: mouse
Construction of a 3D brain extracellular matrix model to study the interaction between microglia and T cells in co-culture.
Frühauf M, Zeitschel U, Höfling C, Ullm F, Rabiger FV, Alber G, Pompe T, Müller U, Roßner S
The European journal of neuroscience (2020) : . 234 004 ICC; tested species: mouse
Kidins220/ARMS controls astrocyte calcium signaling and neuron-astrocyte communication.
Jaudon F, Chiacchiaretta M, Albini M, Ferroni S, Benfenati F, Cesca F
Cell death and differentiation (2019) : . 234 004 ICC; tested species: mouse
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition.
Colombo AV, Sadler RK, Llovera G, Singh V, Roth S, Heindl S, Sebastian Monasor L, Verhoeven A, Peters F, Parhizkar S, Kamp F, et al.
eLife (2021) 10: . 234 004 IHC; tested species: mouse
Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction.
Comer AL, Jinadasa T, Sriram B, Phadke RA, Kretsge LN, Nguyen TPH, Antognetti G, Gilbert JP, Lee J, Newmark ER, Hausmann FS, et al.
PLoS biology (2020) 181: e3000604. 234 004 IHC; tested species: mouse
A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation.
Böhm S, Splith V, Riedmayr LM, Rötzer RD, Gasparoni G, Nordström KJV, Wagner JE, Hinrichsmeyer KS, Walter J, Wahl-Schott C, Fenske S, et al.
Science advances (2020) 634: eaba5614. 234 004 IHC; tested species: mouse
A mouse model of complete-crush transection spinal cord injury made by two operations.
Li C, Zhu X, Lee CM, Wu Z, Cheng L
Annals of translational medicine (2020) 85: 210. 234 004 IHC; tested species: mouse
Examination of ex-vivo viability of human adipose tissue slice culture.
Schopow N, Kallendrusch S, Gong S, Rapp F, Körfer J, Gericke M, Spindler N, Josten C, Langer S, Bechmann I
PloS one (2020) 155: e0233152. 234 004 IHC; tested species: human
Amyloidosis is associated with thicker myelin and increased oligodendrogenesis in the adult mouse brain.
Ferreira S, Pitman KA, Wang S, Summers BS, Bye N, Young KM, Cullen CL
Journal of neuroscience research (2020) : . 234 004 IHC; tested species: mouse
Progressive Long-term Spatial Memory Loss following Repeat Concussive and Subconcussive Brain Injury in Mice, Associated with Dorsal Hippocampal Neuron Loss, Microglial Phenotype Shift, and Vascular Abnormalities.
Honig MG, Dorian CC, Worthen JD, Micetich AC, Mulder IA, Sanchez KB, Pierce WF, Del Mar NA, Reiner A
The European journal of neuroscience (2020) : . 234 004 IHC; tested species: mouse
Sarm1 loss reduces axonal damage and improves cognitive outcome after repetitive mild closed head injury.
Maynard ME, Redell JB, Zhao J, Hood KN, Vita SM, Kobori N, Dash PK
Experimental neurology (2020) 327: 113207. 234 004 IHC; tested species: mouse
Novel Hexb-based tools for studying microglia in the CNS.
Masuda T, Amann L, Sankowski R, Staszewski O, Lenz M, D Errico P, Snaidero N, Costa Jordão MJ, Böttcher C, Kierdorf K, Jung S, et al.
Nature immunology (2020) 217: 802-815. 234 004 IHC; tested species: mouse
Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier.
Hauptmann J, Johann L, Marini F, Kitic M, Colombo E, Mufazalov IA, Krueger M, Karram K, Moos S, Wanke F, Kurschus FC, et al.
Acta neuropathologica (2020) : . 234 004 IHC; tested species: mouse
Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions.
OʼShea TM, Wollenberg AL, Kim JH, Ao Y, Deming TJ, Sofroniew MV
Nature communications (2020) 111: 6203. 234 004 IHC; tested species: mouse
Neuronal brain-derived neurotrophic factor manipulates microglial dynamics.
Onodera J, Nagata H, Nakashima A, Ikegaya Y, Koyama R
Glia (2020) : . 234 004 IHC; tested species: mouse
Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model.
Boeck M, Thien A, Wolf J, Hagemeyer N, Laich Y, Yusuf D, Backofen R, Zhang P, Boneva S, Stahl A, Hilgendorf I, et al.
Glia (2020) : . 234 004 IHC; tested species: mouse
P-glycoprotein Expression Is Upregulated in a Pre-Clinical Model of Traumatic Brain Injury.
Vita SM, Redell JB, Maynard ME, Zhao J, Grill RJ, Dash PK, Grayson BE
Neurotrauma reports (2020) 11: 207-217. 234 004 IHC; tested species: mouse
Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Is a Negative Regulator of Oligodendrocyte Progenitor Cell Differentiation in the Adult Mouse Brain.
Auderset L, Pitman KA, Cullen CL, Pepper RE, Taylor BV, Foa L, Young KM
Frontiers in cell and developmental biology (2020) 8: 564351. 234 004 IHC; tested species: mouse
Langat virus infection affects hippocampal neuron morphology and function in mice without disease signs.
Cornelius ADA, Hosseini S, Schreier S, Fritzsch D, Weichert L, Michaelsen-Preusse K, Fendt M, Kröger A
Journal of neuroinflammation (2020) 171: 278. 234 004 IHC; tested species: mouse
C9orf72 suppresses systemic and neural inflammation induced by gut bacteria.
Burberry A, Wells MF, Limone F, Couto A, Smith KS, Keaney J, Gillet G, van Gastel N, Wang JY, Pietilainen O, Qian M, et al.
Nature (2020) 5827810: 89-94. 234 004 IHC; tested species: mouse
Quantification of Huntington's Disease Related Markers in the R6/2 Mouse Model.
Etxeberria-Rekalde E, Alzola-Aldamizetxebarria S, Flunkert S, Hable I, Daurer M, Neddens J, Hutter-Paier B
Frontiers in molecular neuroscience (2020) 13: 617229. 234 004 IHC; tested species: mouse
Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.
Kovács RÁ, Vadászi H, Bulyáki É, Török G, Tóth V, Mátyás D, Kun J, Hunyadi-Gulyás É, Fedor FZ, Csincsi Á, Medzihradszky K, et al.
Frontiers in immunology (2020) 11: 599771. 234 004 IHC; tested species: mouse
Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.
Ndoja A, Reja R, Lee SH, Webster JD, Ngu H, Rose CM, Kirkpatrick DS, Modrusan Z, Chen YJ, Dugger DL, Gandham V, et al.
Cell (2020) 1825: 1156-1169.e12. 234 004 IHC; tested species: mouse
Oligodendrogenesis increases in hippocampal grey and white matter prior to locomotor or memory impairment in an adult mouse model of tauopathy.
Ferreira S, Pitman KA, Summers BS, Wang S, Young KM, Cullen CL
The European journal of neuroscience (2020) : . 234 004 IHC; tested species: mouse
Single-cell transcriptomic analysis of Alzheimer's disease.
Mathys H, Davila-Velderrain J, Peng Z, Gao F, Mohammadi S, Young JZ, Menon M, He L, Abdurrob F, Jiang X, Martorell AJ, et al.
Nature (2019) 5707761: 332-337. 234 004 IHC; tested species: human
Inhibition of Bruton's Tyrosine Kinase Modulates Microglial Phagocytosis: Therapeutic Implications for Alzheimer's Disease.
Keaney J, Gasser J, Gillet G, Scholz D, Kadiu I
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (2019) : . 234 004 IHC; tested species: mouse
Expression of Developmentally Important Axon Guidance Cues in the Adult Optic Chiasm.
Conceição R, Evans RS, Pearson CS, Hänzi B, Osborne A, Deshpande SS, Martin KR, Barber AC
Investigative ophthalmology & visual science (2019) 6014: 4727-4739. 234 004 IHC; tested species: mouse
Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity.
Yagensky O, Kohansal-Nodehi M, Gunaseelan S, Rabe T, Zafar S, Zerr I, Härtig W, Urlaub H, Chua JJ
eLife (2019) 8: . 234 004 IHC; tested species: mouse
Neurostatin and other O-acetylated gangliosides show anti-neuroinflammatory activity involving the NFκB pathway.
Yanguas-Casás N, Ojalvo-Sanz AC, Martínez-Vázquez A, Goneau MF, Gilbert M, Nieto-Sampedro M, Romero-Ramírez L
Toxicology and applied pharmacology (2019) : 114627. 234 004 IHC; tested species: mouse
Neuroinflammatory Changes in Relation to Cerebrospinal Fluid Viral Load in Simian Immunodeficiency Virus Encephalitis.
Hammoud DA, Sinharay S, Shah S, Schreiber-Stainthorp W, Maric D, Muthusamy S, Lee DE, Lee CA, Basuli F, Reid WC, Wakim P, et al.
mBio (2019) 103: . 234 004 IHC; tested species: monkey
Galectin-3 promotes Aβ oligomerization and Aβ toxicity in a mouse model of Alzheimer's disease.
Tao CC, Cheng KM, Ma YL, Hsu WL, Chen YC, Fuh JL, Lee WJ, Chao CC, Lee EHY
Cell death and differentiation (2019) : . 234 004 IHC; tested species: mouse
Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway.
Qin C, Liu Q, Hu ZW, Zhou LQ, Shang K, Bosco DB, Wu LJ, Tian DS, Wang W
Theranostics (2018) 819: 5434-5451. 234 004 IHC; tested species: mouse
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, et al.
Neuron (2018) : . 234 004 IHC; tested species: mouse
Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia.
Hüttenrauch M, Ogorek I, Klafki H, Otto M, Stadelmann C, Weggen S, Wiltfang J, Wirths O
Acta neuropathologica communications (2018) 61: 108. 234 004 IHC; tested species: mouse
A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target.
Srivastava PK, Eyll JV, Godard P, Mazzuferi M, Delahaye-Duriez A, Steenwinckel JV, Gressens P, Danis B, Vandenplas C, Foerch P, Leclercq K, et al.
Nature communications (2018) 91: 3561. 234 004 IHC; tested species: mouse
Long-lasting pathological consequences of overexpression-induced α-synuclein spreading in the rat brain.
Rusconi R, Ulusoy A, Aboutalebi H, Di Monte DA
Aging cell (2018) 172: . 234 004 IHC; tested species: rat
Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep.
Härtig W, Mages B, Aleithe S, Nitzsche B, Altmann S, Barthel H, Krueger M, Michalski D
Frontiers in integrative neuroscience (2017) 11: 15. 234 004 IHC; tested species: mouse,rat,sheep
Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction.
Grochowska KM, Yuanxiang P, Bär J, Raman R, Brugal G, Sahu G, Schweizer M, Bikbaev A, Schilling S, Demuth HU, Kreutz MR, et al.
EMBO reports (2017) 186: 962-981. 234 004 IHC; tested species: rat
Neuroprotection and Blood-Brain Barrier Restoration by Salubrinal After a Cortical Stab Injury.
Barreda-Manso MA, Yanguas-Casás N, Nieto-Sampedro M, Romero-Ramírez L
Journal of cellular physiology (2017) 2326: 1501-1510. 234 004 IHC; tested species: mouse
Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid.
Schläger C, Körner H, Krueger M, Vidoli S, Haberl M, Mielke D, Brylla E, Issekutz T, Cabañas C, Nelson PJ, Ziemssen T, et al.
Nature (2016) 5307590: 349-53. 234 004 IHC
Low Density Lipoprotein-Receptor Related Protein 1 Is Differentially Expressed by Neuronal and Glial Populations in the Developing and Mature Mouse Central Nervous System.
Auderset L, Cullen CL, Young KM
PloS one (2016) 116: e0155878. 234 004 IHC
The schizophrenia risk gene product miR-137 alters presynaptic plasticity.
Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH, et al.
Nature neuroscience (2015) 187: 1008-16. 234 004 IHC; tested species: mouse
Cellular distribution of the NMDA-receptor activated synapto-nuclear messenger Jacob in the rat brain.
Mikhaylova M, Karpova A, Bär J, Bethge P, YuanXiang P, Chen Y, Zuschratter W, Behnisch T, Kreutz MR
Brain structure & function (2014) 2193: 843-60. 234 004 IHC
Treatment of rats with spinal cord injury using human bone marrow-derived stromal cells prepared by negative selection.
Romero-Ramírez L, Wu S, de Munter J, Wolters EC, Kramer BW, Mey J
Journal of biomedical science (2020) 271: 35. 234 004 IHC-P; tested species: rat
The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck SE, Zampar S, Dimitrov M, Lehmann S, Lepka K, Berndt C, et al.
Acta neuropathologica (2018) : . 234 004 IHC-P; tested species: mouse
Cat. No.: 234 004
Quantity: 100 µl
Price: $375.00
Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF.
Buffolo F, Petrosino V, Albini M, Moschetta M, Carlini F, Floss T, Kerlero de Rosbo N, Cesca F, Rocchi A, Uccelli A, Benfenati F, et al.
Cell death & disease (2021) 122: 180. 234 004 ICC; tested species: mouse
Aging and sex: Impact on microglia phagocytosis.
Yanguas-Casás N, Crespo-Castrillo A, Arevalo MA, Garcia-Segura LM
Aging cell (2020) : e13182. 234 004 ICC; tested species: mouse
Construction of a 3D brain extracellular matrix model to study the interaction between microglia and T cells in co-culture.
Frühauf M, Zeitschel U, Höfling C, Ullm F, Rabiger FV, Alber G, Pompe T, Müller U, Roßner S
The European journal of neuroscience (2020) : . 234 004 ICC; tested species: mouse
Kidins220/ARMS controls astrocyte calcium signaling and neuron-astrocyte communication.
Jaudon F, Chiacchiaretta M, Albini M, Ferroni S, Benfenati F, Cesca F
Cell death and differentiation (2019) : . 234 004 ICC; tested species: mouse
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition.
Colombo AV, Sadler RK, Llovera G, Singh V, Roth S, Heindl S, Sebastian Monasor L, Verhoeven A, Peters F, Parhizkar S, Kamp F, et al.
eLife (2021) 10: . 234 004 IHC; tested species: mouse
Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction.
Comer AL, Jinadasa T, Sriram B, Phadke RA, Kretsge LN, Nguyen TPH, Antognetti G, Gilbert JP, Lee J, Newmark ER, Hausmann FS, et al.
PLoS biology (2020) 181: e3000604. 234 004 IHC; tested species: mouse
A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation.
Böhm S, Splith V, Riedmayr LM, Rötzer RD, Gasparoni G, Nordström KJV, Wagner JE, Hinrichsmeyer KS, Walter J, Wahl-Schott C, Fenske S, et al.
Science advances (2020) 634: eaba5614. 234 004 IHC; tested species: mouse
A mouse model of complete-crush transection spinal cord injury made by two operations.
Li C, Zhu X, Lee CM, Wu Z, Cheng L
Annals of translational medicine (2020) 85: 210. 234 004 IHC; tested species: mouse
Examination of ex-vivo viability of human adipose tissue slice culture.
Schopow N, Kallendrusch S, Gong S, Rapp F, Körfer J, Gericke M, Spindler N, Josten C, Langer S, Bechmann I
PloS one (2020) 155: e0233152. 234 004 IHC; tested species: human
Amyloidosis is associated with thicker myelin and increased oligodendrogenesis in the adult mouse brain.
Ferreira S, Pitman KA, Wang S, Summers BS, Bye N, Young KM, Cullen CL
Journal of neuroscience research (2020) : . 234 004 IHC; tested species: mouse
Progressive Long-term Spatial Memory Loss following Repeat Concussive and Subconcussive Brain Injury in Mice, Associated with Dorsal Hippocampal Neuron Loss, Microglial Phenotype Shift, and Vascular Abnormalities.
Honig MG, Dorian CC, Worthen JD, Micetich AC, Mulder IA, Sanchez KB, Pierce WF, Del Mar NA, Reiner A
The European journal of neuroscience (2020) : . 234 004 IHC; tested species: mouse
Sarm1 loss reduces axonal damage and improves cognitive outcome after repetitive mild closed head injury.
Maynard ME, Redell JB, Zhao J, Hood KN, Vita SM, Kobori N, Dash PK
Experimental neurology (2020) 327: 113207. 234 004 IHC; tested species: mouse
Novel Hexb-based tools for studying microglia in the CNS.
Masuda T, Amann L, Sankowski R, Staszewski O, Lenz M, D Errico P, Snaidero N, Costa Jordão MJ, Böttcher C, Kierdorf K, Jung S, et al.
Nature immunology (2020) 217: 802-815. 234 004 IHC; tested species: mouse
Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier.
Hauptmann J, Johann L, Marini F, Kitic M, Colombo E, Mufazalov IA, Krueger M, Karram K, Moos S, Wanke F, Kurschus FC, et al.
Acta neuropathologica (2020) : . 234 004 IHC; tested species: mouse
Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions.
OʼShea TM, Wollenberg AL, Kim JH, Ao Y, Deming TJ, Sofroniew MV
Nature communications (2020) 111: 6203. 234 004 IHC; tested species: mouse
Neuronal brain-derived neurotrophic factor manipulates microglial dynamics.
Onodera J, Nagata H, Nakashima A, Ikegaya Y, Koyama R
Glia (2020) : . 234 004 IHC; tested species: mouse
Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model.
Boeck M, Thien A, Wolf J, Hagemeyer N, Laich Y, Yusuf D, Backofen R, Zhang P, Boneva S, Stahl A, Hilgendorf I, et al.
Glia (2020) : . 234 004 IHC; tested species: mouse
P-glycoprotein Expression Is Upregulated in a Pre-Clinical Model of Traumatic Brain Injury.
Vita SM, Redell JB, Maynard ME, Zhao J, Grill RJ, Dash PK, Grayson BE
Neurotrauma reports (2020) 11: 207-217. 234 004 IHC; tested species: mouse
Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Is a Negative Regulator of Oligodendrocyte Progenitor Cell Differentiation in the Adult Mouse Brain.
Auderset L, Pitman KA, Cullen CL, Pepper RE, Taylor BV, Foa L, Young KM
Frontiers in cell and developmental biology (2020) 8: 564351. 234 004 IHC; tested species: mouse
Langat virus infection affects hippocampal neuron morphology and function in mice without disease signs.
Cornelius ADA, Hosseini S, Schreier S, Fritzsch D, Weichert L, Michaelsen-Preusse K, Fendt M, Kröger A
Journal of neuroinflammation (2020) 171: 278. 234 004 IHC; tested species: mouse
C9orf72 suppresses systemic and neural inflammation induced by gut bacteria.
Burberry A, Wells MF, Limone F, Couto A, Smith KS, Keaney J, Gillet G, van Gastel N, Wang JY, Pietilainen O, Qian M, et al.
Nature (2020) 5827810: 89-94. 234 004 IHC; tested species: mouse
Quantification of Huntington's Disease Related Markers in the R6/2 Mouse Model.
Etxeberria-Rekalde E, Alzola-Aldamizetxebarria S, Flunkert S, Hable I, Daurer M, Neddens J, Hutter-Paier B
Frontiers in molecular neuroscience (2020) 13: 617229. 234 004 IHC; tested species: mouse
Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.
Kovács RÁ, Vadászi H, Bulyáki É, Török G, Tóth V, Mátyás D, Kun J, Hunyadi-Gulyás É, Fedor FZ, Csincsi Á, Medzihradszky K, et al.
Frontiers in immunology (2020) 11: 599771. 234 004 IHC; tested species: mouse
Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.
Ndoja A, Reja R, Lee SH, Webster JD, Ngu H, Rose CM, Kirkpatrick DS, Modrusan Z, Chen YJ, Dugger DL, Gandham V, et al.
Cell (2020) 1825: 1156-1169.e12. 234 004 IHC; tested species: mouse
Oligodendrogenesis increases in hippocampal grey and white matter prior to locomotor or memory impairment in an adult mouse model of tauopathy.
Ferreira S, Pitman KA, Summers BS, Wang S, Young KM, Cullen CL
The European journal of neuroscience (2020) : . 234 004 IHC; tested species: mouse
Single-cell transcriptomic analysis of Alzheimer's disease.
Mathys H, Davila-Velderrain J, Peng Z, Gao F, Mohammadi S, Young JZ, Menon M, He L, Abdurrob F, Jiang X, Martorell AJ, et al.
Nature (2019) 5707761: 332-337. 234 004 IHC; tested species: human
Inhibition of Bruton's Tyrosine Kinase Modulates Microglial Phagocytosis: Therapeutic Implications for Alzheimer's Disease.
Keaney J, Gasser J, Gillet G, Scholz D, Kadiu I
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (2019) : . 234 004 IHC; tested species: mouse
Expression of Developmentally Important Axon Guidance Cues in the Adult Optic Chiasm.
Conceição R, Evans RS, Pearson CS, Hänzi B, Osborne A, Deshpande SS, Martin KR, Barber AC
Investigative ophthalmology & visual science (2019) 6014: 4727-4739. 234 004 IHC; tested species: mouse
Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity.
Yagensky O, Kohansal-Nodehi M, Gunaseelan S, Rabe T, Zafar S, Zerr I, Härtig W, Urlaub H, Chua JJ
eLife (2019) 8: . 234 004 IHC; tested species: mouse
Neurostatin and other O-acetylated gangliosides show anti-neuroinflammatory activity involving the NFκB pathway.
Yanguas-Casás N, Ojalvo-Sanz AC, Martínez-Vázquez A, Goneau MF, Gilbert M, Nieto-Sampedro M, Romero-Ramírez L
Toxicology and applied pharmacology (2019) : 114627. 234 004 IHC; tested species: mouse
Neuroinflammatory Changes in Relation to Cerebrospinal Fluid Viral Load in Simian Immunodeficiency Virus Encephalitis.
Hammoud DA, Sinharay S, Shah S, Schreiber-Stainthorp W, Maric D, Muthusamy S, Lee DE, Lee CA, Basuli F, Reid WC, Wakim P, et al.
mBio (2019) 103: . 234 004 IHC; tested species: monkey
Galectin-3 promotes Aβ oligomerization and Aβ toxicity in a mouse model of Alzheimer's disease.
Tao CC, Cheng KM, Ma YL, Hsu WL, Chen YC, Fuh JL, Lee WJ, Chao CC, Lee EHY
Cell death and differentiation (2019) : . 234 004 IHC; tested species: mouse
Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway.
Qin C, Liu Q, Hu ZW, Zhou LQ, Shang K, Bosco DB, Wu LJ, Tian DS, Wang W
Theranostics (2018) 819: 5434-5451. 234 004 IHC; tested species: mouse
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, et al.
Neuron (2018) : . 234 004 IHC; tested species: mouse
Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia.
Hüttenrauch M, Ogorek I, Klafki H, Otto M, Stadelmann C, Weggen S, Wiltfang J, Wirths O
Acta neuropathologica communications (2018) 61: 108. 234 004 IHC; tested species: mouse
A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target.
Srivastava PK, Eyll JV, Godard P, Mazzuferi M, Delahaye-Duriez A, Steenwinckel JV, Gressens P, Danis B, Vandenplas C, Foerch P, Leclercq K, et al.
Nature communications (2018) 91: 3561. 234 004 IHC; tested species: mouse
Long-lasting pathological consequences of overexpression-induced α-synuclein spreading in the rat brain.
Rusconi R, Ulusoy A, Aboutalebi H, Di Monte DA
Aging cell (2018) 172: . 234 004 IHC; tested species: rat
Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep.
Härtig W, Mages B, Aleithe S, Nitzsche B, Altmann S, Barthel H, Krueger M, Michalski D
Frontiers in integrative neuroscience (2017) 11: 15. 234 004 IHC; tested species: mouse,rat,sheep
Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction.
Grochowska KM, Yuanxiang P, Bär J, Raman R, Brugal G, Sahu G, Schweizer M, Bikbaev A, Schilling S, Demuth HU, Kreutz MR, et al.
EMBO reports (2017) 186: 962-981. 234 004 IHC; tested species: rat
Neuroprotection and Blood-Brain Barrier Restoration by Salubrinal After a Cortical Stab Injury.
Barreda-Manso MA, Yanguas-Casás N, Nieto-Sampedro M, Romero-Ramírez L
Journal of cellular physiology (2017) 2326: 1501-1510. 234 004 IHC; tested species: mouse
Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid.
Schläger C, Körner H, Krueger M, Vidoli S, Haberl M, Mielke D, Brylla E, Issekutz T, Cabañas C, Nelson PJ, Ziemssen T, et al.
Nature (2016) 5307590: 349-53. 234 004 IHC
Low Density Lipoprotein-Receptor Related Protein 1 Is Differentially Expressed by Neuronal and Glial Populations in the Developing and Mature Mouse Central Nervous System.
Auderset L, Cullen CL, Young KM
PloS one (2016) 116: e0155878. 234 004 IHC
The schizophrenia risk gene product miR-137 alters presynaptic plasticity.
Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH, et al.
Nature neuroscience (2015) 187: 1008-16. 234 004 IHC; tested species: mouse
Cellular distribution of the NMDA-receptor activated synapto-nuclear messenger Jacob in the rat brain.
Mikhaylova M, Karpova A, Bär J, Bethge P, YuanXiang P, Chen Y, Zuschratter W, Behnisch T, Kreutz MR
Brain structure & function (2014) 2193: 843-60. 234 004 IHC
Treatment of rats with spinal cord injury using human bone marrow-derived stromal cells prepared by negative selection.
Romero-Ramírez L, Wu S, de Munter J, Wolters EC, Kramer BW, Mey J
Journal of biomedical science (2020) 271: 35. 234 004 IHC-P; tested species: rat
The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck SE, Zampar S, Dimitrov M, Lehmann S, Lepka K, Berndt C, et al.
Acta neuropathologica (2018) : . 234 004 IHC-P; tested species: mouse
Background

Ionized calcium-binding adaptor molecule 1 (IBA1) or allograft inflammatory factor1 (AIF-1) is an EF hand calcium binding protein which is expressed by cells of the monocyte/macrophage lineage and by germ cells in the testis (1). In mice, IBA1/AIF-1 can be regarded a “pan-macrophage marker” because, except for alveolar macrophages, all subpopulations of macrophages express IBA1/AIF-1 (1). In human gliomas IBA1 defines a distinct subset of tumor-associated activated macrophages/microglial cells (2).
Microglia represent the resident macrophages in the nervous system and are the smallest of the glial cells with cell bodies of only 2-5 µm in diameter. In the CNS IBA1 upregulation is associated with neuroinflammatory response (3).