Cat. No.: 302 311
Amount: 100 µg
Price:
$415.00
|
|
|
| Cat. No. 302 311 |
100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | 356E3D10 |
| Subtype | IgG2a (κ light chain) |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of mouse β3-tubulin (UniProt Id: Q9ERD7) |
| Reactivity |
Reacts with: rat (Q4QRB4), mouse (Q9ERD7). Other species not tested yet. |
| Specificity | Specific for β3-tubulin. |
| Matching control protein/peptide | 302-3P |
| Data sheet | 302_311.pdf |
|
|
Microtubules are involved in a wide variety of cellular activities ranging from mitosis and transport events to cell movement and the maintainance of cell shape (1).
Tubulin itself is a globular protein which consists of two polypeptides, α-tubulin and β-tubulin. α- and β-tubulin dimers are assembled to 13 protofilaments that form a microtubule of 25 nm diameter (1).
Class III β-tubulin is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development (2).
It is widely used as a neuronal marker in normal and neoplastic tissues but has also been reported to be expressed in certain tumours of non-neuronal origin (3).